Mathematical modeling for estrogenic activity prediction of 17β- estradiol and 17α-ethynylestradiol mixtures in wastewater treatment plants effluent
Steroid estrogens such as 17β-Estradiol (E2) and 17α-Ethynylestradiol (EE2) are highly potent estrogens that widely detected in environmental samples. Mathematical modelling such as concentration addition (CA) and estradiol equivalent concentration (EEQ) models are usually associated with measuring...
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Springer
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/62359/ http://psasir.upm.edu.my/id/eprint/62359/1/Mathematical%20modeling%20for%20estrogenic%20activity%20prediction%20of%2017%CE%B2estradiol%20and%2017%CE%B1-ethynylestradiol%20mixtures%20in%20wastewater%20treatment%20plants%20effluent.pdf |
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| author | Ting, Yien Fang Praveena, Sarva Mangala Aris, Ahmad Zaharin Syed Ismail, Sharifah Norkhadijah Rasdi, Irniza |
| author_facet | Ting, Yien Fang Praveena, Sarva Mangala Aris, Ahmad Zaharin Syed Ismail, Sharifah Norkhadijah Rasdi, Irniza |
| author_sort | Ting, Yien Fang |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Steroid estrogens such as 17β-Estradiol (E2) and 17α-Ethynylestradiol (EE2) are highly potent estrogens that widely detected in environmental samples. Mathematical modelling such as concentration addition (CA) and estradiol equivalent concentration (EEQ) models are usually associated with measuring techniques to assess risk, predict the mixture response and evaluate the estrogenic activity of mixture. Wastewater has played a crucial role because wastewater treatment plant (WWTP) is the major sources of estrogenic activity in aquatic environment. The aims of this is to determine E2 and EE2 concentrations in six WWTPs effluent, to predict the estrogenic activity of the WWTPs effluent using CA and EEQ models where lastly the effectiveness of two models is evaluated. Results showed that all the six WWTPs effluent had relative high E2 concentration (35.1–85.2 ng/L) compared to EE2 (0.02–1.0 ng/L). The estrogenic activity predicted by CA model was similar among the six WWTPs (105.4 ng/L), due to the similarity of individual dose potency ratio calculated by respective WWTPs. The predicted total EEQ was ranged from 35.1 EEQ-ng/L to 85.3 EEQ-ng/L, explained by high E2 concentration in WWTPs effluent and E2 EEF value that standardized to 1.0 μg/L. The CA model is more effective than EEQ model in estrogenic activity prediction because EEQ model used less data and causes disassociation from the predicted behavior. Although both models predicted relative high estrogenic activity in WWTPs effluent, dilution effects in receiving river may lower the estrogenic response to aquatic inhabitants. |
| first_indexed | 2025-11-15T11:12:39Z |
| format | Article |
| id | upm-62359 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:12:39Z |
| publishDate | 2017 |
| publisher | Springer |
| recordtype | eprints |
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| spelling | upm-623592020-01-08T01:32:19Z http://psasir.upm.edu.my/id/eprint/62359/ Mathematical modeling for estrogenic activity prediction of 17β- estradiol and 17α-ethynylestradiol mixtures in wastewater treatment plants effluent Ting, Yien Fang Praveena, Sarva Mangala Aris, Ahmad Zaharin Syed Ismail, Sharifah Norkhadijah Rasdi, Irniza Steroid estrogens such as 17β-Estradiol (E2) and 17α-Ethynylestradiol (EE2) are highly potent estrogens that widely detected in environmental samples. Mathematical modelling such as concentration addition (CA) and estradiol equivalent concentration (EEQ) models are usually associated with measuring techniques to assess risk, predict the mixture response and evaluate the estrogenic activity of mixture. Wastewater has played a crucial role because wastewater treatment plant (WWTP) is the major sources of estrogenic activity in aquatic environment. The aims of this is to determine E2 and EE2 concentrations in six WWTPs effluent, to predict the estrogenic activity of the WWTPs effluent using CA and EEQ models where lastly the effectiveness of two models is evaluated. Results showed that all the six WWTPs effluent had relative high E2 concentration (35.1–85.2 ng/L) compared to EE2 (0.02–1.0 ng/L). The estrogenic activity predicted by CA model was similar among the six WWTPs (105.4 ng/L), due to the similarity of individual dose potency ratio calculated by respective WWTPs. The predicted total EEQ was ranged from 35.1 EEQ-ng/L to 85.3 EEQ-ng/L, explained by high E2 concentration in WWTPs effluent and E2 EEF value that standardized to 1.0 μg/L. The CA model is more effective than EEQ model in estrogenic activity prediction because EEQ model used less data and causes disassociation from the predicted behavior. Although both models predicted relative high estrogenic activity in WWTPs effluent, dilution effects in receiving river may lower the estrogenic response to aquatic inhabitants. Springer 2017-10 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62359/1/Mathematical%20modeling%20for%20estrogenic%20activity%20prediction%20of%2017%CE%B2estradiol%20and%2017%CE%B1-ethynylestradiol%20mixtures%20in%20wastewater%20treatment%20plants%20effluent.pdf Ting, Yien Fang and Praveena, Sarva Mangala and Aris, Ahmad Zaharin and Syed Ismail, Sharifah Norkhadijah and Rasdi, Irniza (2017) Mathematical modeling for estrogenic activity prediction of 17β- estradiol and 17α-ethynylestradiol mixtures in wastewater treatment plants effluent. Ecotoxicology, 26 (10). 1327 - 1335. ISSN 0963-9292; ESSN: 1573-3017 https://link.springer.com/article/10.1007/s10646-017-1857-5 10.1007/s10646-017-1857-5 |
| spellingShingle | Ting, Yien Fang Praveena, Sarva Mangala Aris, Ahmad Zaharin Syed Ismail, Sharifah Norkhadijah Rasdi, Irniza Mathematical modeling for estrogenic activity prediction of 17β- estradiol and 17α-ethynylestradiol mixtures in wastewater treatment plants effluent |
| title | Mathematical modeling for estrogenic activity prediction of 17β- estradiol and 17α-ethynylestradiol mixtures in wastewater treatment plants effluent |
| title_full | Mathematical modeling for estrogenic activity prediction of 17β- estradiol and 17α-ethynylestradiol mixtures in wastewater treatment plants effluent |
| title_fullStr | Mathematical modeling for estrogenic activity prediction of 17β- estradiol and 17α-ethynylestradiol mixtures in wastewater treatment plants effluent |
| title_full_unstemmed | Mathematical modeling for estrogenic activity prediction of 17β- estradiol and 17α-ethynylestradiol mixtures in wastewater treatment plants effluent |
| title_short | Mathematical modeling for estrogenic activity prediction of 17β- estradiol and 17α-ethynylestradiol mixtures in wastewater treatment plants effluent |
| title_sort | mathematical modeling for estrogenic activity prediction of 17β- estradiol and 17α-ethynylestradiol mixtures in wastewater treatment plants effluent |
| url | http://psasir.upm.edu.my/id/eprint/62359/ http://psasir.upm.edu.my/id/eprint/62359/ http://psasir.upm.edu.my/id/eprint/62359/ http://psasir.upm.edu.my/id/eprint/62359/1/Mathematical%20modeling%20for%20estrogenic%20activity%20prediction%20of%2017%CE%B2estradiol%20and%2017%CE%B1-ethynylestradiol%20mixtures%20in%20wastewater%20treatment%20plants%20effluent.pdf |