Changes in diad sequence distribution by preferential chain scission during the thermal hydrolysis of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)
Polyhydroxyalkanoates (PHAs) are microbial polyesters produced by many types of bacteria as an intracellular energy reserve material under substrate limiting conditions and in the presence of excessive carbon sources.¹ Poly((R)-3-hydroxybutyrate) (PHB), the most commonly used microbial polyester, wa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/55245/ http://psasir.upm.edu.my/id/eprint/55245/1/Changes%20in%20diad%20sequence%20distribution%20by%20preferential%20chain%20scission%20during%20the%20thermal%20.pdf |
| Summary: | Polyhydroxyalkanoates (PHAs) are microbial polyesters produced by many types of bacteria as an intracellular energy reserve material under substrate limiting conditions and in the presence of excessive carbon sources.¹ Poly((R)-3-hydroxybutyrate) (PHB), the most commonly used microbial polyester, was the first member of the PHA family to be discovered, and more than 150 other monomer units have been reported to date.2, 3 Poly((R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate) (PHBHHx) is a copolymer in the PHA family that consists of randomly distributed (R)-3-hydroxybutyrate (HB) and (R)-3-hydroxyhexanoate (HHx) units.⁴ This type of copolymer exhibits improved mechanical properties and processability compared with those of PHB and poly((R)-3-hydroxyvalerate) (PHBV).⁵ PHBHHx copolymers are currently produced on a large scale and have proven to be biocompatible in clinical studies using mouse fibroblasts cells, and rabbit articular cartilage-derived chondrocytes.⁶ PHBHHx is a highly favorable copolymer of the PHB family due to its biodegradability, flexible mechanical properties and good melt processability. |
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