Control of haemonchosis in Malaysian goats with closantel
The therapeutic and prophylactic effects of closantel on natural infections with Haemonchus contortus were studied in goats in Peninsular Malaysia. Closantel was highly effective against H. contortus, either at a subcutaneous (s.c.) injection of 5.0 mg kg- ~ body weight (100%), or in an oral drench...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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Elsevier Science
1994
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| Online Access: | http://psasir.upm.edu.my/id/eprint/6245/ http://psasir.upm.edu.my/id/eprint/6245/1/Control%20of%20haemonchosis%20in%20Malaysian%20goats%20with%20closantel.pdf |
| _version_ | 1848840324711972864 |
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| author | Dorny, Pierre Vercruysse, Jozef Abu, Jalila Abdullah Sani, Rehana Symoens, Chantal |
| author_facet | Dorny, Pierre Vercruysse, Jozef Abu, Jalila Abdullah Sani, Rehana Symoens, Chantal |
| author_sort | Dorny, Pierre |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The therapeutic and prophylactic effects of closantel on natural infections with Haemonchus contortus were studied in goats in Peninsular Malaysia. Closantel was highly effective against H. contortus, either at a subcutaneous (s.c.) injection of 5.0 mg kg- ~ body weight (100%), or in an oral drench mixture with mebendazole at a dose of 10.0 mg kg-(99.2%), as indicated by faecal egg counts. H. contortus larvae were absent from faecal cultures for 5, 6 and 7 weeks following treatment with s.c. injections of closantel at doses of 2.5 mg kg- 1, 5.0 mg kg- ~ and 10.0 mg kg- 1 respectively, and for 6 weeks after treatment
with closantel at 10.0 mg kg -1, given orally. Through its sustained activity, closantel not only prevented reinfection with H. contortus but also caused a dramatic reduction in pasture contamination. The potential utility of closantel in the strategic control of haemonchosis
in goats, and as an alternative treatment for benzimidazoles and levamisole resistant H. contortus strains, is discussed. |
| first_indexed | 2025-11-15T07:25:32Z |
| format | Article |
| id | upm-6245 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:25:32Z |
| publishDate | 1994 |
| publisher | Elsevier Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-62452015-11-12T08:46:25Z http://psasir.upm.edu.my/id/eprint/6245/ Control of haemonchosis in Malaysian goats with closantel Dorny, Pierre Vercruysse, Jozef Abu, Jalila Abdullah Sani, Rehana Symoens, Chantal The therapeutic and prophylactic effects of closantel on natural infections with Haemonchus contortus were studied in goats in Peninsular Malaysia. Closantel was highly effective against H. contortus, either at a subcutaneous (s.c.) injection of 5.0 mg kg- ~ body weight (100%), or in an oral drench mixture with mebendazole at a dose of 10.0 mg kg-(99.2%), as indicated by faecal egg counts. H. contortus larvae were absent from faecal cultures for 5, 6 and 7 weeks following treatment with s.c. injections of closantel at doses of 2.5 mg kg- 1, 5.0 mg kg- ~ and 10.0 mg kg- 1 respectively, and for 6 weeks after treatment with closantel at 10.0 mg kg -1, given orally. Through its sustained activity, closantel not only prevented reinfection with H. contortus but also caused a dramatic reduction in pasture contamination. The potential utility of closantel in the strategic control of haemonchosis in goats, and as an alternative treatment for benzimidazoles and levamisole resistant H. contortus strains, is discussed. Elsevier Science 1994 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/6245/1/Control%20of%20haemonchosis%20in%20Malaysian%20goats%20with%20closantel.pdf Dorny, Pierre and Vercruysse, Jozef and Abu, Jalila and Abdullah Sani, Rehana and Symoens, Chantal (1994) Control of haemonchosis in Malaysian goats with closantel. Veterinary Parasitology, 53 (3-4). pp. 223-241. ISSN 0304-4017 http://dx.doi.org/10.1016/0304-4017(94)90186-4 10.1016/0304-4017(94)90186-4 English |
| spellingShingle | Dorny, Pierre Vercruysse, Jozef Abu, Jalila Abdullah Sani, Rehana Symoens, Chantal Control of haemonchosis in Malaysian goats with closantel |
| title | Control of haemonchosis in Malaysian goats with
closantel |
| title_full | Control of haemonchosis in Malaysian goats with
closantel |
| title_fullStr | Control of haemonchosis in Malaysian goats with
closantel |
| title_full_unstemmed | Control of haemonchosis in Malaysian goats with
closantel |
| title_short | Control of haemonchosis in Malaysian goats with
closantel |
| title_sort | control of haemonchosis in malaysian goats with
closantel |
| url | http://psasir.upm.edu.my/id/eprint/6245/ http://psasir.upm.edu.my/id/eprint/6245/ http://psasir.upm.edu.my/id/eprint/6245/ http://psasir.upm.edu.my/id/eprint/6245/1/Control%20of%20haemonchosis%20in%20Malaysian%20goats%20with%20closantel.pdf |