Betanodavirus: dissection of the viral life cycle
Progressive research has been recently made in dissecting the molecular biology of Betanodavirus life cycle, the causative pathogen of viral encephalopathy and retinopathy in economic important marine fish species. Establishment of betanodavirus infectious clone allows the manipulation of virus geno...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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John Wiley & Sons
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/60993/ http://psasir.upm.edu.my/id/eprint/60993/1/Betanodavirus%20dissection%20of%20the%20viral%20life%20cycle.pdf |
| _version_ | 1848854315184160768 |
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| author | Low, C. F. Baharum, Syarul Nataqain Chee, H. Y. Mohd Zohdi, Rozaini Musa, Najiah |
| author_facet | Low, C. F. Baharum, Syarul Nataqain Chee, H. Y. Mohd Zohdi, Rozaini Musa, Najiah |
| author_sort | Low, C. F. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Progressive research has been recently made in dissecting the molecular biology of Betanodavirus life cycle, the causative pathogen of viral encephalopathy and retinopathy in economic important marine fish species. Establishment of betanodavirus infectious clone allows the manipulation of virus genome for functional genomic study, which elucidates the biological event of the viral life cycle at molecular level. The betanodavirus strategizes its replication by expressing anti-apoptosis/antinecrotic proteins to maintain the cell viability during early infection. Subsequently utilizes and controls the biological machinery of the infected cells for viral genome replication. Towards the late phase of infection, mass production of capsid protein for virion assembly induces the activation of host apoptosis pathway. It eventually leads to the cell lysis and death, which the lysis of cell contributes to the accomplishment of viral shedding that completes a viral life cycle. The recent efforts to dissect the entire betanodavirus life cycle are currently reviewed. |
| first_indexed | 2025-11-15T11:07:55Z |
| format | Article |
| id | upm-60993 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:07:55Z |
| publishDate | 2017 |
| publisher | John Wiley & Sons |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-609932019-01-31T08:57:14Z http://psasir.upm.edu.my/id/eprint/60993/ Betanodavirus: dissection of the viral life cycle Low, C. F. Baharum, Syarul Nataqain Chee, H. Y. Mohd Zohdi, Rozaini Musa, Najiah Progressive research has been recently made in dissecting the molecular biology of Betanodavirus life cycle, the causative pathogen of viral encephalopathy and retinopathy in economic important marine fish species. Establishment of betanodavirus infectious clone allows the manipulation of virus genome for functional genomic study, which elucidates the biological event of the viral life cycle at molecular level. The betanodavirus strategizes its replication by expressing anti-apoptosis/antinecrotic proteins to maintain the cell viability during early infection. Subsequently utilizes and controls the biological machinery of the infected cells for viral genome replication. Towards the late phase of infection, mass production of capsid protein for virion assembly induces the activation of host apoptosis pathway. It eventually leads to the cell lysis and death, which the lysis of cell contributes to the accomplishment of viral shedding that completes a viral life cycle. The recent efforts to dissect the entire betanodavirus life cycle are currently reviewed. John Wiley & Sons 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/60993/1/Betanodavirus%20dissection%20of%20the%20viral%20life%20cycle.pdf Low, C. F. and Baharum, Syarul Nataqain and Chee, H. Y. and Mohd Zohdi, Rozaini and Musa, Najiah (2017) Betanodavirus: dissection of the viral life cycle. Journal of Fish Diseases, 40 (11). 1489 - 1496. ISSN 0140-7775; ESSN: 1365-2761 https://onlinelibrary.wiley.com/doi/epdf/10.1111/jfd.12638 10.1111/jfd.12638 |
| spellingShingle | Low, C. F. Baharum, Syarul Nataqain Chee, H. Y. Mohd Zohdi, Rozaini Musa, Najiah Betanodavirus: dissection of the viral life cycle |
| title | Betanodavirus: dissection of the viral life cycle |
| title_full | Betanodavirus: dissection of the viral life cycle |
| title_fullStr | Betanodavirus: dissection of the viral life cycle |
| title_full_unstemmed | Betanodavirus: dissection of the viral life cycle |
| title_short | Betanodavirus: dissection of the viral life cycle |
| title_sort | betanodavirus: dissection of the viral life cycle |
| url | http://psasir.upm.edu.my/id/eprint/60993/ http://psasir.upm.edu.my/id/eprint/60993/ http://psasir.upm.edu.my/id/eprint/60993/ http://psasir.upm.edu.my/id/eprint/60993/1/Betanodavirus%20dissection%20of%20the%20viral%20life%20cycle.pdf |