Synthesis and characterization of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate and benzyl N-[1-(thiophen-3-yl)ethylidene] hydrazine carbodithioate and the X-ray crystal structure of bis{benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate}nickel(II)

Synthesis and characterization of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate and benzyl N-[1-(thiophen-3-yl)ethylidene] hydrazine carbodithioate and the X-ray crystal structure of bis{benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate}nickel(II)

Two bidentate Schiff bases have been synthesized by reaction of S-benzyldithiocarbazate with 2-acetylthiophene and 3-acetylthiophene to give benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate (SB2ATP) and benzyl N-[1-(thiophen-3-yl)ethylidene]hydrazine carbodithioate (SB3ATP). The SB2AT...

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Main Authors: Chan, Eddy Mun Hoe, Crouse, Karen Anne, Mohamed Tahir, Mohamed Ibrahim, Rosli, Rozita, Umar-Tsafe, Nasir, Cowley, Andrew R.
Format: Article
Language:English
English
Published: Elsevier 2008
Online Access:http://psasir.upm.edu.my/id/eprint/5825/
http://psasir.upm.edu.my/id/eprint/5825/1/Synthesis%20and%20characterization%20of%20cobalt.pdf
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author Chan, Eddy Mun Hoe
Crouse, Karen Anne
Mohamed Tahir, Mohamed Ibrahim
Rosli, Rozita
Umar-Tsafe, Nasir
Cowley, Andrew R.
author_facet Chan, Eddy Mun Hoe
Crouse, Karen Anne
Mohamed Tahir, Mohamed Ibrahim
Rosli, Rozita
Umar-Tsafe, Nasir
Cowley, Andrew R.
author_sort Chan, Eddy Mun Hoe
building UPM Institutional Repository
collection Online Access
description Two bidentate Schiff bases have been synthesized by reaction of S-benzyldithiocarbazate with 2-acetylthiophene and 3-acetylthiophene to give benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate (SB2ATP) and benzyl N-[1-(thiophen-3-yl)ethylidene]hydrazine carbodithioate (SB3ATP). The SB2ATP and SB3ATP were then reacted with five metal ions, cobalt(II), nickel(II), copper(II),zinc(II) and cadmium (II) to form 10 metal complexes, all of general formula ML2. The compounds synthesized were assayed for their bioactivities against selected pathogens and cancer cells. X-ray crystal structure analysis of Ni(SB2ATP)2 showed it to be a distorted square planar complex. All the compounds are non-electrolytes in DMSO. Cu(SB2ATP)2 showed strong activity towards Candida lypolytica.SB2ATP, SB3ATP, Co(SB2ATP)2, Cd(SB2ATP)2 and Cu(SB3ATP)2 showed weak activity against several microbes and fungi while the others showed no activity toward these targets. SB2ATP and Cd(SB3ATP)2 showed significant bioactivity towards human myeloid leukemia (HL-60) while Co(SB3ATP)2 showed slight cytotoxic activity towards this cell line. SB2ATP, SB3ATP, Co(SB2ATP)2,Cu(SB2ATP)2, Cu(SB3ATP)2, Zn(SB2ATP)2 and Cd(SB2ATP)2 showed significant chemotherapeutic activity against human breast carcinoma with positive estrogen receptor (MCF-7) while the remainder of the compounds showed significant bioactivity. The Schiff bases displayed higher cytotoxic activity compared to their metal complexes except for Cu(SB3ATP)2. None of the compounds showed any cytotoxic activity towards human cervical cancer (HeLa) or towards human breast carcinoma with negative estrogen receptors(MDA-MB-231).
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institution Universiti Putra Malaysia
institution_category Local University
language English
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last_indexed 2025-11-15T07:23:40Z
publishDate 2008
publisher Elsevier
recordtype eprints
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spelling upm-58252015-11-24T04:19:24Z http://psasir.upm.edu.my/id/eprint/5825/ Synthesis and characterization of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate and benzyl N-[1-(thiophen-3-yl)ethylidene] hydrazine carbodithioate and the X-ray crystal structure of bis{benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate}nickel(II) Chan, Eddy Mun Hoe Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Rosli, Rozita Umar-Tsafe, Nasir Cowley, Andrew R. Two bidentate Schiff bases have been synthesized by reaction of S-benzyldithiocarbazate with 2-acetylthiophene and 3-acetylthiophene to give benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate (SB2ATP) and benzyl N-[1-(thiophen-3-yl)ethylidene]hydrazine carbodithioate (SB3ATP). The SB2ATP and SB3ATP were then reacted with five metal