Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes
S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is...
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| Format: | Article |
| Language: | English English |
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Elsevier
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/5690/ http://psasir.upm.edu.my/id/eprint/5690/1/Synthesis.pdf |
| _version_ | 1848840169714614272 |
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| author | How, Fiona Ni Foong Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Tarafder, Md. Tofassa Hossain Cowley, Andrew R. |
| author_facet | How, Fiona Ni Foong Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Tarafder, Md. Tofassa Hossain Cowley, Andrew R. |
| author_sort | How, Fiona Ni Foong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative bidentate ligand. The ligand and its metal complexes have been characterized by a variety of physico-chemical techniques. S-benzyl-b-N-(benzoyl) dithiocarbazate crystallized with Z0 = 2 in its thione form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to C@S, while the
S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond.SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia)while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective activity towards targeted pathogens. |
| first_indexed | 2025-11-15T07:23:04Z |
| format | Article |
| id | upm-5690 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:23:04Z |
| publishDate | 2008 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-56902015-09-17T01:33:10Z http://psasir.upm.edu.my/id/eprint/5690/ Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes How, Fiona Ni Foong Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Tarafder, Md. Tofassa Hossain Cowley, Andrew R. S-Benzyl-b-N-(benzoyl) dithiocarbazate (SBNBODTC) a new disubstituted dithio-carbazate oxygen–sulfur (OS) donor ligand derived from reaction of S-benzyl dithiocarbazate with benzoyl chloride, formed bischelated complexes of general formula [M(OS)2] where M is Cu2+, Ni2+, Cd2+, Co2+ or Pb2+ and OS is a uninegative bidentate ligand. The ligand and its metal complexes have been characterized by a variety of physico-chemical techniques. S-benzyl-b-N-(benzoyl) dithiocarbazate crystallized with Z0 = 2 in its thione form in cis–cis conformation, with the N–N bond adopting a cis geometry with respect to C@S, while the S-benzyl group adopts a cis geometry with respect to the thione sulfur atom across the C–S bond.SBNBODTC, Cu(OS)2, Ni(OS)2 and Pb(OS)2 display marked cytotoxicity against HL-60 (human myeloid leukemia)while Cd(OS)2 and Co(OS)2 are moderately cytotoxic. The compounds showed moderate but selective activity towards targeted pathogens. Elsevier 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/5690/1/Synthesis.pdf How, Fiona Ni Foong and Crouse, Karen Anne and Mohamed Tahir, Mohamed Ibrahim and Tarafder, Md. Tofassa Hossain and Cowley, Andrew R. (2008) Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes. Polyhedron, 27 (15). pp. 3325-3329. ISSN 0277-5387 http://dx.doi.org/10.1016/j.poly.2008.07.022 10.1016/j.poly.2008.07.022 English |
| spellingShingle | How, Fiona Ni Foong Crouse, Karen Anne Mohamed Tahir, Mohamed Ibrahim Tarafder, Md. Tofassa Hossain Cowley, Andrew R. Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes |
| title | Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes |
| title_full | Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes |
| title_fullStr | Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes |
| title_full_unstemmed | Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes |
| title_short | Synthesis, characterization and biological studies of S- benzyl-b-N-(benzoyl)dithiocarbazate and its metal complexes |
| title_sort | synthesis, characterization and biological studies of s- benzyl-b-n-(benzoyl)dithiocarbazate and its metal complexes |
| url | http://psasir.upm.edu.my/id/eprint/5690/ http://psasir.upm.edu.my/id/eprint/5690/ http://psasir.upm.edu.my/id/eprint/5690/ http://psasir.upm.edu.my/id/eprint/5690/1/Synthesis.pdf |