Andrographolide restores healthy airway function in toluene diisocyanate-induced occupational mouse asthma model through upregulation of heam oxygenase-1 and activation of Akt/Nrf-2 dependent pathway

Andrographolide restores healthy airway function in toluene diisocyanate-induced occupational mouse asthma model through upregulation of heam oxygenase-1 and activation of Akt/Nrf-2 dependent pathway

Toluene diisocyanate (TDI) is a major cause of chemical-induced occupational asthma, which contributes about 15% of global asthma burden. Steroid resistance and compounded side effects that are associated with use of corticosteroid in management of asthma necessitate the search for alternative drugs...

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Bibliographic Details
Main Authors: Sulaiman, Ibrahim, Tan, Khaishin, Mohtaruddin, Norhafizah, Lim, Jonathan Chee Woei, Stanslas, Johnson
Format: Article
Language:English
Published: Federation of American Societies for Experimental Biology 2017
Online Access:http://psasir.upm.edu.my/id/eprint/60865/
http://psasir.upm.edu.my/id/eprint/60865/1/Andrographolide%20restores%20healthy%20airway%20function%20in%20toluene%20diisocyanate-induced%20occupational%20mouse%20asthma%20model%20through%20upregulation%20of%20heam%20oxygenase-1%20and%20activation%20of%20AktNrf-2%20dependent%20pathway.pdf

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