Characterisation, in-vitro and in-vivo evaluation of valproic acid-loaded nanoemulsion for improved brain bioavailability

QR Code

Characterisation, in-vitro and in-vivo evaluation of valproic acid-loaded nanoemulsion for improved brain bioavailability

OBJECTIVE: This study was aimed to investigate the potential of formulated valproic acid-encapsulated nanoemulsion (VANE) to improve the brain bioavailability of valproic acid (VPA). METHODS: Valproic acid-encapsulated nanoemulsions were formulated and physically characterised (osmolarity, viscosity...

Full description

Bibliographic Details
Main Authors:	Tan, Suk Fei, Kirby, Brian P., Stanslas, Johnson, Basri, Hamidon
Format:	Article
Language:	English
Published:	John Wiley & Sons 2017
Online Access:	http://psasir.upm.edu.my/id/eprint/61082/ http://psasir.upm.edu.my/id/eprint/61082/1/Characterisation%2C%20in-vitro%20and%20in-vivo%20evaluation%20of%20valproic%20acid-loaded%20nanoemulsion%20for%20improved%20brain%20bioavailability.pdf

Similar Items

Development, characterisation and translocation of valproic acid-encapsulated nanoemulsion across blood-brain barrier
by: Tan, Suk Fei
Published: (2017)

Ultrasonic emulsification of parenteral valproic acid-loaded nanoemulsion with response surface methodology and evaluation of its stability
by: Tan, Suk Fei, et al.
Published: (2016)

Nanoemulsion-based parenteral drug delivery system of carbamazepine: preparation, characterization, stability evaluation and blood-brain pharmacokinetics
by: Tan, Sim Ling, et al.
Published: (2015)

Formulation, characterization and in vivo evaluation of nanoemulsion for enhancing oral bioavailability of ibuprofen / Nurfazreen Anuar
by: Anuar, Nurfazreen
Published: (2015)

In Vitro blood-brain barrier models for neuroinfectious diseases: a narrative review
by: Badawi, Ahmad Hussein, et al.
Published: (2024)

Predicting the optimum compositions of a parenteral nanoemulsion system loaded with azithromycin antibiotic utilizing the artificial neural network model
by: S. Daood, Ghaidaa, et al.
Published: (2015)

In vitro evaluation of the inhalable quercetin loaded nanoemulsion for pulmonary delivery
by: Arbain, Noor Hafizah, et al.
Published: (2018)

Freeze-dried lopinavir-loaded nanostructured lipid carriers for enhanced cellular uptake and bioavailability: statistical optimization, in vitro and in vivo evaluations.
by: Khan, Arshad Ali, et al.
Published: (2019)

Fabrication of nanoemulsion loaded with cefuroxime for efficient translocation across the blood brain barrier
by: Harun, Siti Norhawani
Published: (2018)

Development of nanoemulsion for efficient brain parental delivery of cefuroxime: designs,characterizations,and pharmacokinetics
by: Harun, Siti Norhawani, et al.
Published: (2018)

Iron Bioavailability From Spirulina (Arthrospira Platensis) And Its Interactions With Other Dietary Factors In Vitro And In Vivo
by: Loh, Su Peng
Published: (2004)

The control of adult neural stem cell proliferation and cognition by valproic acid
by: Umka, Jariya.
Published: (2010)

A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism.
by: Chaliha, Devahuti, et al.
Published: (2020)

Preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable PLGA nanoparticles for improved oral bioavailability / Suhaili Zainal Abidin
by: Zainal Abidin, Suhaili
Published: (2013)

The effects of valproic acid on navi.5 gene expression in mda-mb- 231 cells
by: Kandivan, Hemalatha
Published: (2016)

Development of parenteral nanoemulsion systems loaded with carbamazepine for efficient blood-brain barrier crossing in epilepsy treatment
by: Tan, Sim Ling
Published: (2016)

