Silicon nanowire interface circuit for DNA detection
Detection and quantification of DNA is critical to many areas of life sciences and health care, from disease diagnosis to drug screening. The transduction of DNA through electrochemical methods have a fast response rate and with a conductometric device like the silicon nanowire which can be fabricat...
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia Press
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/55881/ http://psasir.upm.edu.my/id/eprint/55881/1/29-JTS%28S%29-0143-2016-4thProof.pdf |
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| author | Usman, Kamilu Iman Hamidon, Mohd Nizar Abd Rahman, Siti Fatimah Sim, Guan Ling |
| author_facet | Usman, Kamilu Iman Hamidon, Mohd Nizar Abd Rahman, Siti Fatimah Sim, Guan Ling |
| author_sort | Usman, Kamilu Iman |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Detection and quantification of DNA is critical to many areas of life sciences and health care, from disease diagnosis to drug screening. The transduction of DNA through electrochemical methods have a fast response rate and with a conductometric device like the silicon nanowire which can be fabricated to have a similar diameter of the DNA molecule being targeted, detection is real-time. Critical to this is the interfacing of a current-source and an amplifier capable of achieving a maximum of 10 pico ampere input bias. In this project, we fabricated a silicon nanowire using the top down approach and built a circuit that can mimic the output signal as low as 12 nA and achieved a gain of 1 million to be interfaced with the nanowire for real-time DNA detection. |
| first_indexed | 2025-11-15T10:45:50Z |
| format | Article |
| id | upm-55881 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:45:50Z |
| publishDate | 2017 |
| publisher | Universiti Putra Malaysia Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-558812017-07-05T03:35:12Z http://psasir.upm.edu.my/id/eprint/55881/ Silicon nanowire interface circuit for DNA detection Usman, Kamilu Iman Hamidon, Mohd Nizar Abd Rahman, Siti Fatimah Sim, Guan Ling Detection and quantification of DNA is critical to many areas of life sciences and health care, from disease diagnosis to drug screening. The transduction of DNA through electrochemical methods have a fast response rate and with a conductometric device like the silicon nanowire which can be fabricated to have a similar diameter of the DNA molecule being targeted, detection is real-time. Critical to this is the interfacing of a current-source and an amplifier capable of achieving a maximum of 10 pico ampere input bias. In this project, we fabricated a silicon nanowire using the top down approach and built a circuit that can mimic the output signal as low as 12 nA and achieved a gain of 1 million to be interfaced with the nanowire for real-time DNA detection. Universiti Putra Malaysia Press 2017 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/55881/1/29-JTS%28S%29-0143-2016-4thProof.pdf Usman, Kamilu Iman and Hamidon, Mohd Nizar and Abd Rahman, Siti Fatimah and Sim, Guan Ling (2017) Silicon nanowire interface circuit for DNA detection. Pertanika Journal of Science & Technology, 25 (spec. Feb.). pp. 251-258. ISSN 0128-7680; ESSN: 2231-8526 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2025%20(S)%20Feb.%202017/29-JTS(S)-0143-2016-4thProof.pdf |
| spellingShingle | Usman, Kamilu Iman Hamidon, Mohd Nizar Abd Rahman, Siti Fatimah Sim, Guan Ling Silicon nanowire interface circuit for DNA detection |
| title | Silicon nanowire interface circuit for DNA detection |
| title_full | Silicon nanowire interface circuit for DNA detection |
| title_fullStr | Silicon nanowire interface circuit for DNA detection |
| title_full_unstemmed | Silicon nanowire interface circuit for DNA detection |
| title_short | Silicon nanowire interface circuit for DNA detection |
| title_sort | silicon nanowire interface circuit for dna detection |
| url | http://psasir.upm.edu.my/id/eprint/55881/ http://psasir.upm.edu.my/id/eprint/55881/ http://psasir.upm.edu.my/id/eprint/55881/1/29-JTS%28S%29-0143-2016-4thProof.pdf |