Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway

QR Code

Clausenidin from Clausena excavata induces apoptosis in hepG2 cells via the mitochondrial pathway

Ethnopharmacological relevance: Clausena excavata Burm.f. is used locally in folk medicine for the treatment of cancer in South East Asia. Aim of the study: To determine the mechanism of action of pure clausenidin crystals in the induction of hepatocellular carcinoma (hepG2) cells apoptosis. Mater...

Full description

Bibliographic Details
Main Authors:	Waziri, Peter M., Abdullah, Rasedee, Swee, Keong Yeap, Omar, Abdul Rahman, Abdul, Ahmad Bustamam, Kassim, Nur Kartinee, Malami, Ibrahim, Karunakaran, Thiruventhan, Imam, Mustapha Umar
Format:	Article
Language:	English
Published:	Elsevier 2016
Online Access:	http://psasir.upm.edu.my/id/eprint/55287/ http://psasir.upm.edu.my/id/eprint/55287/1/Clausenidin%20from%20Clausena%20excavata%20induces%20apoptosis%20in%20hepG2%20cells%20via%20the%20.pdf

Similar Items

Characterization and cytotoxicity of clausenidin from Clausena excavata Burm f. and its effects on cell cycle regulation and apoptosis of liver (hepg2) and colon (ht29) cancer cell lines
by: Waziri, Peter Maitalata
Published: (2017)

Clausenidin induces caspase-dependent apoptosis in colon cancer
by: Waziri, Peter M., et al.
Published: (2016)

Cytotoxic constituents of Clausena excavata
by: Mohd Shariff, Nurul Waznah, et al.
Published: (2011)

Chemical Constituents And Bioactivities Of Clausena Excavata
by: Muhamad Sharif, Nurul Waznah
Published: (2009)

Cytotoxicty of zerumbone against liver cancer cell lines (HepG2) via apoptosis activity
by: Abdul Samad, Nozlena, et al.
Published: (2014)

Anti-inflammatory evidence of Clausena excavata in excision wound-induced rats
by: Albaayit, Shaymaa Fadhel Abbas, et al.
Published: (2016)

Evaluation of antioxidant activity and acute toxicity of Clausena excavata leaves extract
by: Albaayit, Shaymaa Fadhel Abbas, et al.
Published: (2014)

Chemical Constituents and Biological Activity of Clausena Excavata (Rutaceae)
by: Lim, Gin Keat
Published: (2005)

A new cytotoxic carbazole alkaloid from Clausena excavata
by: Yap, Taufiq Yun Hin, et al.
Published: (2007)

Nutrient Composition, Antioxidant Andantiproliferative Properties Of Clausena Excavata Andmurraya Koenigii.
by: Wan Mohamad Zain, Wan Nor I'zzah
Published: (2005)

Analysis of Flavonoids and Essential Oils from Clausena Excavata and Their Medicinal Properties
by: Lim, Lay Sean
Published: (2004)

Prophylactic effects of Clausena excavata Burum. f. leaf extract in ethanol-induced gastric ulcers
by: Albaayit, Shaymaa Fadhel Abbas, et al.
Published: (2016)

Zerumbone Exerts Antiproliferative Activity via Apoptosis on HepG2 Cells
by: Syed Alwi, Sharifah Sakinah, et al.
Published: (2007)

Apoptosis effects of Melastoma malabathricum L. extracts on HepG2 cells

Chemical constituents and biological activities of Clausena excavata and some citrus species (Rutaceae)
by: Peh, Tian Hai
Published: (2001)

Anti- enterococcus faecalis, cytotoxicity, phytotoxicity, and anticancer studies on Clausena excavata Burum. f. (Rutaceae) leaves
by: Albaayit, Shaymaa Fadhel Abbas, et al.
Published: (2021)

Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53
by: Zakaria, Yusmazura, et al.
Published: (2009)

A new cytotoxic carbazole alkaloid isolated from the stem bark of Malaysian Clausena excavata
by: Peh, Tian Hai, et al.
Published: (2013)

