Effects of small molecule inhibitors targeting PI3K, EGFR, IGF-1R, MTOR, SMAD3 and MEK in tube formation and 3-D spheroid assay

QR Code

Effects of small molecule inhibitors targeting PI3K, EGFR, IGF-1R, MTOR, SMAD3 and MEK in tube formation and 3-D spheroid assay

Angiogenesis is the process where new blood capillaries are formed from the preexisting blood vessels. The MEK/ERK and PI3K/Akt signaling pathways are involved in the processes that drive cancer progression such as cell motility, metastasis and angiogenesis. The cellular events in angiogenesis which...

Full description

Bibliographic Details
Main Author:	Ng, Chin Tat
Format:	Thesis
Language:	English
Published:	2014
Subjects:	Angiogenesis Inhibitors Angiogenesis Inducing Agents
Online Access:	http://psasir.upm.edu.my/id/eprint/55642/ http://psasir.upm.edu.my/id/eprint/55642/1/FPSK%28m%29%202014%2051RR.pdf

Similar Items

Development of quinone-rich fraction of Ardisia crispa (Thunb.) A.DC roots mitigates rheumatoid arthritis by suppressing angiogenesis, in vitro and in vivo
by: Blin, Joan
Published: (2021)

Pattern Formation by Lateral Inhibition in Physiological and Tumour Angiogenesis
by: Smith, Holly
Published: (2020)

Dynamics of VEGF-A binding at VEGFR2 and NRP1
by: Peach, Chloe J
Published: (2020)

CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma
by: Smith, Stuart J., et al.
Published: (2012)

Androgen dependent mechanisms of pro-angiogenic networks in placental and tumor development
by: Metzler, Veronika M., et al.
Published: (2017)

Differential regulation of blood flow induced neovascularisation and mural cell recruitment by VEGF and angiopoietin signaling
by: Stone, Oliver A., et al.
Published: (2017)

Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer
by: Shrimali, D., et al.
Published: (2013)

The role and regulation of angiogenesis during key stages of ovarian follicle development
by: Nwachukwu, Chinwe Uchechi
Published: (2019)

Effects of disrupting insulin-like growth factor-1 receptor (IGF-1R) signal transduction pathways with inhibitors of IGF-1R, EGFR, PI3K, MEK, and MTOR in breast cancer cell lines
by: Ayub, Ayunadirah
Published: (2014)

Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
by: Peach, Chloe, et al.
Published: (2018)

Pigment epithelium-derived factor as a natural matrix metalloproteinase inhibitor: a comparison with classical matrix metalloproteinase inhibitors used for cancer treatment
by: Alcantara, M., et al.
Published: (2014)

Vitamin D: Metabolism, Molecular Mechanisms, and Mutations to Malignancies
by: Nemazannikova, N., et al.
Published: (2014)

Mechanisms regulating angiogenesis underlie seasonal control of pituitary function
by: Castle-Miller, Jennifer, et al.
Published: (2017)

The potential role of free chitosan in bone trauma and bone cancer management
by: Tan, M., et al.
Published: (2014)

Exploring the potential role of endothelial ZEB1 in developmental and pathological angiogenesis
by: Green, Kathryn
Published: (2025)

Cytochalasin B-induced membrane vesicles convey angiogenic activity of parental cells
by: Gomzikova, Marina, et al.
Published: (2017)

Luteal angiogenesis and its control
by: Woad, Kathryn J., et al.
Published: (2016)

Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt the vascular maturation in infantile haemangioma
by: Ye, Xi, et al.
Published: (2016)

Mathematical analysis of a model for the growth of the bovine corpus luteum.
by: Prokopiou, Sotiris A., et al.
Published: (2014)

Modelling angiogenesis in three dimensions
by: Parsonson, Louis
Published: (2015)

Targeting p110gamma in gastrointestinal cancers: attack on multiple fronts
by: Falasca, Marco, et al.
Published: (2014)

Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer
by: Ko, S., et al.
Published: (2014)

Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response
by: Smith, Stuart J., et al.
Published: (2015)

Investigation of the role of CD24 gene in the progression of colorectal cancer
by: Hakami, Zaki
Published: (2021)

The role of the cysteine-rich domain and netrin-like domain of secreted frizzled-related protein 4 in angiogenesis inhibition in vitro
by: Longman, D., et al.
Published: (2012)

Factors influencing luteal angiogenesis and alternative splicing in the bovine ovary
by: Thompson, Robert F.
Published: (2018)

Identification of genes and pathways regulated by the PRH/HHEX transcription factor in endothelial and lymphatic cells
by: Dahhan, Rania
Published: (2024)

Investigating the role the PI3K pathway plays in ependymoma pathogenesis
by: Estranero, Jasper
Published: (2019)

Glycolytic control of adjuvant-induced macrophage survival: Role of PI3K, MEK1/2, and Bcl-2
by: Chang, M., et al.
Published: (2009)

Design and synthesis of small molecule inhibitors of coagulation FXIIa
by: Chen, Xi
Published: (2018)

A Potential Effect of Cordycepin on the Feedback between Polyadenylation and PI3K/Akt/mTOR Signalling
by: Lawrence, Steven
Published: (2023)

In vivo pharmacological evaluation of a novel dual-target inhibitor and methylprednisolone as Alzheimer’s disease treatments
by: Zhang, Bocheng
Published: (2023)

PI3K/Akt/mTOR pathway dual inhibitor BEZ235 suppresses the stemness of colon cancer stem cells
by: Chen, J., et al.
Published: (2015)

Scattering from Diatomic Molecules in the Spheroidal Convergent Close-Coupling Formalism
by: Savage, Jeremy Stephen
Published: (2018)

Molecular cloning, functional assessment and transcriptome characterization of cysteine protease inhibitor and kunitz trypsin inhibitor from turmeric (Curcuma longa L.)
by: Chan, Seow Neng
Published: (2016)

Nanocomposites of iron oxide, sodium alginate, and eugenol induce apoptosis via PI3K/Akt/mTOR signaling in Hep3 cells and in vivo hepatotoxicity in the zebrafish model
by: Elderdery, Abozer Y., et al.
Published: (2024)

Effects of albumin–chlorogenic acid nanoparticles on apoptosis and PI3K/Akt/mTOR pathway inhibitory activity in MDA-MB-435s cells
by: Alzahrani, Badr, et al.
Published: (2023)

3D spheroid models for in vitro evaluation of nanoparticles for cancer therapy
by: Tchoryk, Aleksandra
Published: (2018)

Elucidation of basic mechanisms of flavokawin B inhibitory effects on the growth of selected cancer and transformed normal cell lines
by: Umar, Nasir Tsafe
Published: (2008)

Identification of lipase inhibitor from orthosiphon stamineus benth and analysis of lipase-inhibitor complex interaction
by: Alias, Norsyuhada
Published: (2016)