Gadolinium-doped gallic acid-zinc/aluminium-layered double hydroxide/gold theranostic nanoparticles for a bimodal magnetic resonance imaging and drug delivery system
We have developed gadolinium-based theranostic nanoparticles for co-delivery of drug and magnetic resonance imaging (MRI) contrast agent using Zn/Al-layered double hydroxide as the nanocarrier platform, a naturally occurring phenolic compound, gallic acid (GA) as therapeutic agent, and Gd(NO3)3 as d...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61932/ http://psasir.upm.edu.my/id/eprint/61932/1/Gadolinium-based%20layered%20double%20hydroxide%20and%20graphene%20oxide%20nano-carriers%20for%20magnetic%20resonance%20imaging%20and%20drug%20delivery.pdf |
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| author | Usman, Muhammad Sani Hussein, Mohd Zobir Fakurazi, Sharida Masarudin, Mas Jaffri Ahmad Saad, Fathinul Fikri |
| author_facet | Usman, Muhammad Sani Hussein, Mohd Zobir Fakurazi, Sharida Masarudin, Mas Jaffri Ahmad Saad, Fathinul Fikri |
| author_sort | Usman, Muhammad Sani |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | We have developed gadolinium-based theranostic nanoparticles for co-delivery of drug and magnetic resonance imaging (MRI) contrast agent using Zn/Al-layered double hydroxide as the nanocarrier platform, a naturally occurring phenolic compound, gallic acid (GA) as therapeutic agent, and Gd(NO3)3 as diagnostic agent. Gold nanoparticles (AuNPs) were grown on the system
to support the contrast for MRI imaging. The nanoparticles were characterized using techniques such as Hi-TEM, XRD, ICP-ES. Kinetic release study of the GA from the nanoparticles showed about 70% of GA was released over a period of 72 h. The in vitro cell viability test for the nanoparticles showed relatively low toxicity to human cell lines (3T3) and improved toxicity on cancerous cell lines
(HepG2). A preliminary contrast property test of the nanoparticles, tested on a 3 Tesla MRI machine
at various concentrations of GAGZAu and water (as a reference) indicates that the nanoparticles have
a promising dual diagnostic and therapeutic features to further develop a better future for clinical
remedy for cancer treatment. |
| first_indexed | 2025-11-15T11:11:10Z |
| format | Article |
| id | upm-61932 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:11:10Z |
| publishDate | 2017 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-619322019-03-04T03:34:24Z http://psasir.upm.edu.my/id/eprint/61932/ Gadolinium-doped gallic acid-zinc/aluminium-layered double hydroxide/gold theranostic nanoparticles for a bimodal magnetic resonance imaging and drug delivery system Usman, Muhammad Sani Hussein, Mohd Zobir Fakurazi, Sharida Masarudin, Mas Jaffri Ahmad Saad, Fathinul Fikri We have developed gadolinium-based theranostic nanoparticles for co-delivery of drug and magnetic resonance imaging (MRI) contrast agent using Zn/Al-layered double hydroxide as the nanocarrier platform, a naturally occurring phenolic compound, gallic acid (GA) as therapeutic agent, and Gd(NO3)3 as diagnostic agent. Gold nanoparticles (AuNPs) were grown on the system to support the contrast for MRI imaging. The nanoparticles were characterized using techniques such as Hi-TEM, XRD, ICP-ES. Kinetic release study of the GA from the nanoparticles showed about 70% of GA was released over a period of 72 h. The in vitro cell viability test for the nanoparticles showed relatively low toxicity to human cell lines (3T3) and improved toxicity on cancerous cell lines (HepG2). A preliminary contrast property test of the nanoparticles, tested on a 3 Tesla MRI machine at various concentrations of GAGZAu and water (as a reference) indicates that the nanoparticles have a promising dual diagnostic and therapeutic features to further develop a better future for clinical remedy for cancer treatment. MDPI 2017-09 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61932/1/Gadolinium-based%20layered%20double%20hydroxide%20and%20graphene%20oxide%20nano-carriers%20for%20magnetic%20resonance%20imaging%20and%20drug%20delivery.pdf Usman, Muhammad Sani and Hussein, Mohd Zobir and Fakurazi, Sharida and Masarudin, Mas Jaffri and Ahmad Saad, Fathinul Fikri (2017) Gadolinium-doped gallic acid-zinc/aluminium-layered double hydroxide/gold theranostic nanoparticles for a bimodal magnetic resonance imaging and drug delivery system. Nanomaterials, 7 (9). pp. 1-16. ISSN 2079-4991 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618355/ 10.3390/nano7090244 |
| spellingShingle | Usman, Muhammad Sani Hussein, Mohd Zobir Fakurazi, Sharida Masarudin, Mas Jaffri Ahmad Saad, Fathinul Fikri Gadolinium-doped gallic acid-zinc/aluminium-layered double hydroxide/gold theranostic nanoparticles for a bimodal magnetic resonance imaging and drug delivery system |
| title | Gadolinium-doped gallic acid-zinc/aluminium-layered double hydroxide/gold theranostic nanoparticles for a bimodal magnetic resonance imaging and drug delivery system |
| title_full | Gadolinium-doped gallic acid-zinc/aluminium-layered double hydroxide/gold theranostic nanoparticles for a bimodal magnetic resonance imaging and drug delivery system |
| title_fullStr | Gadolinium-doped gallic acid-zinc/aluminium-layered double hydroxide/gold theranostic nanoparticles for a bimodal magnetic resonance imaging and drug delivery system |
| title_full_unstemmed | Gadolinium-doped gallic acid-zinc/aluminium-layered double hydroxide/gold theranostic nanoparticles for a bimodal magnetic resonance imaging and drug delivery system |
| title_short | Gadolinium-doped gallic acid-zinc/aluminium-layered double hydroxide/gold theranostic nanoparticles for a bimodal magnetic resonance imaging and drug delivery system |
| title_sort | gadolinium-doped gallic acid-zinc/aluminium-layered double hydroxide/gold theranostic nanoparticles for a bimodal magnetic resonance imaging and drug delivery system |
| url | http://psasir.upm.edu.my/id/eprint/61932/ http://psasir.upm.edu.my/id/eprint/61932/ http://psasir.upm.edu.my/id/eprint/61932/ http://psasir.upm.edu.my/id/eprint/61932/1/Gadolinium-based%20layered%20double%20hydroxide%20and%20graphene%20oxide%20nano-carriers%20for%20magnetic%20resonance%20imaging%20and%20drug%20delivery.pdf |