Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect
Background Ardisia crispa Thunb A.DC (Myrsinaceae), commonly known as "hen's eyes", has been traditionally used in treating various inflammatory diseases. The present study evaluated anti-arthritic, gastroprotective and antioxidant activities of Ardisia crispa root hexane extract (ACR...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Walter de Gruyter GmbH
2017
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/60877/ http://psasir.upm.edu.my/id/eprint/60877/1/Antiarthritic%20and%20gastroprotective%20activities%20of%20Ardisia%20crispa%20root%20partially%20mediated%20via%20its%20antioxidant%20effect.pdf |
| _version_ | 1848854290517458944 |
|---|---|
| author | Abd Hamid @ Abdul Razak, Roslida Lau, Moi Fong Yeong, Looi Ting |
| author_facet | Abd Hamid @ Abdul Razak, Roslida Lau, Moi Fong Yeong, Looi Ting |
| author_sort | Abd Hamid @ Abdul Razak, Roslida |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background Ardisia crispa Thunb A.DC (Myrsinaceae), commonly known as "hen's eyes", has been traditionally used in treating various inflammatory diseases. The present study evaluated anti-arthritic, gastroprotective and antioxidant activities of Ardisia crispa root hexane extract (ACRH) in various animal models. Methods Anti-arthritic activity was evaluated in complete Freund adjuvant (CFA)-induced adjuvant arthritis and gastroprotective effect was studied in the ethanol-induced ulcer model in rats. ACRH was further isolated to yield quinone-rich fraction (QRF) and both were analyzed for their total phenolic content, total flavonoid content and antioxidant activities in various antioxidant assays. Both ACRH and QRF were also analyzed for the quinone composition via gas chromatography analysis. Results ACRH exerted significant reduction of IL-1β and TNF-α at a lower dose range in CFA-induced arthritis, as well as exhibited its cytoprotective effect against ethanol-induced ulcer lesion via involvement of mucosal nonprotein sulfhydryl (NP-SH) groups. ACRH also showed higher phenolic and flavonoid contents, as well as better antioxidant activities than QRF. Conclusions These findings demonstrated the plant as a potential anti-inflammatory agent, with ACRH succeeded in inhibiting both arthritic and ulcerogenic effect, possibly mediated via its antioxidant effect. |
| first_indexed | 2025-11-15T11:07:31Z |
| format | Article |
| id | upm-60877 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:07:31Z |
| publishDate | 2017 |
| publisher | Walter de Gruyter GmbH |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-608772019-03-26T08:33:55Z http://psasir.upm.edu.my/id/eprint/60877/ Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect Abd Hamid @ Abdul Razak, Roslida Lau, Moi Fong Yeong, Looi Ting Background Ardisia crispa Thunb A.DC (Myrsinaceae), commonly known as "hen's eyes", has been traditionally used in treating various inflammatory diseases. The present study evaluated anti-arthritic, gastroprotective and antioxidant activities of Ardisia crispa root hexane extract (ACRH) in various animal models. Methods Anti-arthritic activity was evaluated in complete Freund adjuvant (CFA)-induced adjuvant arthritis and gastroprotective effect was studied in the ethanol-induced ulcer model in rats. ACRH was further isolated to yield quinone-rich fraction (QRF) and both were analyzed for their total phenolic content, total flavonoid content and antioxidant activities in various antioxidant assays. Both ACRH and QRF were also analyzed for the quinone composition via gas chromatography analysis. Results ACRH exerted significant reduction of IL-1β and TNF-α at a lower dose range in CFA-induced arthritis, as well as exhibited its cytoprotective effect against ethanol-induced ulcer lesion via involvement of mucosal nonprotein sulfhydryl (NP-SH) groups. ACRH also showed higher phenolic and flavonoid contents, as well as better antioxidant activities than QRF. Conclusions These findings demonstrated the plant as a potential anti-inflammatory agent, with ACRH succeeded in inhibiting both arthritic and ulcerogenic effect, possibly mediated via its antioxidant effect. Walter de Gruyter GmbH 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/60877/1/Antiarthritic%20and%20gastroprotective%20activities%20of%20Ardisia%20crispa%20root%20partially%20mediated%20via%20its%20antioxidant%20effect.pdf Abd Hamid @ Abdul Razak, Roslida and Lau, Moi Fong and Yeong, Looi Ting (2017) Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect. Journal of Complementary and Integrative Medicine, 15 (1). ISSN 2194-6329; ESSN: 1553-3840 10.1515/jcim-2017-0012 |
| spellingShingle | Abd Hamid @ Abdul Razak, Roslida Lau, Moi Fong Yeong, Looi Ting Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect |
| title | Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect |
| title_full | Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect |
| title_fullStr | Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect |
| title_full_unstemmed | Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect |
| title_short | Antiarthritic and gastroprotective activities of Ardisia crispa root partially mediated via its antioxidant effect |
| title_sort | antiarthritic and gastroprotective activities of ardisia crispa root partially mediated via its antioxidant effect |
| url | http://psasir.upm.edu.my/id/eprint/60877/ http://psasir.upm.edu.my/id/eprint/60877/ http://psasir.upm.edu.my/id/eprint/60877/1/Antiarthritic%20and%20gastroprotective%20activities%20of%20Ardisia%20crispa%20root%20partially%20mediated%20via%20its%20antioxidant%20effect.pdf |