Gastroprotective activity of Spirulina platensis in acetic acid and ethanol induced ulcers in rats
Objective: The effects of gastroprotective properties of Spirulina platensis was investigated in acetic acid and ethanol induced ulcers in rats. Methods: Administration of 2 and 4mg/kg Spirulina platensis extract for 7 days. After day 7, oral administration of either 80% (v/v) ethanol or 6% (v/v) ac...
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| Format: | Article |
| Language: | English |
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Informatics Publishing Limited and Natural Remedies
2007
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| Online Access: | http://psasir.upm.edu.my/id/eprint/56924/ http://psasir.upm.edu.my/id/eprint/56924/1/Gastroprotective%20activity%20of%20Spirulina%20platensis%20in%20acetic%20acid%20and%20ethanol%20induced%20ulcers%20in%20rats.pdf |
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| author | Somchit, M. N. S., Siti Rahmah A., Zuraini A., Ahmad Bustamam Zakaria, Z. A. Somchit, N. Shamsuddin, L. |
| author_facet | Somchit, M. N. S., Siti Rahmah A., Zuraini A., Ahmad Bustamam Zakaria, Z. A. Somchit, N. Shamsuddin, L. |
| author_sort | Somchit, M. N. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objective: The effects of gastroprotective properties of Spirulina platensis was investigated in acetic acid and ethanol induced ulcers in rats. Methods: Administration of 2 and 4mg/kg Spirulina platensis extract for 7 days. After day 7, oral administration of either 80% (v/v) ethanol or 6% (v/v) acetic acid. Control rats received saline or anti-ulcer drug omeprazole (20 mg/kg) prior to ulcer induction. Results: The extract inhibited the mean lesion score of acetic acid, 4.333 to 3.000. Whereas, for ethanol induced ulcers, the extract reduced the lesion scoring from 2.833 to 1.677. However, this activity was statistically less potent than the anti-ulcer drug, omeprazole. Spirulina platensis alone did not induce any ulcers in rats. Conclusions: These results suggested that Spirulina platensis has gastroprotective activity against ulcers induced by acetic acid and ethanol. |
| first_indexed | 2025-11-15T10:50:32Z |
| format | Article |
| id | upm-56924 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:50:32Z |
| publishDate | 2007 |
| publisher | Informatics Publishing Limited and Natural Remedies |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-569242017-09-06T09:18:36Z http://psasir.upm.edu.my/id/eprint/56924/ Gastroprotective activity of Spirulina platensis in acetic acid and ethanol induced ulcers in rats Somchit, M. N. S., Siti Rahmah A., Zuraini A., Ahmad Bustamam Zakaria, Z. A. Somchit, N. Shamsuddin, L. Objective: The effects of gastroprotective properties of Spirulina platensis was investigated in acetic acid and ethanol induced ulcers in rats. Methods: Administration of 2 and 4mg/kg Spirulina platensis extract for 7 days. After day 7, oral administration of either 80% (v/v) ethanol or 6% (v/v) acetic acid. Control rats received saline or anti-ulcer drug omeprazole (20 mg/kg) prior to ulcer induction. Results: The extract inhibited the mean lesion score of acetic acid, 4.333 to 3.000. Whereas, for ethanol induced ulcers, the extract reduced the lesion scoring from 2.833 to 1.677. However, this activity was statistically less potent than the anti-ulcer drug, omeprazole. Spirulina platensis alone did not induce any ulcers in rats. Conclusions: These results suggested that Spirulina platensis has gastroprotective activity against ulcers induced by acetic acid and ethanol. Informatics Publishing Limited and Natural Remedies 2007 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/56924/1/Gastroprotective%20activity%20of%20Spirulina%20platensis%20in%20acetic%20acid%20and%20ethanol%20induced%20ulcers%20in%20rats.pdf Somchit, M. N. and S., Siti Rahmah and A., Zuraini and A., Ahmad Bustamam and Zakaria, Z. A. and Somchit, N. and Shamsuddin, L. (2007) Gastroprotective activity of Spirulina platensis in acetic acid and ethanol induced ulcers in rats. Journal of Natural Remedies, 7 (1). pp. 37-42. ISSN 0972-5547; ESSN: 2320-3358 http://www.informaticsjournals.com/index.php/jnr/article/view/192 |
| spellingShingle | Somchit, M. N. S., Siti Rahmah A., Zuraini A., Ahmad Bustamam Zakaria, Z. A. Somchit, N. Shamsuddin, L. Gastroprotective activity of Spirulina platensis in acetic acid and ethanol induced ulcers in rats |
| title | Gastroprotective activity of Spirulina platensis in acetic acid and ethanol induced ulcers in rats |
| title_full | Gastroprotective activity of Spirulina platensis in acetic acid and ethanol induced ulcers in rats |
| title_fullStr | Gastroprotective activity of Spirulina platensis in acetic acid and ethanol induced ulcers in rats |
| title_full_unstemmed | Gastroprotective activity of Spirulina platensis in acetic acid and ethanol induced ulcers in rats |
| title_short | Gastroprotective activity of Spirulina platensis in acetic acid and ethanol induced ulcers in rats |
| title_sort | gastroprotective activity of spirulina platensis in acetic acid and ethanol induced ulcers in rats |
| url | http://psasir.upm.edu.my/id/eprint/56924/ http://psasir.upm.edu.my/id/eprint/56924/ http://psasir.upm.edu.my/id/eprint/56924/1/Gastroprotective%20activity%20of%20Spirulina%20platensis%20in%20acetic%20acid%20and%20ethanol%20induced%20ulcers%20in%20rats.pdf |