A brief review on free light chain assays: from conventional to current
Free light chains (FLCs) are tumour markers of monoclonal gammopathies. Detection of urinary FLC or also known as Bence-Jones protein through urinary protein and its immunofixation electrophoreses (UPE and uIFE, respectively) have been considered the gold standard for its biochemical diagnosis. This...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2017
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/58284/ http://psasir.upm.edu.my/id/eprint/58284/1/2017082916081207_MJMHS_Vol13_No2_2017_-_0027_-_6th_proof.pdf |
| _version_ | 1848853603619438592 |
|---|---|
| author | Zahari Sham, Siti Yazmin Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna |
| author_facet | Zahari Sham, Siti Yazmin Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna |
| author_sort | Zahari Sham, Siti Yazmin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Free light chains (FLCs) are tumour markers of monoclonal gammopathies. Detection of urinary FLC or also known as Bence-Jones protein through urinary protein and its immunofixation electrophoreses (UPE and uIFE, respectively) have been considered the gold standard for its biochemical diagnosis. This is mainly due to their superior detection limits compared to their counterpart investigations in serum. However, urinalysis is limited in many ways. The emergence of serum FLC assay with markedly improved detection limit circumvents many of these problems and has gained much importance in biochemical investigations of monoclonal gammopathies. Nevertheless, they are not without limitations. This review discusses the advantages and limitations of serum and urinary FLC assays. |
| first_indexed | 2025-11-15T10:56:36Z |
| format | Article |
| id | upm-58284 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:56:36Z |
| publishDate | 2017 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-582842018-01-26T09:47:22Z http://psasir.upm.edu.my/id/eprint/58284/ A brief review on free light chain assays: from conventional to current Zahari Sham, Siti Yazmin Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Free light chains (FLCs) are tumour markers of monoclonal gammopathies. Detection of urinary FLC or also known as Bence-Jones protein through urinary protein and its immunofixation electrophoreses (UPE and uIFE, respectively) have been considered the gold standard for its biochemical diagnosis. This is mainly due to their superior detection limits compared to their counterpart investigations in serum. However, urinalysis is limited in many ways. The emergence of serum FLC assay with markedly improved detection limit circumvents many of these problems and has gained much importance in biochemical investigations of monoclonal gammopathies. Nevertheless, they are not without limitations. This review discusses the advantages and limitations of serum and urinary FLC assays. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2017 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/58284/1/2017082916081207_MJMHS_Vol13_No2_2017_-_0027_-_6th_proof.pdf Zahari Sham, Siti Yazmin and Chellappah Thambiah, Subashini and Samsudin, Intan Nureslyna (2017) A brief review on free light chain assays: from conventional to current. Malaysian Journal of Medicine and Health Sciences, 13 (2). pp. 59-62. ISSN 1675-8544 http://www.medic.upm.edu.my/upload/dokumen/2017082916081207_MJMHS_Vol13_No2_2017_-_0027_-_6th_proof.pdf |
| spellingShingle | Zahari Sham, Siti Yazmin Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna A brief review on free light chain assays: from conventional to current |
| title | A brief review on free light chain assays: from conventional to current |
| title_full | A brief review on free light chain assays: from conventional to current |
| title_fullStr | A brief review on free light chain assays: from conventional to current |
| title_full_unstemmed | A brief review on free light chain assays: from conventional to current |
| title_short | A brief review on free light chain assays: from conventional to current |
| title_sort | brief review on free light chain assays: from conventional to current |
| url | http://psasir.upm.edu.my/id/eprint/58284/ http://psasir.upm.edu.my/id/eprint/58284/ http://psasir.upm.edu.my/id/eprint/58284/1/2017082916081207_MJMHS_Vol13_No2_2017_-_0027_-_6th_proof.pdf |