Cysteinyl leukotrienes as biomarkers of effect in linking exposure to air pollutants and respiratory inflammation among school children
Background: Industrial activities contribute to poor air quality either directly or through background concentrations, bringing to fore health issues regarding the health effects of the release of malodourous air pollutants. Methods: This research focused on the effects of exposure of air pollutants...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer-Medknow
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61273/ http://psasir.upm.edu.my/id/eprint/61273/1/Cysteinyl%20leukotrienes%20as%20biomarkers%20of%20effect%20in%20linking%20exposure%20to%20air%20pollutants%20and%20respiratory%20inflammation%20among%20school%20children.pdf |
| _version_ | 1848854379705139200 |
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| author | Suhaimi, Nur Faseeha Jalaludin, Juliana Abu Bakar, Suhaili |
| author_facet | Suhaimi, Nur Faseeha Jalaludin, Juliana Abu Bakar, Suhaili |
| author_sort | Suhaimi, Nur Faseeha |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Industrial activities contribute to poor air quality either directly or through background concentrations, bringing to fore health issues regarding the health effects of the release of malodourous air pollutants. Methods: This research focused on the effects of exposure of air pollutants from industrial facilities and traffic on school children by using selected airway inflammation biomarker, cysteinyl leukotrienes (CysLTs), in sputum. Questionnaires adapted from the American Thoracic Society (ATS) and the International Study of Asthma and Allergies in Childhood (ISAAC) were used to compile respiratory symptoms, history of exposure, and demographic data. Results: CysLTs level measured by using enzyme.linked immunosorbent assay (ELISA) was higher in the exposed group (0.402 ± 0.389 ng/mL) than in the comparative group (0.191 ± 0.231 ng/mL). A strong, significant correlation was established between sulfur dioxide (SO2) (r = 0.924, P < 0.001) and particulate matter 2.5 (PM2.5) (r = 0.242, P = 0.014), with the levels of CysLTs among school children in exposed group. This study reveals that SO2 is the most significant factor that influenced CysLTs levels among school children at P less than 0.001. Conclusion: CysLTs are proven to be reliable biomarkers of airway inflammation in healthy children, whereas sputum method is proven to be a reliable, safe and noninvasive procedure for school children with their reproducibility and sensitivity as portrayed in this study. Thus, the findings provide fundamental aspects relevant to future interventions to healthy children living near an industrial area from the environmental scope. |
| first_indexed | 2025-11-15T11:08:56Z |
| format | Article |
| id | upm-61273 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:08:56Z |
| publishDate | 2017 |
| publisher | Wolters Kluwer-Medknow |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-612732018-09-06T00:14:55Z http://psasir.upm.edu.my/id/eprint/61273/ Cysteinyl leukotrienes as biomarkers of effect in linking exposure to air pollutants and respiratory inflammation among school children Suhaimi, Nur Faseeha Jalaludin, Juliana Abu Bakar, Suhaili Background: Industrial activities contribute to poor air quality either directly or through background concentrations, bringing to fore health issues regarding the health effects of the release of malodourous air pollutants. Methods: This research focused on the effects of exposure of air pollutants from industrial facilities and traffic on school children by using selected airway inflammation biomarker, cysteinyl leukotrienes (CysLTs), in sputum. Questionnaires adapted from the American Thoracic Society (ATS) and the International Study of Asthma and Allergies in Childhood (ISAAC) were used to compile respiratory symptoms, history of exposure, and demographic data. Results: CysLTs level measured by using enzyme.linked immunosorbent assay (ELISA) was higher in the exposed group (0.402 ± 0.389 ng/mL) than in the comparative group (0.191 ± 0.231 ng/mL). A strong, significant correlation was established between sulfur dioxide (SO2) (r = 0.924, P < 0.001) and particulate matter 2.5 (PM2.5) (r = 0.242, P = 0.014), with the levels of CysLTs among school children in exposed group. This study reveals that SO2 is the most significant factor that influenced CysLTs levels among school children at P less than 0.001. Conclusion: CysLTs are proven to be reliable biomarkers of airway inflammation in healthy children, whereas sputum method is proven to be a reliable, safe and noninvasive procedure for school children with their reproducibility and sensitivity as portrayed in this study. Thus, the findings provide fundamental aspects relevant to future interventions to healthy children living near an industrial area from the environmental scope. Wolters Kluwer-Medknow 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61273/1/Cysteinyl%20leukotrienes%20as%20biomarkers%20of%20effect%20in%20linking%20exposure%20to%20air%20pollutants%20and%20respiratory%20inflammation%20among%20school%20children.pdf Suhaimi, Nur Faseeha and Jalaludin, Juliana and Abu Bakar, Suhaili (2017) Cysteinyl leukotrienes as biomarkers of effect in linking exposure to air pollutants and respiratory inflammation among school children. Annals of Tropical Medicine and Public Health, 10 (2). 423 - 431. ISSN 1755-6783, ESSN: 0974-6005 10.4103/ATMPH.ATMPH_89_17 |
| spellingShingle | Suhaimi, Nur Faseeha Jalaludin, Juliana Abu Bakar, Suhaili Cysteinyl leukotrienes as biomarkers of effect in linking exposure to air pollutants and respiratory inflammation among school children |
| title | Cysteinyl leukotrienes as biomarkers of effect in linking exposure to air pollutants and respiratory inflammation among school children |
| title_full | Cysteinyl leukotrienes as biomarkers of effect in linking exposure to air pollutants and respiratory inflammation among school children |
| title_fullStr | Cysteinyl leukotrienes as biomarkers of effect in linking exposure to air pollutants and respiratory inflammation among school children |
| title_full_unstemmed | Cysteinyl leukotrienes as biomarkers of effect in linking exposure to air pollutants and respiratory inflammation among school children |
| title_short | Cysteinyl leukotrienes as biomarkers of effect in linking exposure to air pollutants and respiratory inflammation among school children |
| title_sort | cysteinyl leukotrienes as biomarkers of effect in linking exposure to air pollutants and respiratory inflammation among school children |
| url | http://psasir.upm.edu.my/id/eprint/61273/ http://psasir.upm.edu.my/id/eprint/61273/ http://psasir.upm.edu.my/id/eprint/61273/1/Cysteinyl%20leukotrienes%20as%20biomarkers%20of%20effect%20in%20linking%20exposure%20to%20air%20pollutants%20and%20respiratory%20inflammation%20among%20school%20children.pdf |