ions, cobalt(II), nickel(II), copper(II),zinc(II) and cadmium (II) to form 10 metal complexes, all of general formula ML2. The compounds synthesized were assayed for their bioactivities against selected pathogens and cancer cells. X-ray crystal structure analysis of Ni(SB2ATP)2 showed it to be a distorted square planar complex. All the compounds are non-electrolytes in DMSO. Cu(SB2ATP)2 showed strong activity towards Candida lypolytica.SB2ATP, SB3ATP, Co(SB2ATP)2, Cd(SB2ATP)2 and Cu(SB3ATP)2 showed weak activity against several microbes and fungi while the others showed no activity toward these targets. SB2ATP and Cd(SB3ATP)2 showed significant bioactivity towards human myeloid leukemia (HL-60) while Co(SB3ATP)2 showed slight cytotoxic activity towards this cell line. SB2ATP, SB3ATP, Co(SB2ATP)2,Cu(SB2ATP)2, Cu(SB3ATP)2, Zn(SB2ATP)2 and Cd(SB2ATP)2 showed significant chemotherapeutic activity against human breast carcinoma with positive estrogen receptor (MCF-7) while the remainder of the compounds showed significant bioactivity. The Schiff bases displayed higher cytotoxic activity compared to their metal complexes except for Cu(SB3ATP)2. None of the compounds showed any cytotoxic activity towards human cervical cancer (HeLa) or towards human breast carcinoma with negative estrogen receptors(MDA-MB-231). Elsevier 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/5825/1/Synthesis%20and%20characterization%20of%20cobalt.pdf Chan, Eddy Mun Hoe and Crouse, Karen Anne and Mohamed Tahir, Mohamed Ibrahim and Rosli, Rozita and Umar-Tsafe, Nasir and Cowley, Andrew R. (2008) Synthesis and characterization of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate and benzyl N-[1-(thiophen-3-yl)ethylidene] hydrazine carbodithioate and the X-ray crystal structure of bis{benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate}nickel(II). Polyhedron, 27 (4). pp. 1141-1149. ISSN 0277-5387 http://dx.doi.org/10.1016/j.poly.2007.11.035 10.1016/j.poly.2007.11.035 English
spellingShingle Chan, Eddy Mun Hoe
Crouse, Karen Anne
Mohamed Tahir, Mohamed Ibrahim
Rosli, Rozita
Umar-Tsafe, Nasir
Cowley, Andrew R.
Synthesis and characterization of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate and benzyl N-[1-(thiophen-3-yl)ethylidene] hydrazine carbodithioate and the X-ray crystal structure of bis{benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate}nickel(II)
title Synthesis and characterization of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate and benzyl N-[1-(thiophen-3-yl)ethylidene] hydrazine carbodithioate and the X-ray crystal structure of bis{benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate}nickel(II)
title_full Synthesis and characterization of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate and benzyl N-[1-(thiophen-3-yl)ethylidene] hydrazine carbodithioate and the X-ray crystal structure of bis{benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate}nickel(II)
title_fullStr Synthesis and characterization of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate and benzyl N-[1-(thiophen-3-yl)ethylidene] hydrazine carbodithioate and the X-ray crystal structure of bis{benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate}nickel(II)
title_full_unstemmed Synthesis and characterization of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate and benzyl N-[1-(thiophen-3-yl)ethylidene] hydrazine carbodithioate and the X-ray crystal structure of bis{benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate}nickel(II)
title_short Synthesis and characterization of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) complexes of benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate and benzyl N-[1-(thiophen-3-yl)ethylidene] hydrazine carbodithioate and the X-ray crystal structure of bis{benzyl N-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate}nickel(II)
title_sort synthesis and characterization of cobalt(ii), nickel(ii), copper(ii), zinc(ii) and cadmium(ii) complexes of benzyl n-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate and benzyl n-[1-(thiophen-3-yl)ethylidene] hydrazine carbodithioate and the x-ray crystal structure of bis{benzyl n-[1-(thiophen-2-yl)ethylidene] hydrazine carbodithioate}nickel(ii)
url http://psasir.upm.edu.my/id/eprint/5825/
http://psasir.upm.edu.my/id/eprint/5825/
http://psasir.upm.edu.my/id/eprint/5825/
http://psasir.upm.edu.my/id/eprint/5825/1/Synthesis%20and%20characterization%20of%20cobalt.pdf

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