Anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds
The present study describes the screening of eight herbs namely Cosmos caudatus, Pluchea indica, Lawsonia inermis, Carica papaya, Piper betle, Andrographis paniculata, Pereskia bleo, and Melicope lunu based on their anti-obesity and antioxidant activities. Out of all tested herbs, Cosmos caudatus de...
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/60890/ http://psasir.upm.edu.my/id/eprint/60890/1/Anti-obesity%20and%20antioxidant%20activities%20of%20selected%20medicinal%20plants%20and%20phytochemical%20profiling%20of%20bioactive%20compounds.pdf |
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| author | Abdul Rahman, Hafeedza Saari, Nazamid Abas, Faridah Ismail, Amin Mumtaz, Muhammad Waseem Abdul Hamid, Azizah |
| author_facet | Abdul Rahman, Hafeedza Saari, Nazamid Abas, Faridah Ismail, Amin Mumtaz, Muhammad Waseem Abdul Hamid, Azizah |
| author_sort | Abdul Rahman, Hafeedza |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The present study describes the screening of eight herbs namely Cosmos caudatus, Pluchea indica, Lawsonia inermis, Carica papaya, Piper betle, Andrographis paniculata, Pereskia bleo, and Melicope lunu based on their anti-obesity and antioxidant activities. Out of all tested herbs, Cosmos caudatus demonstrated excellent anti-obesity and antioxidant potential with pancreatic lipase inhibitory effect (21.7 ± 1.3%) and DPPH radical scavenging activity (IC50 value of 31.98 ± 1.22 µg/mL). Cosmos caudatus was selected for further studies and extracting solvent composition with best anti-obesity and antioxidant potential was identified. Hundred percent Cosmos caudatus ethanolic extract was found to be the most effective and showed highest anti-obesity and antioxidant activities. Moreover, metabolite profiling of Cosmos caudatus extract was also carried out using UHPLC-MS/MS. The analysis depicted the presence of quercetin-3-rhamnoside, catechin, kaempherol, kaempherol glucoside, quercetin, quercetin-3-glucoside, quercetin-O-pentoside, quercetin-rhamnosyl galactoside, quinic acid, 1-caffeyolquinic acid, monogalloyl glucose, and procyanidin B1. Results revealed Cosmos caudatus as promising medicinal plant for the development of new functional food with prodigious applications in obesity. |
| first_indexed | 2025-11-15T11:07:34Z |
| format | Article |
| id | upm-60890 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:07:34Z |
| publishDate | 2017 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-608902019-04-29T08:21:02Z http://psasir.upm.edu.my/id/eprint/60890/ Anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds Abdul Rahman, Hafeedza Saari, Nazamid Abas, Faridah Ismail, Amin Mumtaz, Muhammad Waseem Abdul Hamid, Azizah The present study describes the screening of eight herbs namely Cosmos caudatus, Pluchea indica, Lawsonia inermis, Carica papaya, Piper betle, Andrographis paniculata, Pereskia bleo, and Melicope lunu based on their anti-obesity and antioxidant activities. Out of all tested herbs, Cosmos caudatus demonstrated excellent anti-obesity and antioxidant potential with pancreatic lipase inhibitory effect (21.7 ± 1.3%) and DPPH radical scavenging activity (IC50 value of 31.98 ± 1.22 µg/mL). Cosmos caudatus was selected for further studies and extracting solvent composition with best anti-obesity and antioxidant potential was identified. Hundred percent Cosmos caudatus ethanolic extract was found to be the most effective and showed highest anti-obesity and antioxidant activities. Moreover, metabolite profiling of Cosmos caudatus extract was also carried out using UHPLC-MS/MS. The analysis depicted the presence of quercetin-3-rhamnoside, catechin, kaempherol, kaempherol glucoside, quercetin, quercetin-3-glucoside, quercetin-O-pentoside, quercetin-rhamnosyl galactoside, quinic acid, 1-caffeyolquinic acid, monogalloyl glucose, and procyanidin B1. Results revealed Cosmos caudatus as promising medicinal plant for the development of new functional food with prodigious applications in obesity. Taylor & Francis 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/60890/1/Anti-obesity%20and%20antioxidant%20activities%20of%20selected%20medicinal%20plants%20and%20phytochemical%20profiling%20of%20bioactive%20compounds.pdf Abdul Rahman, Hafeedza and Saari, Nazamid and Abas, Faridah and Ismail, Amin and Mumtaz, Muhammad Waseem and Abdul Hamid, Azizah (2017) Anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds. International Journal of Food Properties, 20 (11). 2616 - 2629. ISSN 1094-2912; ESSN: 1532-2386 https://www.tandfonline.com/doi/pdf/10.1080/10942912.2016.1247098?needAccess=true 10.1080/10942912.2016.1247098 |
| spellingShingle | Abdul Rahman, Hafeedza Saari, Nazamid Abas, Faridah Ismail, Amin Mumtaz, Muhammad Waseem Abdul Hamid, Azizah Anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds |
| title | Anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds |
| title_full | Anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds |
| title_fullStr | Anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds |
| title_full_unstemmed | Anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds |
| title_short | Anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds |
| title_sort | anti-obesity and antioxidant activities of selected medicinal plants and phytochemical profiling of bioactive compounds |
| url | http://psasir.upm.edu.my/id/eprint/60890/ http://psasir.upm.edu.my/id/eprint/60890/ http://psasir.upm.edu.my/id/eprint/60890/ http://psasir.upm.edu.my/id/eprint/60890/1/Anti-obesity%20and%20antioxidant%20activities%20of%20selected%20medicinal%20plants%20and%20phytochemical%20profiling%20of%20bioactive%20compounds.pdf |