Light chain multiple myeloma: an evaluation of its biochemical investigations
Multiple myeloma is a type of plasma cell dyscrasia, characterised by presence of paraprotein or monoclonal (M)-protein in serum or urine. The M-protein may consist of an intact immunoglobulin, the heavy chain only or the light chain only. The latter, designated as light chain multiple myeloma (LCMM...
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| Format: | Article |
| Language: | English |
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Malaysian Society of Pathologists
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/62306/ http://psasir.upm.edu.my/id/eprint/62306/1/Light%20chain%20multiple%20myeloma.pdf |
| _version_ | 1848854604010225664 |
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| author | Zahari Sham, Siti Yazmin Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Lim, Say Min |
| author_facet | Zahari Sham, Siti Yazmin Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Lim, Say Min |
| author_sort | Zahari Sham, Siti Yazmin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Multiple myeloma is a type of plasma cell dyscrasia, characterised by presence of paraprotein or monoclonal (M)-protein in serum or urine. The M-protein may consist of an intact immunoglobulin, the heavy chain only or the light chain only. The latter, designated as light chain multiple myeloma (LCMM) makes up almost 20% of myelomas. Clinical manifestation is often heralded by hypercalcaemia, renal impairment, normocytic normochromic anaemia and bone lesions, reflecting end-organ damage, collectively known as the acronym CRAB. In particular, free light chain nephrotoxicity accounts for the high prevalence of renal impairment seen in LCMM. This case illustrates a typical presentation of LCMM with focal discussion on its initial and diagnostic, as well as prognostic biochemical investigations. |
| first_indexed | 2025-11-15T11:12:30Z |
| format | Article |
| id | upm-62306 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:12:30Z |
| publishDate | 2017 |
| publisher | Malaysian Society of Pathologists |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-623062019-10-31T02:34:15Z http://psasir.upm.edu.my/id/eprint/62306/ Light chain multiple myeloma: an evaluation of its biochemical investigations Zahari Sham, Siti Yazmin Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Lim, Say Min Multiple myeloma is a type of plasma cell dyscrasia, characterised by presence of paraprotein or monoclonal (M)-protein in serum or urine. The M-protein may consist of an intact immunoglobulin, the heavy chain only or the light chain only. The latter, designated as light chain multiple myeloma (LCMM) makes up almost 20% of myelomas. Clinical manifestation is often heralded by hypercalcaemia, renal impairment, normocytic normochromic anaemia and bone lesions, reflecting end-organ damage, collectively known as the acronym CRAB. In particular, free light chain nephrotoxicity accounts for the high prevalence of renal impairment seen in LCMM. This case illustrates a typical presentation of LCMM with focal discussion on its initial and diagnostic, as well as prognostic biochemical investigations. Malaysian Society of Pathologists 2017-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62306/1/Light%20chain%20multiple%20myeloma.pdf Zahari Sham, Siti Yazmin and Chellappah Thambiah, Subashini and Samsudin, Intan Nureslyna and Lim, Say Min (2017) Light chain multiple myeloma: an evaluation of its biochemical investigations. The Malaysian Journal of Pathology, 39 (3). 311 - 315. ISSN 0126-8635 http://www.mjpath.org.my/2017/v39n3/index.php |
| spellingShingle | Zahari Sham, Siti Yazmin Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Lim, Say Min Light chain multiple myeloma: an evaluation of its biochemical investigations |
| title | Light chain multiple myeloma: an evaluation of its biochemical investigations |
| title_full | Light chain multiple myeloma: an evaluation of its biochemical investigations |
| title_fullStr | Light chain multiple myeloma: an evaluation of its biochemical investigations |
| title_full_unstemmed | Light chain multiple myeloma: an evaluation of its biochemical investigations |
| title_short | Light chain multiple myeloma: an evaluation of its biochemical investigations |
| title_sort | light chain multiple myeloma: an evaluation of its biochemical investigations |
| url | http://psasir.upm.edu.my/id/eprint/62306/ http://psasir.upm.edu.my/id/eprint/62306/ http://psasir.upm.edu.my/id/eprint/62306/1/Light%20chain%20multiple%20myeloma.pdf |