Blood-brain barrier derangement after electrical brain stimulation
Noninvasive brain stimulation methods, including repetitive transcranial magnetic stimulation and transcranial direct current stimulation (tDCS), have received considerable attention in recent years for use in the study and treatment of neurological conditions. Of these methods, tDCS is considered p...
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| Format: | Article |
| Language: | English |
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Sciaccess Inc.
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/61020/ http://psasir.upm.edu.my/id/eprint/61020/1/Blood-brain%20barrier%20derangement%20after%20electrical%20brain%20stimulation.pdf |
| _version_ | 1848854320900997120 |
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| author | Watanabe, Yumiko Nik Abd Rahman, Nik Mohd Afizan Takashima, Ichiro |
| author_facet | Watanabe, Yumiko Nik Abd Rahman, Nik Mohd Afizan Takashima, Ichiro |
| author_sort | Watanabe, Yumiko |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Noninvasive brain stimulation methods, including repetitive transcranial magnetic stimulation and transcranial direct current stimulation (tDCS), have received considerable attention in recent years for use in the study and treatment of neurological conditions. Of these methods, tDCS is considered particularly promising due to its ease of use and ability to confer polarity-dependent effects on brain excitability, making it an excellent option for clinical treatment of neurological and psychiatric diseases. While generally regarded as safe when following standard protocols, the effects of tDCS on cerebral blood vessels and blood-brain barrier (BBB) functions remain poorly understood. Here, we provide an overview of tDCS in the context of BBB function, summarize the current literature, and discuss implications for future research. To date, no alterations or damage to the BBB have been reported after weak tDCS stimulations in human subjects; however, some animal studies have reported alterations to BBB function following increased tDCS intensity, with inconsistencies in the effective tDCS polarity used to produce these BBB disruptions between studies. Further research will be necessary to evaluate the effects of tDCS on the BBB under various conditions. Finally, we discuss the potential of tDCS for enhancing drug delivery to the central nervous system, which may become possible as we refine our understanding of the effects of tDCS on BBB permeability. |
| first_indexed | 2025-11-15T11:08:00Z |
| format | Article |
| id | upm-61020 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:08:00Z |
| publishDate | 2017 |
| publisher | Sciaccess Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-610202019-04-30T04:01:39Z http://psasir.upm.edu.my/id/eprint/61020/ Blood-brain barrier derangement after electrical brain stimulation Watanabe, Yumiko Nik Abd Rahman, Nik Mohd Afizan Takashima, Ichiro Noninvasive brain stimulation methods, including repetitive transcranial magnetic stimulation and transcranial direct current stimulation (tDCS), have received considerable attention in recent years for use in the study and treatment of neurological conditions. Of these methods, tDCS is considered particularly promising due to its ease of use and ability to confer polarity-dependent effects on brain excitability, making it an excellent option for clinical treatment of neurological and psychiatric diseases. While generally regarded as safe when following standard protocols, the effects of tDCS on cerebral blood vessels and blood-brain barrier (BBB) functions remain poorly understood. Here, we provide an overview of tDCS in the context of BBB function, summarize the current literature, and discuss implications for future research. To date, no alterations or damage to the BBB have been reported after weak tDCS stimulations in human subjects; however, some animal studies have reported alterations to BBB function following increased tDCS intensity, with inconsistencies in the effective tDCS polarity used to produce these BBB disruptions between studies. Further research will be necessary to evaluate the effects of tDCS on the BBB under various conditions. Finally, we discuss the potential of tDCS for enhancing drug delivery to the central nervous system, which may become possible as we refine our understanding of the effects of tDCS on BBB permeability. Sciaccess Inc. 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/61020/1/Blood-brain%20barrier%20derangement%20after%20electrical%20brain%20stimulation.pdf Watanabe, Yumiko and Nik Abd Rahman, Nik Mohd Afizan and Takashima, Ichiro (2017) Blood-brain barrier derangement after electrical brain stimulation. Journal of Neurology & Neuromedicine, 2 (10). pp. 1-5. ISSN 2572-942X http://www.jneurology.com/articles/bloodbrain-barrier-derangement-after-electrical-brain-stimulation.pdf |
| spellingShingle | Watanabe, Yumiko Nik Abd Rahman, Nik Mohd Afizan Takashima, Ichiro Blood-brain barrier derangement after electrical brain stimulation |
| title | Blood-brain barrier derangement after electrical brain stimulation |
| title_full | Blood-brain barrier derangement after electrical brain stimulation |
| title_fullStr | Blood-brain barrier derangement after electrical brain stimulation |
| title_full_unstemmed | Blood-brain barrier derangement after electrical brain stimulation |
| title_short | Blood-brain barrier derangement after electrical brain stimulation |
| title_sort | blood-brain barrier derangement after electrical brain stimulation |
| url | http://psasir.upm.edu.my/id/eprint/61020/ http://psasir.upm.edu.my/id/eprint/61020/ http://psasir.upm.edu.my/id/eprint/61020/1/Blood-brain%20barrier%20derangement%20after%20electrical%20brain%20stimulation.pdf |