Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach
Inter-individual variability is one of the major challenge in closed-loop control of anaesthesia. This variability could lead to stability problem and must be taken into account during the evaluation of controller. While studies have suggested that variability in nonlinear pharmacodynamics (PD) mode...
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| Format: | Conference or Workshop Item |
| Language: | English |
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IEEE
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/55926/ http://psasir.upm.edu.my/id/eprint/55926/1/Stability%20analysis%20of%20closed-loop%20anaesthesia%20system%20with%20nonlinear%20uncertainty%20a%20circle%20criterion%20approach.pdf |
| _version_ | 1848852938543333376 |
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| author | Chang, Jing Jing Syam, Syafiie |
| author_facet | Chang, Jing Jing Syam, Syafiie |
| author_sort | Chang, Jing Jing |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Inter-individual variability is one of the major challenge in closed-loop control of anaesthesia. This variability could lead to stability problem and must be taken into account during the evaluation of controller. While studies have suggested that variability in nonlinear pharmacodynamics (PD) model is much higher than the linear pharmacokinetic (PK) model, most of the robust stability analyses have only considered uncertainty that exists linearly. In this study, robust stability analysis of a closed-loop anaesthesia control system on uncertainty in nonlinearity was performed. The closed-loop control system consists of a PKPD model and a PID controller that was treated as a Lur'e problem. Circle criterion was applied to determine the bound of nonlinearity that guarantees asymptotic stability of the system. Result shows that the stability bound of the controller is sufficiently large for the possible inter-variability in non-linearity among patients. |
| first_indexed | 2025-11-15T10:46:02Z |
| format | Conference or Workshop Item |
| id | upm-55926 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:46:02Z |
| publishDate | 2016 |
| publisher | IEEE |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-559262017-06-30T09:54:46Z http://psasir.upm.edu.my/id/eprint/55926/ Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach Chang, Jing Jing Syam, Syafiie Inter-individual variability is one of the major challenge in closed-loop control of anaesthesia. This variability could lead to stability problem and must be taken into account during the evaluation of controller. While studies have suggested that variability in nonlinear pharmacodynamics (PD) model is much higher than the linear pharmacokinetic (PK) model, most of the robust stability analyses have only considered uncertainty that exists linearly. In this study, robust stability analysis of a closed-loop anaesthesia control system on uncertainty in nonlinearity was performed. The closed-loop control system consists of a PKPD model and a PID controller that was treated as a Lur'e problem. Circle criterion was applied to determine the bound of nonlinearity that guarantees asymptotic stability of the system. Result shows that the stability bound of the controller is sufficiently large for the possible inter-variability in non-linearity among patients. IEEE 2016 Conference or Workshop Item PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/55926/1/Stability%20analysis%20of%20closed-loop%20anaesthesia%20system%20with%20nonlinear%20uncertainty%20a%20circle%20criterion%20approach.pdf Chang, Jing Jing and Syam, Syafiie (2016) Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach. In: 2016 IEEE-EMBS Conference on Biomedical Engineering and Sciences (IECBES), 4-8 Dec. 2016, Kuala Lumpur, Malaysia. (pp. 664-668). 10.1109/IECBES.2016.7843533 |
| spellingShingle | Chang, Jing Jing Syam, Syafiie Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach |
| title | Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach |
| title_full | Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach |
| title_fullStr | Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach |
| title_full_unstemmed | Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach |
| title_short | Stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach |
| title_sort | stability analysis of closed-loop anaesthesia system with nonlinear uncertainty: a circle criterion approach |
| url | http://psasir.upm.edu.my/id/eprint/55926/ http://psasir.upm.edu.my/id/eprint/55926/ http://psasir.upm.edu.my/id/eprint/55926/1/Stability%20analysis%20of%20closed-loop%20anaesthesia%20system%20with%20nonlinear%20uncertainty%20a%20circle%20criterion%20approach.pdf |