In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb
Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicletreated (...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer - Medknow Publications and Media
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/62141/ http://psasir.upm.edu.my/id/eprint/62141/1/In%20vivo%20study%20of%20tetraprenyltoluquinone%2C%20an%20anticancer%20compounds%20from%20Garcinia%20cowa%20Roxb.pdf |
| _version_ | 1848854569333817344 |
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| author | Wahyuni, Fatma Sri Lim, Siang Hui Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus |
| author_facet | Wahyuni, Fatma Sri Lim, Siang Hui Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus |
| author_sort | Wahyuni, Fatma Sri |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicletreated (10% tween 80) animals were used as control group. The tumor size and mice body weight were measured for 14 days. Results: Single treatment of 800 mg/kg of TPTQ displayed moderate antitumor activity against H-460 tumor xenografts as compared with vehicle-treated control. The mean time to reach RTV of 4 for vehicle-treated control group was 4.5 days whereas for TPTQ-treated (800 mg/kg) group was 9.5 days. Conclusion: The results showed that TPTQ slowed the tumor growth by 5 days. Thus, TPTQ may be considered as a promising compound in cancer chemotherapy. |
| first_indexed | 2025-11-15T11:11:57Z |
| format | Article |
| id | upm-62141 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:11:57Z |
| publishDate | 2017 |
| publisher | Wolters Kluwer - Medknow Publications and Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-621412019-04-16T03:51:36Z http://psasir.upm.edu.my/id/eprint/62141/ In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb Wahyuni, Fatma Sri Lim, Siang Hui Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicletreated (10% tween 80) animals were used as control group. The tumor size and mice body weight were measured for 14 days. Results: Single treatment of 800 mg/kg of TPTQ displayed moderate antitumor activity against H-460 tumor xenografts as compared with vehicle-treated control. The mean time to reach RTV of 4 for vehicle-treated control group was 4.5 days whereas for TPTQ-treated (800 mg/kg) group was 9.5 days. Conclusion: The results showed that TPTQ slowed the tumor growth by 5 days. Thus, TPTQ may be considered as a promising compound in cancer chemotherapy. Wolters Kluwer - Medknow Publications and Media 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/62141/1/In%20vivo%20study%20of%20tetraprenyltoluquinone%2C%20an%20anticancer%20compounds%20from%20Garcinia%20cowa%20Roxb.pdf Wahyuni, Fatma Sri and Lim, Siang Hui and Stanslas, Johnson and Lajis, Nordin and Hamidi, Dachriyanus (2017) In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb. Journal of Young Pharmacists, 9 (2). 296 - 298. ISSN 0975-1483; ESSN: 0975-1505 http://www.jyoungpharm.org/article/1003 10.5530/jyp.2017.9.58 |
| spellingShingle | Wahyuni, Fatma Sri Lim, Siang Hui Stanslas, Johnson Lajis, Nordin Hamidi, Dachriyanus In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb |
| title | In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb |
| title_full | In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb |
| title_fullStr | In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb |
| title_full_unstemmed | In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb |
| title_short | In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb |
| title_sort | in vivo study of tetraprenyltoluquinone, an anticancer compounds from garcinia cowa roxb |
| url | http://psasir.upm.edu.my/id/eprint/62141/ http://psasir.upm.edu.my/id/eprint/62141/ http://psasir.upm.edu.my/id/eprint/62141/ http://psasir.upm.edu.my/id/eprint/62141/1/In%20vivo%20study%20of%20tetraprenyltoluquinone%2C%20an%20anticancer%20compounds%20from%20Garcinia%20cowa%20Roxb.pdf |