Curcumin, piperine, and capsaicin: a comparative study of spice-mediated inhibition of human cytochrome P450 isozyme activities

QR Code

Curcumin, piperine, and capsaicin: a comparative study of spice-mediated inhibition of human cytochrome P450 isozyme activities

Inhibition of cytochrome P450 (P450) enzymes (CYP) has been shown to lower the metabolism of drugs that are P450 substrates and to consequently alter their pharmacokinetic profiles. Curcumin (CUR), piperine (PIP), and capsaicin (CAP) are spice components (SC) that inhibit the activities of a range o...

Full description

Bibliographic Details
Main Authors:	Suhaili, Shamsi, Huong, Tran, Seok, Renee Jin Tan, Zee, Jian Tan, Lee, Yong Lim
Format:	Article
Language:	English
Published:	American Society for Pharmacology and Experimental Therapeutics (ASPET) 2017
Online Access:	http://psasir.upm.edu.my/id/eprint/61267/ http://psasir.upm.edu.my/id/eprint/61267/1/Curcumin%2C%20piperine%2C%20and%20capsaicin%20a%20comparative%20study%20of%20spice-mediated%20inhibition%20of%20human%20cytochrome%20P450%20isozyme%20activities.pdf

Similar Items

Investigating the size-dependent toxicological effects of zinc oxide nanoparticles on Caenorhabditis elegans and the inhibitory potential of Cytochrome P450 isozymes
by: Chowdhury, Lamia Noushin Sadeque
Published: (2024)

The Role of Drug Metabolites in the Inhibition of Cytochrome P450 Enzymes
by: Mikov, M., et al.
Published: (2017)

Characterisation of equine cytochrome P450s
by: Orr, Catherine
Published: (2016)

Characterization and biological properties of NanoCUR formulation and its effect on major human cytochrome P450 enzymes
by: Shamsi, S., et al.
Published: (2015)

Studies on Cytochrome P450 4X1
by: Al-Anizy, Mohammed
Published: (2005)

Studies of The Structure of Cytochrome P450 4A1
by: Fan, MingQi
Published: (2002)

Cytochrome P450-mediated metabolism and cytotoxicity in rat cultured hepatocytes
by: Hammond, Alison H.
Published: (1990)

The role of PPARa in Cytochrome P450 gene expression and DNA synthesis
by: Jeffery, Brett
Published: (2001)

Role of cytochrome P450 monooxygenase in the bioactivation of aflatoxin B1
by: Sureeporn Nualkaew,, et al.
Published: (2017)

Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis
by: Rasool, Saiema, et al.
Published: (2016)

Synthesis and Characterization of Molecular Imprinting Polymer Microspheres of Piperine: Extraction of Piperine from Spiked Urine
by: Roland, Rachel Marcella, et al.
Published: (2016)

Expression and functional analysis of a transgenic cytochrome P450 monooxygenase in Pueraria mirifica
by: Li, Xu, et al.
Published: (2017)

An in vitro study of stereoselectivity of cytochrome p450 enzymes in the metabolism of 3,4-methylenedioxymethamphetamine
by: Asim, Wan Raihana Wan Aasim @ Wan
Published: (2013)

A comparison of capsaicin and menthol as trigeminal modulators of salivary composition for use in oral care applications
by: Truong, Pham-Quynh-Huong
Published: (2023)

Development Of Edible Oleogel For Capsaicin Delivery
by: Wong, Kean Seng
Published: (2020)

Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls
by: Ward, Natalie, et al.
Published: (2011)

The Effects Of Selected Pesticides On Cytochrome P450 System And Acetylcholinesterase Activity In Haruan, Channa Striatus
by: Yu, Tian
Published: (2000)

Isozyme analysis of anaerobic rumen fungi and their relationship to aerobic chytrids
by: Ho, Y.W., et al.
Published: (1994)

Isozyme analysis and relationships among three species in Malaysian trichoderma isolates.
by: Siddique, Shafiquz zaman, et al.
Published: (2010)

Modulation of cytochrome P450s by strobilanthes crispus anticancer sub-fraction and its potential interaction with tamoxifen metabolism
by: Fen, Yong Ya
Published: (2020)

Capsaicin: current understanding in therapeutic effects, drug interaction, and bioavailability
by: Chan, Suk Huei, et al.
Published: (2020)

Identification and characterisation of single nucleotide polymorphisms in cytochrome P450 2D6 gene in Malaysian breast cancer patients
by: Chin, Fee Wai
Published: (2012)

Subcloning of cytochrome P450 2C19 (CYP2CL9) In escherichia coli strain BL21
by: Abdullah, Nur Azieyati
Published: (2011)

Isozyme analysis for characterization of Ganoderma strains from south‐east Asia
by: Miller, R. N. G., et al.
Published: (1995)

Effect of Green Tea and its bioactive compound, (-)- Epigallocatechin-3-Gallate, on Weight Reduction and on Cytochrome P450 / Ng Mei Fong
by: Ng, Mei Fong
Published: (2018)

Acetylcholinesterase and cytochrome P-450 activities of three-spot gourami (Trichogaster trichopterus) exposed to diazinon and chlorpyrifos / Fauziah binti Haji Mohd Jaafar.
by: Mohd Jaafar, Fauziah
Published: (1997)

Herbs and spices in aging
by: Mohamed, Suhaila
Published: (2014)

Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat
by: Alsalem, Mohammad, et al.
Published: (2016)

Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissue
by: Gibson, William, et al.
Published: (2009)

The relative efficacy of topical non-steroidal anti-inflammatory drugs and capsaicin in osteoarthritis
by: Persson, Monica S.M.
Published: (2019)

Comparative Study of Pulsed Microwave and Hydrodistillation Extraction of Piperine Oil from Black Pepper
by: Olalere, Olusegun Abayomi, et al.
Published: (2017)

Preliminary studies of isozyme patterns of isolates of colletotrichum gloeosporioides from host plants in Malaysia
by: S. Kanapathipillai, Vijaya
Published: (1995)

The antimalarial effect of curcumin is mediated by the inhibition of glycogen synthase kinase-3β
by: Ali, Amatul Hamizah, et al.
Published: (2017)

Effects of spice dust on lung functions and respiratory symptoms in spice factory workers in Selangor
by: Noor, Hamdan, et al.
Published: (2000)

JEE 450 - Sistem Kawalan
by: PPJJ, Pusat Pengajian Jarak Jauh
Published: (2004)

Formation of inclusion complex of curcumin and tetrahydrocurcumin prevents angiogenesis by inhibiting VEGF activity : an in-silico study
by: Dewi, Firli Rahmah Primula, et al.
Published: (2024)

Formation of inclusion complex of curcumin and tetrahydrocurcumin prevents angiogenesis by inhibiting VEGF activity: an in-silico study
by: Dewi, Firli Rahmah Primula, et al.
Published: (2024)

Capsaicin and dihydrocapsaicin determination in chili pepper genotypes using ultra-fast liquid chromatography
by: Usman, Magaji G., et al.
Published: (2014)

Production of 22-hydroxy-metabolites of vitamin D3 by cytochrome P450scc (CYP11A1) and analysis of their biological activities on skin cells
by: Tuckey, R., et al.
Published: (2011)

Production of 22-hydroxy-metabolites of vitamin D3 by cytochrome P450scc (CYP11A1) and analysis of their biological activities on skin cells
by: Tuckey, R., et al.
Published: (2011)