Liposome encapsulation: a promising approach to enhanced and safe mefenamic acid therapy
Mefenamic acid (MEF) is a non-steroidal anti-inflammatory drug (NSAID) characterized by low bioavailability with relative high toxicity. Despite the efforts which have been paid to enhance its bioavailability, its inherent toxicity remains the limiting factor for its medical uses. Designing MFE as a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Malaysia Association of Research and Education for Educators
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/59391/ http://psasir.upm.edu.my/id/eprint/59391/1/Liposome%20encapsulation%20a%20promising%20approach%20to%20enhanced%20and%20safe%20mefenamic%20acid%20therapy.pdf |
| _version_ | 1848853907428605952 |
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| author | Jarrar, Qais Bashir Mahmoud Ahmad, Zuraini Abdul Kadir, Arifah Zakaria, Zainul Amiruddin Abdullah, Muhammad Nazrul Hakim |
| author_facet | Jarrar, Qais Bashir Mahmoud Ahmad, Zuraini Abdul Kadir, Arifah Zakaria, Zainul Amiruddin Abdullah, Muhammad Nazrul Hakim |
| author_sort | Jarrar, Qais Bashir Mahmoud |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Mefenamic acid (MEF) is a non-steroidal anti-inflammatory drug (NSAID) characterized by low bioavailability with relative high toxicity. Despite the efforts which have been paid to enhance its bioavailability, its inherent toxicity remains the limiting factor for its medical uses. Designing MFE as a prodrug of ester derivatives can attenuate gastrointestinal (GI) toxicity, but shows no advantages in term of therapeutic efficacy. Liposomes have a dual action and would be a promising tool to enhance MFE bioavailability and reduce its gastric and systemic adverse reactions. This review covers the pharmacological and toxicological aspects of MFE and provides substantial trend to enhance its clinical therapy. |
| first_indexed | 2025-11-15T11:01:26Z |
| format | Article |
| id | upm-59391 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:01:26Z |
| publishDate | 2017 |
| publisher | Malaysia Association of Research and Education for Educators |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-593912018-03-01T02:46:19Z http://psasir.upm.edu.my/id/eprint/59391/ Liposome encapsulation: a promising approach to enhanced and safe mefenamic acid therapy Jarrar, Qais Bashir Mahmoud Ahmad, Zuraini Abdul Kadir, Arifah Zakaria, Zainul Amiruddin Abdullah, Muhammad Nazrul Hakim Mefenamic acid (MEF) is a non-steroidal anti-inflammatory drug (NSAID) characterized by low bioavailability with relative high toxicity. Despite the efforts which have been paid to enhance its bioavailability, its inherent toxicity remains the limiting factor for its medical uses. Designing MFE as a prodrug of ester derivatives can attenuate gastrointestinal (GI) toxicity, but shows no advantages in term of therapeutic efficacy. Liposomes have a dual action and would be a promising tool to enhance MFE bioavailability and reduce its gastric and systemic adverse reactions. This review covers the pharmacological and toxicological aspects of MFE and provides substantial trend to enhance its clinical therapy. Malaysia Association of Research and Education for Educators 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/59391/1/Liposome%20encapsulation%20a%20promising%20approach%20to%20enhanced%20and%20safe%20mefenamic%20acid%20therapy.pdf Jarrar, Qais Bashir Mahmoud and Ahmad, Zuraini and Abdul Kadir, Arifah and Zakaria, Zainul Amiruddin and Abdullah, Muhammad Nazrul Hakim (2017) Liposome encapsulation: a promising approach to enhanced and safe mefenamic acid therapy. International Research Journal of Education and Sciences, 1 (1). pp. 32-39. ISSN 2550-2158 http://www.masree.info/journal/irjes/2017-vol-1-issue-1/ |
| spellingShingle | Jarrar, Qais Bashir Mahmoud Ahmad, Zuraini Abdul Kadir, Arifah Zakaria, Zainul Amiruddin Abdullah, Muhammad Nazrul Hakim Liposome encapsulation: a promising approach to enhanced and safe mefenamic acid therapy |
| title | Liposome encapsulation: a promising approach to enhanced and safe mefenamic acid therapy |
| title_full | Liposome encapsulation: a promising approach to enhanced and safe mefenamic acid therapy |
| title_fullStr | Liposome encapsulation: a promising approach to enhanced and safe mefenamic acid therapy |
| title_full_unstemmed | Liposome encapsulation: a promising approach to enhanced and safe mefenamic acid therapy |
| title_short | Liposome encapsulation: a promising approach to enhanced and safe mefenamic acid therapy |
| title_sort | liposome encapsulation: a promising approach to enhanced and safe mefenamic acid therapy |
| url | http://psasir.upm.edu.my/id/eprint/59391/ http://psasir.upm.edu.my/id/eprint/59391/ http://psasir.upm.edu.my/id/eprint/59391/1/Liposome%20encapsulation%20a%20promising%20approach%20to%20enhanced%20and%20safe%20mefenamic%20acid%20therapy.pdf |