Valproic acid and fatalities in children: a review of individual case safety reports in VigiBase
by: Star, Kristina, et al.
Published: (2014)

Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment
by: Musa, Siti Hajar, et al.
Published: (2013)

Correlation between in vitro tests for blood brain barrier penetration with in vivo gliclazide penetration
by: Lalic-Popovic, M., et al.
Published: (2013)

Preparation and optimization of ibuprofen-loaded nanoemulsion formulation
by: Shahidan, Nur Shahidah, et al.
Published: (2019)

Toxicity and teratogenicity effects of valproic acid on zebrafish (Danio rerio) embryos in relation to autism spectrum disorder
by: Saleh Hodin, Nur Atikah, et al.
Published: (2023)

Bioavailability of heavy metal in rice using in vitro digestion model
by: Omar, Noreen Adila, et al.
Published: (2013)

Comparison of the effect of calcium on the bioavailability of iron from Spirulina platensis and ferrous sulphate in vivo
by: Ismail, Maznah, et al.
Published: (2002)

A potential tocopherol acetate loaded palm oil esters-in-water nanoemulsions for nanocosmeceuticals
by: Teo, Brian Sheng Xian, et al.
Published: (2010)

In vitro safety evaluation of palm tocotrienol-rich fraction nanoemulsion for topical application
by: Azizul, Zafarizal Aldrin, et al.
Published: (2018)

Parenteral formulation of nanoemulsion loaded with chloramphenicol for meningitis treatment
by: Musa, Siti Hajar
Published: (2014)

Biocompatible nutmeg oil-loaded nanoemulsion as phyto-repellent
by: Mohd Narawi, Masturah, et al.
Published: (2020)

Nose to brain delivery of selegiline loaded PLGA/lipid nanoparticles : Synthesis, characterisation and brain pharmacokinetics evaluation
by: Raman, Subashini, et al.
Published: (2022)

Measuring macroscopic brain connections in vivo
by: Jbabdi, Saad, et al.
Published: (2015)

In-vitro gastrointestinal digestion of kenaf seed oil-in-water nanoemulsions
by: Cheong, Ai Mun, et al.
Published: (2016)

Optimization of hydrocortisone-loaded nanoemulsion formulation using d-optimal mixture design
by: Kong, W. Y., et al.
Published: (2018)

Determination Of Valproic Acid Reference Range And Predictors For Good Seizure Control Among Patients With Epilepsy At Hospital Kuala Lumpur
by: Mastura , Ahmad
Published: (2014)

Formation of stable palm kernel oil esters nanoemulsion system containing hydrocortisone
by: Da Costa, Stephanie, et al.
Published: (2014)

Comparing the calcium bioavailability from two types of nano-sized enriched milk using in-vivo assay
by: Erfanian, Arezoo, et al.
Published: (2017)

Optimization of quercetin loaded palm oil ester based nanoemulsion formulation for pulmonary delivery
by: Arbain, Noor Hafizah, et al.
Published: (2018)

Enhancement of physicochemical properties of nanocolloidal carrier loaded with cyclosporine for topical treatment of psoriasis: in vitro diffusion and in vivo hydrating action
by: Musa, Siti Hajar, et al.
Published: (2017)

Formulation, Characterisation And In Vitro Skin Irritation Studies Of Jasminum Officinale And Anthemis Nobilis Essential Oil Nanoemulsion For Aedes AEGYPTI Repellent Activity
by: Muttiah, Nithya Niranjini
Published: (2019)

In vitro kinetic release study, in vivo hydration and moisturizing effect of peel-off oil-in-water (O/W) nanoemulsion containing kojic monooleate for topical application
by: Nur Farzana Jaslina, et al.
Published: (2022)

The effects of MDMA on brain: An in vivo study in rats
by: Zakaria, Fatin Haniza, et al.
Published: (2018)

Stability of positively charged nanoemulsion formulation containing steroidal drug for effective transdermal application
by: Da Costa, Stephanie, et al.
Published: (2014)