Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial
Tocotrienols, the unsaturated form of vitamin E, were reported to modulate platelet aggregation and thrombotic mechanisms in pre-clinical studies. Using a Food and Drug Administration (FDA)-approved cartridge-based measurement system, a randomised, double-blind, crossover and placebo-controlled tria...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61587/ http://psasir.upm.edu.my/id/eprint/61587/1/Effect%20of%20palm-based%20tocotrienols%20and%20tocopherol%20mixture%20supplementation%20on%20platelet%20aggregation%20in%20subjects%20with%20metabolic%20syndrome%2C%20a%20randomised%20controlled%20trial.pdf |
| _version_ | 1848854442258989056 |
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| author | Gan, Yee Lin Fu, Ju Yen Lai, Oi Ming Chew, Boon How Yuen, Kah Hay Teng, Kim Tiu Nesaretnam, Kalanithi Selvaduray, Kanga Rani Meganathan, Puvaneswari |
| author_facet | Gan, Yee Lin Fu, Ju Yen Lai, Oi Ming Chew, Boon How Yuen, Kah Hay Teng, Kim Tiu Nesaretnam, Kalanithi Selvaduray, Kanga Rani Meganathan, Puvaneswari |
| author_sort | Gan, Yee Lin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Tocotrienols, the unsaturated form of vitamin E, were reported to modulate platelet aggregation and thrombotic mechanisms in pre-clinical studies. Using a Food and Drug Administration (FDA)-approved cartridge-based measurement system, a randomised, double-blind, crossover and placebo-controlled trial involving 32 metabolic syndrome adults was conducted to investigate the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. The participants were supplemented with 200 mg (69% tocotrienols and 31% α-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days in a random order. After 14 days, each intervention was accompanied by a postprandial study, in which participants consumed 200 mg PTT mixture or placebo capsule after a meal. Blood samples were collected on day 0, day 14 and during postprandial for the measurement of platelet aggregation reactivity. Subjects went through a 15-day washout period before commencement of subsequent intervention. Fasting platelet aggregation reactivity stimulated with adenosine diphosphate (ADP) did not show substantial changes after supplementation with PTT mixture compared to placebo (p = 0.393). Concomitantly, changes in postprandial platelet aggregation reactivity remained similar between PTT mixture and placebo interventions (p = 0.408). The results of this study highlight the lack of inhibitory effect on platelet aggregation after short-term supplementation of PTT mixture in participants with metabolic syndrome. |
| first_indexed | 2025-11-15T11:09:56Z |
| format | Article |
| id | upm-61587 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:09:56Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-615872022-05-25T03:13:56Z http://psasir.upm.edu.my/id/eprint/61587/ Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial Gan, Yee Lin Fu, Ju Yen Lai, Oi Ming Chew, Boon How Yuen, Kah Hay Teng, Kim Tiu Nesaretnam, Kalanithi Selvaduray, Kanga Rani Meganathan, Puvaneswari Tocotrienols, the unsaturated form of vitamin E, were reported to modulate platelet aggregation and thrombotic mechanisms in pre-clinical studies. Using a Food and Drug Administration (FDA)-approved cartridge-based measurement system, a randomised, double-blind, crossover and placebo-controlled trial involving 32 metabolic syndrome adults was conducted to investigate the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. The participants were supplemented with 200 mg (69% tocotrienols and 31% α-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days in a random order. After 14 days, each intervention was accompanied by a postprandial study, in which participants consumed 200 mg PTT mixture or placebo capsule after a meal. Blood samples were collected on day 0, day 14 and during postprandial for the measurement of platelet aggregation reactivity. Subjects went through a 15-day washout period before commencement of subsequent intervention. Fasting platelet aggregation reactivity stimulated with adenosine diphosphate (ADP) did not show substantial changes after supplementation with PTT mixture compared to placebo (p = 0.393). Concomitantly, changes in postprandial platelet aggregation reactivity remained similar between PTT mixture and placebo interventions (p = 0.408). The results of this study highlight the lack of inhibitory effect on platelet aggregation after short-term supplementation of PTT mixture in participants with metabolic syndrome. Nature Publishing Group 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61587/1/Effect%20of%20palm-based%20tocotrienols%20and%20tocopherol%20mixture%20supplementation%20on%20platelet%20aggregation%20in%20subjects%20with%20metabolic%20syndrome%2C%20a%20randomised%20controlled%20trial.pdf Gan, Yee Lin and Fu, Ju Yen and Lai, Oi Ming and Chew, Boon How and Yuen, Kah Hay and Teng, Kim Tiu and Nesaretnam, Kalanithi and Selvaduray, Kanga Rani and Meganathan, Puvaneswari (2017) Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial. Scientific Reports, 7 (1). art. no. 11542. pp. 1-10. ISSN 2045-2322 https://www.nature.com/articles/s41598-017-11813-w 10.1038/s41598-017-11813-w |
| spellingShingle | Gan, Yee Lin Fu, Ju Yen Lai, Oi Ming Chew, Boon How Yuen, Kah Hay Teng, Kim Tiu Nesaretnam, Kalanithi Selvaduray, Kanga Rani Meganathan, Puvaneswari Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial |
| title | Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial |
| title_full | Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial |
| title_fullStr | Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial |
| title_full_unstemmed | Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial |
| title_short | Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial |
| title_sort | effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial |
| url | http://psasir.upm.edu.my/id/eprint/61587/ http://psasir.upm.edu.my/id/eprint/61587/ http://psasir.upm.edu.my/id/eprint/61587/ http://psasir.upm.edu.my/id/eprint/61587/1/Effect%20of%20palm-based%20tocotrienols%20and%20tocopherol%20mixture%20supplementation%20on%20platelet%20aggregation%20in%20subjects%20with%20metabolic%20syndrome%2C%20a%20randomised%20controlled%20trial.pdf |