Mesenchymal stem cells: from stem cells to sarcomas
Mesenchymal stem cells (MSCs) have garnered vast interests in clinical settings, especially in regenerative medicine due to their unique properties—they are reliably isolated and expanded from various tissue sources; they are able to differentiate into mesodermal tissues such as bones, cartilages, a...
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| Format: | Article |
| Language: | English |
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International Federation for Cell Biology
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/59678/ http://psasir.upm.edu.my/id/eprint/59678/1/Mesenchymal%20stem%20cells%20from%20stem%20cells%20to%20sarcomas.pdf |
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| author | Lye, Kwan Liang Nordin, Norshariza Vidyadaran, Sharmili Karuppiah, Thilakavathy |
| author_facet | Lye, Kwan Liang Nordin, Norshariza Vidyadaran, Sharmili Karuppiah, Thilakavathy |
| author_sort | Lye, Kwan Liang |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Mesenchymal stem cells (MSCs) have garnered vast interests in clinical settings, especially in regenerative medicine due to their unique properties—they are reliably isolated and expanded from various tissue sources; they are able to differentiate into mesodermal tissues such as bones, cartilages, adipose tissues, and muscles; and they have unique immunosuppressive properties. However, there are some concerns pertaining to the role of MSCs in the human body. On one hand, they are crucial component in the regeneration and repair of the human body. On the contrary, they are shown to transform into sarcomas. Although the exact mechanisms are still unknown, many new leads have pointed to the belief that MSCs do play a role in sarcomagenesis. This review focuses on the current updates and findings of the role of MSCs in their transformation process into sarcomas. |
| first_indexed | 2025-11-15T11:02:43Z |
| format | Article |
| id | upm-59678 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:02:43Z |
| publishDate | 2016 |
| publisher | International Federation for Cell Biology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-596782018-03-16T00:41:11Z http://psasir.upm.edu.my/id/eprint/59678/ Mesenchymal stem cells: from stem cells to sarcomas Lye, Kwan Liang Nordin, Norshariza Vidyadaran, Sharmili Karuppiah, Thilakavathy Mesenchymal stem cells (MSCs) have garnered vast interests in clinical settings, especially in regenerative medicine due to their unique properties—they are reliably isolated and expanded from various tissue sources; they are able to differentiate into mesodermal tissues such as bones, cartilages, adipose tissues, and muscles; and they have unique immunosuppressive properties. However, there are some concerns pertaining to the role of MSCs in the human body. On one hand, they are crucial component in the regeneration and repair of the human body. On the contrary, they are shown to transform into sarcomas. Although the exact mechanisms are still unknown, many new leads have pointed to the belief that MSCs do play a role in sarcomagenesis. This review focuses on the current updates and findings of the role of MSCs in their transformation process into sarcomas. International Federation for Cell Biology 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/59678/1/Mesenchymal%20stem%20cells%20from%20stem%20cells%20to%20sarcomas.pdf Lye, Kwan Liang and Nordin, Norshariza and Vidyadaran, Sharmili and Karuppiah, Thilakavathy (2016) Mesenchymal stem cells: from stem cells to sarcomas. Cell Biology International, 40 (6). pp. 610-618. ISSN 1065-6995; ESSN: 1095-8355 http://onlinelibrary.wiley.com/wol1/doi/10.1002/cbin.10603/abstract 10.1002/cbin.10603 |
| spellingShingle | Lye, Kwan Liang Nordin, Norshariza Vidyadaran, Sharmili Karuppiah, Thilakavathy Mesenchymal stem cells: from stem cells to sarcomas |
| title | Mesenchymal stem cells: from stem cells to sarcomas |
| title_full | Mesenchymal stem cells: from stem cells to sarcomas |
| title_fullStr | Mesenchymal stem cells: from stem cells to sarcomas |
| title_full_unstemmed | Mesenchymal stem cells: from stem cells to sarcomas |
| title_short | Mesenchymal stem cells: from stem cells to sarcomas |
| title_sort | mesenchymal stem cells: from stem cells to sarcomas |
| url | http://psasir.upm.edu.my/id/eprint/59678/ http://psasir.upm.edu.my/id/eprint/59678/ http://psasir.upm.edu.my/id/eprint/59678/ http://psasir.upm.edu.my/id/eprint/59678/1/Mesenchymal%20stem%20cells%20from%20stem%20cells%20to%20sarcomas.pdf |