Benzylidene derivatives of andrographolide inhibit
growth of breast and colon cancer cells in vitro by
inducing G1 arrest and apoptosis

QR Code

Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G1 arrest and apoptosis

Background and purpose: Andrographolide, the major phytoconstituent of Andrographis paniculata, was previously shown by us to have activity against breast cancer. This led to synthesis of new andrographolide analogues to find compounds with better activity than the parent compound. Selected benzylid...

Full description

Bibliographic Details
Main Authors:	Jada, Srinivasa Rao, Matthews, Charlie, Saad, Mohd Said, Hamzah, Ahmad Sazali, Lajis, Md Nordin, Stevens, M. F. G., Stanslas, J.
Format:	Article
Language:	English English
Published:	Macmillan Publishers Limited 2008
Online Access:	http://psasir.upm.edu.my/id/eprint/5784/ http://psasir.upm.edu.my/id/eprint/5784/1/Benzylidene%20derivatives%20of%20andrographolide%20inhibit%20growth%20of%20breast%20and%20colon%20cancer%20cells%20in%20vitro%20by%20inducing%20G1%20arrest%20and%20apoptosis.pdf

Similar Items

Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells.
by: Hui, Chyn Wong, et al.
Published: (2011)

NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide
by: Wong, Charng Choon, et al.
Published: (2014)

Semisynthesis and in vitro anticancer activities of andrographolide analogues
by: Jada, Srinivasa Rao, et al.
Published: (2007)

Semisynthesis of Andrographolide Derivatives and Evaluation of Their Antitumour Properties
by: Rao, Jada Srinivasa
Published: (2004)

SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells
by: Wong, Hui Chyn, et al.
Published: (2014)

Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis
by: Manikam, Shiamala Devi, et al.
Published: (2009)

Nordamnacanthal induced apoptosis and mitotic-G2/M arrest with downregulation of Bcl-2 in the human breast cancer cell line (MCF-7).
by: Ishak , Norsyafini, et al.
Published: (2010)

In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog
by: Wong, Charng Choon, et al.
Published: (2014)

Flavokawain Derivative FLS Induced G2/M Arrest and Apoptosis on Breast Cancer MCF-7 Cell Line
by: Norlaily, Mohd Ali, et al.
Published: (2016)

Dillenia suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via induction of G2/M arrest and apoptosis
by: Armania, Nurdin, et al.
Published: (2013)

Synthesis of an Anthraquinone Derivative (DHAQC) and its Effect on Induction of G2/M Arrest and Apoptosis in Breast Cancer MCF-7 Cell Line
by: Swee, Keong Yeap, et al.
Published: (2015)

Synthesis of anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell lines
by: Yeap, Swee Keong, et al.
Published: (2015)

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
by: Hocker, Harrison J., et al.
Published: (2013)

Dicranopteris linearis extract inhibits the proliferation of human breast cancer cell line (MDA-MB-231) via induction of S-phase arrest and apoptosis
by: Baharuddin, Aifaa Akmal, et al.
Published: (2018)

Elucidation of anticancer activity mechanism of 3,19-(2-Bromobenzylidene) andrographolide (SRJ09) in breast and colon cancer cells
by: Wong, Charng Choon
Published: (2016)

Bcl-2 was downregulated in G2/M-arrest breast cancer cells MCF-7-treated with nordamnacanthal
by: Saiful Yazan, Latifah, et al.
Published: (2010)

Induction of apoptosis and G2/M arrest by ampelopsin E from Dryobalanops towards triple negative breast cancer cells, MDA-MB-231
by: Abd Rahman, Napsiah, et al.
Published: (2016)

Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines
by: Shun, Ying Quah, et al.
Published: (2021)

Effect of ximenynic acid on cell cycle arrest and apoptosis and COX-1 in HepG2 cells
by: Cai, F., et al.
Published: (2016)

Andrographolide as a template in the synthesis of new anticancer agents with potentially novel molecular targets
by: Stanslas, Johnson, et al.
Published: (2010)

In vitro growth inhibition, molecular mechanisms of cell cycle arrest, and apoptosis in prostate cancer cells by SRJ23
by: Wong, Hui Chyn
Published: (2013)

Synthetic Curcumin Derivative DK1 Possessed G2/M Arrest and Induced Apoptosis Through Accumulation of Intracellular ROS in MCF-7 Breast Cancer Cells
by: Norlaily, Mohd Ali, et al.
Published: (2017)

Synthetic Curcumin Derivative DK1 Possessed G2M Arrest and Induced Apoptosis Through Accumulation of Intracellular ROS in MCF-7 Breast Cancer Cells
by: Norlaily, Mohd Ali, et al.
Published: (2017)

Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7 breast cancer cells
by: Mohd Ali, Norlaily, et al.
Published: (2017)

A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB activation pathway
by: Abang Ishak, Dayang Hazwani, et al.
Published: (2014)

Zerumbone induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in Jurkat cell line
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G2/M cell cycle arrest
by: Armania, Nurdin, et al.
Published: (2013)

In vitro growth inhibition, caspase-dependent apoptosis, and S and G2/M phase arrest in breast cancer cells induced by fluorine-incorporated gold I compound, Ph3PAu[SC(OMe)=NC6H4F-3]
by: Richard Ming, Chuan Yu, et al.
Published: (2022)

Clausenidin induces caspase-dependent apoptosis in colon cancer
by: Waziri, Peter M., et al.
Published: (2016)

Rice bran phytic acid (IP6) induces growth inhibition, cell cycle arrest and apoptosis on human colorectal adenocarcinoma cells
by: Mohd Esa, Norhaizan, et al.
Published: (2010)

Multi-branched benzylidene ketone based photoinitiators for multiphoton fabrication
by: Zhang, Fan, et al.
Published: (2017)

Cytotoxicity, cell cycle arrest, and apoptosis in breast cancer cell lines exposed to an extract of the seed kernel of Mangifera pajang (bambangan).
by: Abu Bakar, Mohd Fadzelly, et al.
Published: (2010)

Studies on the adsorption and corrosion inhibition of substituted benzylidene Schiff bases on mild steel in 1 M HCl / Nor Zakiah Nor Hashim
by: Nor Hashim, Nor Zakiah
Published: (2016)

Studies on the adsorption and corrosion inhibition of substituted benzylidene schiff bases on mild steel in 1 M HCI / Nor Zakiah Nor Hashim
by: Nor Hashim, Nor Zakiah
Published: (2015)

Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents
by: Soo, Hon Liong, et al.
Published: (2019)

Self-nanoemulsifying delivery of andrographolide: ameliorating islet beta cells and inhibiting adipocyte differentiation
by: Syukri, Yandi, et al.
Published: (2020)

Inhibition of Clostridium scindens and Clostridium hiranonis growth by Bifidobacterium pseudocatenulatum G4 in simulated colonic pH.
by: Babak, Rasti, et al.
Published: (2013)

An investigation of p53’s differential activation of cell cycle arrest and apoptosis
by: Zhang, Yuan
Published: (2008)

Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells
by: Alshwyeh, Hussah Abdullah, et al.
Published: (2024)

Apoptosis and cell cycle arrest of MCF-7R breast carcinoma cells by bis(phosphane)copper(I) thiocarbamides derivative compounds
by: Ooi, Kah Kooi
Published: (2017)