Mesenchymal stem cell-mediated T cell immunosuppression
Besides being a pool forstromal cells and connective tissues, the mesenchymal stem cells (MSCs) as well exert a potent immunosuppression against almost all types of immune cells, particularly T cells. Many in vitro and in vivo studies revealed that the reported regenerative property of MSCs is parti...
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| Format: | Article |
| Language: | English |
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Gavin Publishers
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/62394/ http://psasir.upm.edu.my/id/eprint/62394/1/Mesenchymal%20stem%20cell-mediated%20T%20cell%20immunosuppression.pdf |
| _version_ | 1848854620329213952 |
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| author | Al-Graittee, Satar Jabbar Rahi Lawal, Hamza Ramasamy, Rajesh |
| author_facet | Al-Graittee, Satar Jabbar Rahi Lawal, Hamza Ramasamy, Rajesh |
| author_sort | Al-Graittee, Satar Jabbar Rahi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Besides being a pool forstromal cells and connective tissues, the mesenchymal stem cells (MSCs) as well exert a potent immunosuppression against almost all types of immune cells, particularly T cells. Many in vitro and in vivo studies revealed that the reported regenerative property of MSCs is partially due to the immunosuppressive activity of MSCs where it creates an optimal microenvironment for the execution of reparative and restorative processes. To date, MSCs caninteract with nearly all cells of the immune system, in a convoluted mechanism with theabilityof inhibiting the activation, proliferation, and function of T cells. These characteristicsshowcaseMSCs’ candidature as anaturalimmunosuppressive agent in regenerative medicine, therapies for immune disorders and tissue engineering. In this review, the intricate mechanisms of MSC-mediated immunosuppression on Tcellswere briefly evaluated. The physical, paracrine and molecular interactions that being toolsfor delivering the immunosuppressionwere also highlighted. |
| first_indexed | 2025-11-15T11:12:46Z |
| format | Article |
| id | upm-62394 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:12:46Z |
| publishDate | 2017 |
| publisher | Gavin Publishers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-623942020-01-10T04:14:07Z http://psasir.upm.edu.my/id/eprint/62394/ Mesenchymal stem cell-mediated T cell immunosuppression Al-Graittee, Satar Jabbar Rahi Lawal, Hamza Ramasamy, Rajesh Besides being a pool forstromal cells and connective tissues, the mesenchymal stem cells (MSCs) as well exert a potent immunosuppression against almost all types of immune cells, particularly T cells. Many in vitro and in vivo studies revealed that the reported regenerative property of MSCs is partially due to the immunosuppressive activity of MSCs where it creates an optimal microenvironment for the execution of reparative and restorative processes. To date, MSCs caninteract with nearly all cells of the immune system, in a convoluted mechanism with theabilityof inhibiting the activation, proliferation, and function of T cells. These characteristicsshowcaseMSCs’ candidature as anaturalimmunosuppressive agent in regenerative medicine, therapies for immune disorders and tissue engineering. In this review, the intricate mechanisms of MSC-mediated immunosuppression on Tcellswere briefly evaluated. The physical, paracrine and molecular interactions that being toolsfor delivering the immunosuppressionwere also highlighted. Gavin Publishers 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62394/1/Mesenchymal%20stem%20cell-mediated%20T%20cell%20immunosuppression.pdf Al-Graittee, Satar Jabbar Rahi and Lawal, Hamza and Ramasamy, Rajesh (2017) Mesenchymal stem cell-mediated T cell immunosuppression. Stem Cell: Advanced Research and Therapy, 2017 (3). pp. 1-5. ISSN 2637-9589 https://gavinpublishers.com/articles/research-article/Stem-Cell-Advanced-Research-and-Therapy/mesenchymal-stem-cell-mediated-t-cell-immunosuppression 10.29011/SCRT-119. 000019 |
| spellingShingle | Al-Graittee, Satar Jabbar Rahi Lawal, Hamza Ramasamy, Rajesh Mesenchymal stem cell-mediated T cell immunosuppression |
| title | Mesenchymal stem cell-mediated T cell immunosuppression |
| title_full | Mesenchymal stem cell-mediated T cell immunosuppression |
| title_fullStr | Mesenchymal stem cell-mediated T cell immunosuppression |
| title_full_unstemmed | Mesenchymal stem cell-mediated T cell immunosuppression |
| title_short | Mesenchymal stem cell-mediated T cell immunosuppression |
| title_sort | mesenchymal stem cell-mediated t cell immunosuppression |
| url | http://psasir.upm.edu.my/id/eprint/62394/ http://psasir.upm.edu.my/id/eprint/62394/ http://psasir.upm.edu.my/id/eprint/62394/ http://psasir.upm.edu.my/id/eprint/62394/1/Mesenchymal%20stem%20cell-mediated%20T%20cell%20immunosuppression.pdf |