Selective cytotoxicity of goniothalamin against hepatoblastoma HepG2 cells.
by: Al-Qubaisi, Mothanna, et al.
Published: (2011)

Effect of ximenynic acid on cell cycle arrest and apoptosis and COX-1 in HepG2 cells
by: Cai, F., et al.
Published: (2016)

Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cellsthrough the intrinsic pathway with involvement of NF-kB signalling andG0/G1 cell cycle arrest : a bioassay-guided approach
by: Arbab, Ismail Adam, et al.
Published: (2013)

Chemical constituents and biological activities of two rutaceous plants : Clausena excavata Burm. and Evodia malayana Ridl.
by: Oktima, Winda
Published: (2013)

Garcinia Dulcis fruit extract induced Cytotoxicity and Apoptosis in HepG2 liver cancer cell line
by: Abu Bakar, Mohd Fadzelly, et al.
Published: (2015)

Regulation of p53-, Bcl-2- and Caspase-dependent Signaling Pathway in Xanthorrhizol-induced Apoptosis of HepG2 Hepatoma Cells
by: Tri Handayani,, et al.
Published: (2007)

Anatomy and histochemistry of structures producing aroma in leaves of Sygyzium aromaticum (L.) Merr. and Clausena excavata Burm. f.
by: Qamaruz Zaman, Faridah, et al.
Published: (2018)

Cytotoxic Effect of Girinimbine on HepG2 Cells
by: Mohan, Suvita Syam
Published: (2011)

Artonin E induces p53-independent g1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cell
by: Etti, Imaobong Christopher, et al.
Published: (2017)

Wound healing and gastroprotective effects of Clausena excavata leaves extract by modulating inflammation and oxidative stress / Shaymaa Fadhel Abbas Albaayit
by: Shaymaa Fadhel , Abbas Albaayit
Published: (2016)

Antioxidant behaviour of carotenoids highly accumulated in HepG2 cells
by: Jaswir, Irwandi, et al.
Published: (2012)

Induction of apoptosis by gluconasturtiin-isothiocyanate (GNST-ITC) in human hepatocarcinoma HepG2 cells and human breast adenocarcinoma MCF-7 cells
by: Arumugam, Asvinidevi, et al.
Published: (2020)

Adverse effects of anti-tuberculosis drugs on HepG2 cell bioenergetics
by: Elmorsy, E., et al.
Published: (2016)

Gamma-tocotrienol alters protein expression of HepG2 cell line
by: Farahani ARS,, et al.
Published: (2008)

Suppression effect of eurycomanone on the growth of HepG2 tumour transplanted in mice
by: Zakaria, Yusmazura
Published: (2011)

Zerumbone induces G2/M cell cycle arrest and apoptosis via mitochondrial pathway in Jurkat cell line
by: Rahman, Heshu Sulaiman, et al.
Published: (2014)

A bismuth diethyldithiocarbamate compound promotes apoptosis in HepG2 carcinoma, cell cycle arrest and inhibits cell invasion through modulation of the NF-κB activation pathway
by: Abang Ishak, Dayang Hazwani, et al.
Published: (2014)

Effects of thymoquinone and thymoquinone-loaded nanostructured lipid carrier on hepatocellular carcinoma cell models, Hep3B and HepG2
by: Haron, Aminah Suhaila
Published: (2017)

Cytotoxicity of Clinacanthus Nutans Extracts on Human Hepatoma (HepG2) Cell Line
by: Hazrulrizawati, Hamid, et al.
Published: (2016)

Role of oxidative stress in antituberculous drugs (individuals and combined) cytotoxicity in HepG2 cells
by: Elmorsy, Ekramy, et al.
Published: (2016)

Vanillin rich fraction regulates LDLR and HMGCR gene expression in HepG2 cells.
by: Ismail, Maznah, et al.
Published: (2010)

Cytotoxic effects of conjugated linoleic acids on human hepatoma cancer cells (HepG2)
by: Melaku, Achenef, et al.
Published: (2012)