Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line
Our current interest in searching for natural anti-cancer lead compounds from plants has led us to the discovery that the stem and roots of Garcinia mangostana can be a source of such compounds. The stem furnished 2,8-dihydroxy-6-methoxy-5-(3-methylbut-2-enyl)-xanthone (1), which is a new xanthone....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
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Taylor & Francis
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/5572/ http://psasir.upm.edu.my/id/eprint/5572/1/Garcinia%20mangostana.pdf |
| _version_ | 1848840136845950976 |
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| author | Ee, Gwendoline Cheng Lian Daud, Shaari Izzaddin, Sheikh Ahmad Rahmani, Mawardi |
| author_facet | Ee, Gwendoline Cheng Lian Daud, Shaari Izzaddin, Sheikh Ahmad Rahmani, Mawardi |
| author_sort | Ee, Gwendoline Cheng Lian |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Our current interest in searching for natural anti-cancer lead compounds from plants has led us to the discovery that the stem and roots of Garcinia mangostana can be a source of such compounds. The stem furnished 2,8-dihydroxy-6-methoxy-5-(3-methylbut-2-enyl)-xanthone (1), which is a new xanthone. Meanwhile, the root bark of the plant furnished six xanthones, namely -mangostin (2), β-mangostin (3), γ-mangostin (4), garcinone D (5), mangostanol (6), and gartanin (7). The hexane and chloroform extracts of the root bark of G. mangostana as well as the hexane extract of the stem bark were found to be active against the CEM-SS cell line. γ-Mangostin (4) showed good activity with a very low IC50 value of 4.7 μg/ml, while -mangostin (2), mangostanol (6), and garcinone D (5) showed significant activities with IC50 values of 5.5, 9.6, and 3.2 μg/ml, respectively. This is the first report on the cytotoxicity of the extracts of the stem and root bark of G. mangostana and of -mangostin, mangostanol, and garcinone D against the CEM-SS cell line. |
| first_indexed | 2025-11-15T07:22:33Z |
| format | Article |
| id | upm-5572 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:22:33Z |
| publishDate | 2008 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-55722015-09-15T01:14:49Z http://psasir.upm.edu.my/id/eprint/5572/ Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line Ee, Gwendoline Cheng Lian Daud, Shaari Izzaddin, Sheikh Ahmad Rahmani, Mawardi Our current interest in searching for natural anti-cancer lead compounds from plants has led us to the discovery that the stem and roots of Garcinia mangostana can be a source of such compounds. The stem furnished 2,8-dihydroxy-6-methoxy-5-(3-methylbut-2-enyl)-xanthone (1), which is a new xanthone. Meanwhile, the root bark of the plant furnished six xanthones, namely -mangostin (2), β-mangostin (3), γ-mangostin (4), garcinone D (5), mangostanol (6), and gartanin (7). The hexane and chloroform extracts of the root bark of G. mangostana as well as the hexane extract of the stem bark were found to be active against the CEM-SS cell line. γ-Mangostin (4) showed good activity with a very low IC50 value of 4.7 μg/ml, while -mangostin (2), mangostanol (6), and garcinone D (5) showed significant activities with IC50 values of 5.5, 9.6, and 3.2 μg/ml, respectively. This is the first report on the cytotoxicity of the extracts of the stem and root bark of G. mangostana and of -mangostin, mangostanol, and garcinone D against the CEM-SS cell line. Taylor & Francis 2008 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/5572/1/Garcinia%20mangostana.pdf Ee, Gwendoline Cheng Lian and Daud, Shaari and Izzaddin, Sheikh Ahmad and Rahmani, Mawardi (2008) Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line. Journal of Asian Natural Products Research, 10 (5). pp. 475-479. ISSN 1028-6020 http://dx.doi.org/10.1080/10286020801948490 10.1080/10286020801948490 English |
| spellingShingle | Ee, Gwendoline Cheng Lian Daud, Shaari Izzaddin, Sheikh Ahmad Rahmani, Mawardi Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line |
| title | Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line |
| title_full | Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line |
| title_fullStr | Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line |
| title_full_unstemmed | Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line |
| title_short | Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line |
| title_sort | garcinia mangostana: a source of potential anti-cancer lead compounds against cem-ss cell line |
| url | http://psasir.upm.edu.my/id/eprint/5572/ http://psasir.upm.edu.my/id/eprint/5572/ http://psasir.upm.edu.my/id/eprint/5572/ http://psasir.upm.edu.my/id/eprint/5572/1/Garcinia%20mangostana.pdf |