Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract
The efficacy of Tinospora crispa (Menispermaceae) extract for the treatment of diabetes has previously been verified in animal models. In order to substantiate the antidiabetic effect, we characterised the antihyperglycaemic properties by studying its effect on intestinal glucose absorption and gluc...
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| Format: | Article |
| Language: | English |
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Elsevier Science
1998
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| Online Access: | http://psasir.upm.edu.my/id/eprint/56877/ http://psasir.upm.edu.my/id/eprint/56877/1/Pharmacological%20characterisation%20of%20the%20antihyperglycaemic%20properties%20of%20Tinospora%20crispa%20extract.pdf |
| _version_ | 1848853208778145792 |
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| author | Noor, Hamdan Ashcroft, Stephen J. H. |
| author_facet | Noor, Hamdan Ashcroft, Stephen J. H. |
| author_sort | Noor, Hamdan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The efficacy of Tinospora crispa (Menispermaceae) extract for the treatment of diabetes has previously been verified in animal models. In order to substantiate the antidiabetic effect, we characterised the antihyperglycaemic properties by studying its effect on intestinal glucose absorption and glucose uptake into adipocytes. We also performed experiments to characterise in more detail the mechanism of T. crispa-evoked insulin release by challenging it with insulin secretory antagonists viz. adrenaline, somatostatin, verapamil and nifedipine. In addition, we also performed experiments to determine the effect of the extract on cAMP content. The results clearly showed that the antihyperglycaemic effect is not due to interference with intestinal glucose uptake or uptake of the sugar into the peripheral cells. Rather, the antihyperglycaemic effect of T. crispa is probably due to stimulation of insulin release via modulation of β-cell Ca2+concentration. That the insulinotropic effect of T. crispa is physiological suggests that the extract contains compounds which could be purified for use in the treatment of type II diabetes. |
| first_indexed | 2025-11-15T10:50:19Z |
| format | Article |
| id | upm-56877 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:50:19Z |
| publishDate | 1998 |
| publisher | Elsevier Science |
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| spelling | upm-568772017-09-06T07:52:31Z http://psasir.upm.edu.my/id/eprint/56877/ Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract Noor, Hamdan Ashcroft, Stephen J. H. The efficacy of Tinospora crispa (Menispermaceae) extract for the treatment of diabetes has previously been verified in animal models. In order to substantiate the antidiabetic effect, we characterised the antihyperglycaemic properties by studying its effect on intestinal glucose absorption and glucose uptake into adipocytes. We also performed experiments to characterise in more detail the mechanism of T. crispa-evoked insulin release by challenging it with insulin secretory antagonists viz. adrenaline, somatostatin, verapamil and nifedipine. In addition, we also performed experiments to determine the effect of the extract on cAMP content. The results clearly showed that the antihyperglycaemic effect is not due to interference with intestinal glucose uptake or uptake of the sugar into the peripheral cells. Rather, the antihyperglycaemic effect of T. crispa is probably due to stimulation of insulin release via modulation of β-cell Ca2+concentration. That the insulinotropic effect of T. crispa is physiological suggests that the extract contains compounds which could be purified for use in the treatment of type II diabetes. Elsevier Science 1998 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/56877/1/Pharmacological%20characterisation%20of%20the%20antihyperglycaemic%20properties%20of%20Tinospora%20crispa%20extract.pdf Noor, Hamdan and Ashcroft, Stephen J. H. (1998) Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract. Journal of Ethnopharmacology, 62 (1). pp. 7-13. ISSN 0378-8741; ESSN: 1872-7573 http://www.sciencedirect.com/science/article/pii/S0378874198000087?via%3Dihub#! 10.1016/S0378-8741(98)00008-7 |
| spellingShingle | Noor, Hamdan Ashcroft, Stephen J. H. Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract |
| title | Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract |
| title_full | Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract |
| title_fullStr | Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract |
| title_full_unstemmed | Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract |
| title_short | Pharmacological characterisation of the antihyperglycaemic properties of Tinospora crispa extract |
| title_sort | pharmacological characterisation of the antihyperglycaemic properties of tinospora crispa extract |
| url | http://psasir.upm.edu.my/id/eprint/56877/ http://psasir.upm.edu.my/id/eprint/56877/ http://psasir.upm.edu.my/id/eprint/56877/ http://psasir.upm.edu.my/id/eprint/56877/1/Pharmacological%20characterisation%20of%20the%20antihyperglycaemic%20properties%20of%20Tinospora%20crispa%20extract.pdf |