Protective effect following intranasal exposure of goats to live Pasteurella multocida B:2
This study aimed to determine the effect of intranasal exposure to low doses of Pasteurella multocida B:2 on survival of goats challenged with high doses of the same organism. Eighteen goats were selected and divided into three groups. Goats of group 1 were exposed intranasally twice, with a two-wee...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Springer Science + Business Media B.V. 2007
2006
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| Online Access: | http://psasir.upm.edu.my/id/eprint/5555/ |
| _version_ | 1848840131539107840 |
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| author | Saad, Mohd Zamri Ali, Ernie Zuraida Mohd Yusoff, Md Sabri |
| author_facet | Saad, Mohd Zamri Ali, Ernie Zuraida Mohd Yusoff, Md Sabri |
| author_sort | Saad, Mohd Zamri |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study aimed to determine the effect of intranasal exposure to low doses of Pasteurella multocida B:2 on survival of goats challenged with high doses of the same organism. Eighteen goats were selected and divided into three groups. Goats of group 1 were exposed intranasally twice, with a two-week interval, to 7 × 106 cfu/ml of live P. multocida B:2. Goats of group 2 were not exposed to P. multocida B:2 but were kept together with the exposed group 1. Goats of group 3 remained as unexposed controls and were kept separated from the other two groups. Serum samples
were collected at weekly intervals to determine the antibody
levels. At week 5 post exposure, all goats were challenged subcutaneously with 3.7 × 1010 cfu/ml of live P. multocida B:2. Following challenge exposure, 8 (67%) goats (4 goats from each of groups 1 and 2) were killed owing to haemorrhagic septicaemia. Four goats were killed peracutely within 48 h post challenge, while the other four goats were killed acutely between 2 and 4 days post challenge. None of the goats of group 3 were killed for haemorrhagic septicaemia. Goats of groups 1 and 2 showed significantly (p < 0.05) higher antibody levels following the first intranasal exposure to P. multocida B:2. However, only group 1 retained the significantly (p < 0.05) high antibody levels following a second intranasal exposure, and remained significantly (p < 0.05) higher than groups 2 and 3 at the time of challenge. P. multocida B:2 was successfully isolated from various organs of goats that were killed between 1 and 4 days post challenge. |
| first_indexed | 2025-11-15T07:22:28Z |
| format | Article |
| id | upm-5555 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:22:28Z |
| publishDate | 2006 |
| publisher | Springer Science + Business Media B.V. 2007 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-55552010-07-30T04:26:26Z http://psasir.upm.edu.my/id/eprint/5555/ Protective effect following intranasal exposure of goats to live Pasteurella multocida B:2 Saad, Mohd Zamri Ali, Ernie Zuraida Mohd Yusoff, Md Sabri This study aimed to determine the effect of intranasal exposure to low doses of Pasteurella multocida B:2 on survival of goats challenged with high doses of the same organism. Eighteen goats were selected and divided into three groups. Goats of group 1 were exposed intranasally twice, with a two-week interval, to 7 × 106 cfu/ml of live P. multocida B:2. Goats of group 2 were not exposed to P. multocida B:2 but were kept together with the exposed group 1. Goats of group 3 remained as unexposed controls and were kept separated from the other two groups. Serum samples were collected at weekly intervals to determine the antibody levels. At week 5 post exposure, all goats were challenged subcutaneously with 3.7 × 1010 cfu/ml of live P. multocida B:2. Following challenge exposure, 8 (67%) goats (4 goats from each of groups 1 and 2) were killed owing to haemorrhagic septicaemia. Four goats were killed peracutely within 48 h post challenge, while the other four goats were killed acutely between 2 and 4 days post challenge. None of the goats of group 3 were killed for haemorrhagic septicaemia. Goats of groups 1 and 2 showed significantly (p < 0.05) higher antibody levels following the first intranasal exposure to P. multocida B:2. However, only group 1 retained the significantly (p < 0.05) high antibody levels following a second intranasal exposure, and remained significantly (p < 0.05) higher than groups 2 and 3 at the time of challenge. P. multocida B:2 was successfully isolated from various organs of goats that were killed between 1 and 4 days post challenge. Springer Science + Business Media B.V. 2007 2006-11-18 Article PeerReviewed Saad, Mohd Zamri and Ali, Ernie Zuraida and Mohd Yusoff, Md Sabri (2006) Protective effect following intranasal exposure of goats to live Pasteurella multocida B:2. Tropical Animal Health and Production, 38 (7-8). pp. 541-546. ISSN 0049-4747 http://dx.doi.org/10.1007/s11250-006-4437-x 10.1007/s11250-006-4437-x English |
| spellingShingle | Saad, Mohd Zamri Ali, Ernie Zuraida Mohd Yusoff, Md Sabri Protective effect following intranasal exposure of goats to live Pasteurella multocida B:2 |
| title | Protective effect following intranasal exposure of goats
to live Pasteurella multocida B:2 |
| title_full | Protective effect following intranasal exposure of goats
to live Pasteurella multocida B:2 |
| title_fullStr | Protective effect following intranasal exposure of goats
to live Pasteurella multocida B:2 |
| title_full_unstemmed | Protective effect following intranasal exposure of goats
to live Pasteurella multocida B:2 |
| title_short | Protective effect following intranasal exposure of goats
to live Pasteurella multocida B:2 |
| title_sort | protective effect following intranasal exposure of goats
to live pasteurella multocida b:2 |
| url | http://psasir.upm.edu.my/id/eprint/5555/ http://psasir.upm.edu.my/id/eprint/5555/ http://psasir.upm.edu.my/id/eprint/5555/ |