Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica
Six anthraquinones (nordamnacanthal, alizarin-1-methyl ether, rubiadin, soranjidiol, lucidin-ω-methyl ether and morindone) isolated from the cell suspension culture of Morinda elliptica were assayed for antitumor promoting and antioxidant activities. All compounds exhibited strong antitumor promotin...
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| Format: | Article |
| Language: | English |
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Malaysian Society for Molecular Biology and Biotechnology
2003
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| Online Access: | http://psasir.upm.edu.my/id/eprint/58528/ http://psasir.upm.edu.my/id/eprint/58528/1/Antitumor%20promoting%20and%20actioxidant%20activities%20of%20anthraquinones%20isolated%20from%20the%20cell%20suspension%20culture%20of%20Morinda%20elliptica.pdf |
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| author | Jasril, Lajis, Md. Nordin Lim, Yang Mooi Abdullah, Mohd Azmuddin Sukari, Mohd Aspollah Ali, Abdul Manaf |
| author_facet | Jasril, Lajis, Md. Nordin Lim, Yang Mooi Abdullah, Mohd Azmuddin Sukari, Mohd Aspollah Ali, Abdul Manaf |
| author_sort | Jasril, |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Six anthraquinones (nordamnacanthal, alizarin-1-methyl ether, rubiadin, soranjidiol, lucidin-ω-methyl ether and morindone) isolated from the cell suspension culture of Morinda elliptica were assayed for antitumor promoting and antioxidant activities. All compounds exhibited strong antitumor promoting activity at the concentration of 2.0 μg/ml when assayed using the inhibition test of Epstein Barr Virus (EBV) activation on Raji cells. At the concentration of 0.4 μg/ml, only nordamnacanthal exhibited strong antitumor promoting activity with the inhibition rate and the cell viability of 75.0% and 75.8%, respectively, which was stronger than the reference compounds genistein and quercetin. In antioxidant assay using ferric thiocyanate (FTC) method, nordamnacanthal and morindone showed stronger antioxidant activity than α-tocopherol. However when the compounds were assayed for scavenging activity of the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, only morindone was considered to be active as free radical scavenger with fifty percent inhibition concentration (IC50) of 40.6 μg/ml. |
| first_indexed | 2025-11-15T10:57:41Z |
| format | Article |
| id | upm-58528 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:57:41Z |
| publishDate | 2003 |
| publisher | Malaysian Society for Molecular Biology and Biotechnology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-585282018-01-22T03:13:58Z http://psasir.upm.edu.my/id/eprint/58528/ Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica Jasril, Lajis, Md. Nordin Lim, Yang Mooi Abdullah, Mohd Azmuddin Sukari, Mohd Aspollah Ali, Abdul Manaf Six anthraquinones (nordamnacanthal, alizarin-1-methyl ether, rubiadin, soranjidiol, lucidin-ω-methyl ether and morindone) isolated from the cell suspension culture of Morinda elliptica were assayed for antitumor promoting and antioxidant activities. All compounds exhibited strong antitumor promoting activity at the concentration of 2.0 μg/ml when assayed using the inhibition test of Epstein Barr Virus (EBV) activation on Raji cells. At the concentration of 0.4 μg/ml, only nordamnacanthal exhibited strong antitumor promoting activity with the inhibition rate and the cell viability of 75.0% and 75.8%, respectively, which was stronger than the reference compounds genistein and quercetin. In antioxidant assay using ferric thiocyanate (FTC) method, nordamnacanthal and morindone showed stronger antioxidant activity than α-tocopherol. However when the compounds were assayed for scavenging activity of the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, only morindone was considered to be active as free radical scavenger with fifty percent inhibition concentration (IC50) of 40.6 μg/ml. Malaysian Society for Molecular Biology and Biotechnology 2003 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/58528/1/Antitumor%20promoting%20and%20actioxidant%20activities%20of%20anthraquinones%20isolated%20from%20the%20cell%20suspension%20culture%20of%20Morinda%20elliptica.pdf Jasril, and Lajis, Md. Nordin and Lim, Yang Mooi and Abdullah, Mohd Azmuddin and Sukari, Mohd Aspollah and Ali, Abdul Manaf (2003) Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica. Asia Pacific Journal of Molecular Biology and Biotechnology, 11 (1). pp. 3-7. ISSN 0128-7451 http://www.msmbb.org.my/apjmbb/html111/111.htm |
| spellingShingle | Jasril, Lajis, Md. Nordin Lim, Yang Mooi Abdullah, Mohd Azmuddin Sukari, Mohd Aspollah Ali, Abdul Manaf Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica |
| title | Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica |
| title_full | Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica |
| title_fullStr | Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica |
| title_full_unstemmed | Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica |
| title_short | Antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of Morinda elliptica |
| title_sort | antitumor promoting and actioxidant activities of anthraquinones isolated from the cell suspension culture of morinda elliptica |
| url | http://psasir.upm.edu.my/id/eprint/58528/ http://psasir.upm.edu.my/id/eprint/58528/ http://psasir.upm.edu.my/id/eprint/58528/1/Antitumor%20promoting%20and%20actioxidant%20activities%20of%20anthraquinones%20isolated%20from%20the%20cell%20suspension%20culture%20of%20Morinda%20elliptica.pdf |