Brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats
Brewers' rice is one of abundant agricultural waste products in the rice industry. The present study is designed to investigate the potential of brewers' rice to inhibit the development of aberrant crypt foci (ACF) in colon of azoxymethane (AOM)-treated rats. The effects on the attenuation...
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| Language: | English |
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Pakistan Journal of Pharmaceutical Sciences
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/55222/ http://psasir.upm.edu.my/id/eprint/55222/1/Brewers%27%20rice%20attenuated%20aberrant%20crypt%20foci%20developing%20in%20colon%20of%20azoxymethane-treated%20rats.pdf |
| _version_ | 1848852746358226944 |
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| author | Tan, Bee Ling Mohd Esa, Norhaizan Ashok Kumar, Pandurangan Hamzah, Hazilawati Karim, Roselina |
| author_facet | Tan, Bee Ling Mohd Esa, Norhaizan Ashok Kumar, Pandurangan Hamzah, Hazilawati Karim, Roselina |
| author_sort | Tan, Bee Ling |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Brewers' rice is one of abundant agricultural waste products in the rice industry. The present study is designed to investigate the potential of brewers' rice to inhibit the development of aberrant crypt foci (ACF) in colon of azoxymethane (AOM)-treated rats. The effects on the attenuation of hepatic toxicity and kidney function enzymes were also evaluated. Male Sprague-Dawley rats were randomly divided into five groups: (G1) normal; (G2) AOM alone; and (G3), (G4), and (G5), which were AOM fed with 10%, 20%, and 40% (w/w) of brewers' rice, respectively. The rats in group 2-5 were injected intraperitoneally with AOM (15 mg/kg body weight) once weekly for two weeks. After 8 weeks of treatment,the total number of ACF/colon and the number of ACF in the distal and middle colon were significantly reduced in all treatment groups compared to G2 (p<0.05). Brewers' rice decreased the number of ACF with dysplastic morphology in a dose-dependent manner. Alkaline phosphatase (ALP) level in G5 was significantly lower compared to the G2 (p<0.05). In conclusion, this study found the potential value of brewers' rice in reducing the risk of cancer susceptibility in colon. |
| first_indexed | 2025-11-15T10:42:58Z |
| format | Article |
| id | upm-55222 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:42:58Z |
| publishDate | 2016 |
| publisher | Pakistan Journal of Pharmaceutical Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-552222017-11-29T10:09:52Z http://psasir.upm.edu.my/id/eprint/55222/ Brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats Tan, Bee Ling Mohd Esa, Norhaizan Ashok Kumar, Pandurangan Hamzah, Hazilawati Karim, Roselina Brewers' rice is one of abundant agricultural waste products in the rice industry. The present study is designed to investigate the potential of brewers' rice to inhibit the development of aberrant crypt foci (ACF) in colon of azoxymethane (AOM)-treated rats. The effects on the attenuation of hepatic toxicity and kidney function enzymes were also evaluated. Male Sprague-Dawley rats were randomly divided into five groups: (G1) normal; (G2) AOM alone; and (G3), (G4), and (G5), which were AOM fed with 10%, 20%, and 40% (w/w) of brewers' rice, respectively. The rats in group 2-5 were injected intraperitoneally with AOM (15 mg/kg body weight) once weekly for two weeks. After 8 weeks of treatment,the total number of ACF/colon and the number of ACF in the distal and middle colon were significantly reduced in all treatment groups compared to G2 (p<0.05). Brewers' rice decreased the number of ACF with dysplastic morphology in a dose-dependent manner. Alkaline phosphatase (ALP) level in G5 was significantly lower compared to the G2 (p<0.05). In conclusion, this study found the potential value of brewers' rice in reducing the risk of cancer susceptibility in colon. Pakistan Journal of Pharmaceutical Sciences 2016-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/55222/1/Brewers%27%20rice%20attenuated%20aberrant%20crypt%20foci%20developing%20in%20colon%20of%20azoxymethane-treated%20rats.pdf Tan, Bee Ling and Mohd Esa, Norhaizan and Ashok Kumar, Pandurangan and Hamzah, Hazilawati and Karim, Roselina (2016) Brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats. Pakistan Journal of Pharmaceutical Sciences, 29 (1). pp. 205-212. ISSN 1011-601X |
| spellingShingle | Tan, Bee Ling Mohd Esa, Norhaizan Ashok Kumar, Pandurangan Hamzah, Hazilawati Karim, Roselina Brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats |
| title | Brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats |
| title_full | Brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats |
| title_fullStr | Brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats |
| title_full_unstemmed | Brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats |
| title_short | Brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats |
| title_sort | brewers' rice attenuated aberrant crypt foci developing in colon of azoxymethane-treated rats |
| url | http://psasir.upm.edu.my/id/eprint/55222/ http://psasir.upm.edu.my/id/eprint/55222/1/Brewers%27%20rice%20attenuated%20aberrant%20crypt%20foci%20developing%20in%20colon%20of%20azoxymethane-treated%20rats.pdf |