Preparation and characterization of CU-, FE-, AG-, ZN- and NI- doped gelatin nanofibers for possible applications in antibacterial nanomedicine
A facile and efficient approach to prepare metal nanoparticles doped electrospun gelatin from metal salts precursors was successfully developed. The incorporation of metal ions with antimicrobial activity into electrospun gelatin (Ge-espun) is an attractive approach to control the inflammatory react...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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School of Engineering, Taylor's University College
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/60462/ http://psasir.upm.edu.my/id/eprint/60462/1/Preparation%20and%20characterization%20of%20CU-%2C%20FE-%2C%20AG-%2C%20ZN-%20and%20NI-%20doped%20gelatin%20nanofibers%20for%20possible%20applications%20in%20antibacterial%20nanomedicine.pdf |
| _version_ | 1848854201408421888 |
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| author | Nuge, Tamrin Tshai, Kim Yeow Lim, Siew Shee Nordin, Norshariza Hoque, Md. Enamul |
| author_facet | Nuge, Tamrin Tshai, Kim Yeow Lim, Siew Shee Nordin, Norshariza Hoque, Md. Enamul |
| author_sort | Nuge, Tamrin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A facile and efficient approach to prepare metal nanoparticles doped electrospun gelatin from metal salts precursors was successfully developed. The incorporation of metal ions with antimicrobial activity into electrospun gelatin (Ge-espun) is an attractive approach to control the inflammatory reaction and prevent infection in wound. In this study, metal salts precursors AgNO3, Fe(NO3)3.9H2O, Cu(NO3)2.3H2O, Zn(NO3)2.6H2O and Ni(NO3)2.6H2O were reduced to metal nanoparticles with acetic acid as solvent and reducing agent. The agglomeration of nanoparticles was inhibited by the gelatin polymer matrix. Electrospinning of both neat Ge-espun and metal-nanoparticles/Ge-espun resulted in the formation of smooth fibres with average diameters of ~280nm and ~40nm-150nm, respectively. The efficacy of metal nanoparticles/Ge-espun against bacteria commonly found on wounds was tested with different metal loading by measuring the inhibition of colony forming units. The results indicated a broad spectrum of antibacterial activity showed by Ag/Ge-espun, followed by Fe/Ge-espun and Zn/Ge-espun. An interesting finding on the efficacy of Cu/Ge-espun and Fe/Ge-espun against the Gram’s positive bacteria is worth exploring to further investigate the potential application of metal-based antibiotics against the antibiotic-resistant bacterial strains. |
| first_indexed | 2025-11-15T11:06:06Z |
| format | Article |
| id | upm-60462 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:06:06Z |
| publishDate | 2017 |
| publisher | School of Engineering, Taylor's University College |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-604622018-05-21T03:51:25Z http://psasir.upm.edu.my/id/eprint/60462/ Preparation and characterization of CU-, FE-, AG-, ZN- and NI- doped gelatin nanofibers for possible applications in antibacterial nanomedicine Nuge, Tamrin Tshai, Kim Yeow Lim, Siew Shee Nordin, Norshariza Hoque, Md. Enamul A facile and efficient approach to prepare metal nanoparticles doped electrospun gelatin from metal salts precursors was successfully developed. The incorporation of metal ions with antimicrobial activity into electrospun gelatin (Ge-espun) is an attractive approach to control the inflammatory reaction and prevent infection in wound. In this study, metal salts precursors AgNO3, Fe(NO3)3.9H2O, Cu(NO3)2.3H2O, Zn(NO3)2.6H2O and Ni(NO3)2.6H2O were reduced to metal nanoparticles with acetic acid as solvent and reducing agent. The agglomeration of nanoparticles was inhibited by the gelatin polymer matrix. Electrospinning of both neat Ge-espun and metal-nanoparticles/Ge-espun resulted in the formation of smooth fibres with average diameters of ~280nm and ~40nm-150nm, respectively. The efficacy of metal nanoparticles/Ge-espun against bacteria commonly found on wounds was tested with different metal loading by measuring the inhibition of colony forming units. The results indicated a broad spectrum of antibacterial activity showed by Ag/Ge-espun, followed by Fe/Ge-espun and Zn/Ge-espun. An interesting finding on the efficacy of Cu/Ge-espun and Fe/Ge-espun against the Gram’s positive bacteria is worth exploring to further investigate the potential application of metal-based antibiotics against the antibiotic-resistant bacterial strains. School of Engineering, Taylor's University College 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/60462/1/Preparation%20and%20characterization%20of%20CU-%2C%20FE-%2C%20AG-%2C%20ZN-%20and%20NI-%20doped%20gelatin%20nanofibers%20for%20possible%20applications%20in%20antibacterial%20nanomedicine.pdf Nuge, Tamrin and Tshai, Kim Yeow and Lim, Siew Shee and Nordin, Norshariza and Hoque, Md. Enamul (2017) Preparation and characterization of CU-, FE-, AG-, ZN- and NI- doped gelatin nanofibers for possible applications in antibacterial nanomedicine. Journal of Engineering Science and Technology, 12 (spec. Mar.). pp. 68-81. ISSN 1823-4690 http://jestec.taylors.edu.my/Special%20Issues%202017.htm |
| spellingShingle | Nuge, Tamrin Tshai, Kim Yeow Lim, Siew Shee Nordin, Norshariza Hoque, Md. Enamul Preparation and characterization of CU-, FE-, AG-, ZN- and NI- doped gelatin nanofibers for possible applications in antibacterial nanomedicine |
| title | Preparation and characterization of CU-, FE-, AG-, ZN- and NI- doped gelatin nanofibers for possible applications in antibacterial nanomedicine |
| title_full | Preparation and characterization of CU-, FE-, AG-, ZN- and NI- doped gelatin nanofibers for possible applications in antibacterial nanomedicine |
| title_fullStr | Preparation and characterization of CU-, FE-, AG-, ZN- and NI- doped gelatin nanofibers for possible applications in antibacterial nanomedicine |
| title_full_unstemmed | Preparation and characterization of CU-, FE-, AG-, ZN- and NI- doped gelatin nanofibers for possible applications in antibacterial nanomedicine |
| title_short | Preparation and characterization of CU-, FE-, AG-, ZN- and NI- doped gelatin nanofibers for possible applications in antibacterial nanomedicine |
| title_sort | preparation and characterization of cu-, fe-, ag-, zn- and ni- doped gelatin nanofibers for possible applications in antibacterial nanomedicine |
| url | http://psasir.upm.edu.my/id/eprint/60462/ http://psasir.upm.edu.my/id/eprint/60462/ http://psasir.upm.edu.my/id/eprint/60462/1/Preparation%20and%20characterization%20of%20CU-%2C%20FE-%2C%20AG-%2C%20ZN-%20and%20NI-%20doped%20gelatin%20nanofibers%20for%20possible%20applications%20in%20antibacterial%20nanomedicine.pdf |