Antiviral nanodelivery systems: current trends in acyclovir administration
Poor bioavailability of acyclovir in the treatment of viral infections remains one of the major drug delivery concerns of pharmaceutical manufacturers and researchers. Nanoparticulate systems have been exploited with the aim of improving the current pharmacological limitations of acyclovir administr...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/55096/ http://psasir.upm.edu.my/id/eprint/55096/1/Antiviral%20nanodelivery%20systems%20current%20trends%20in%20acyclovir%20administration.pdf |
| _version_ | 1848852711355711488 |
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| author | Hassan, Haniza Adam, Siti Khadijah Othman, Fauziah Shamsuddin, Ahmad Fuad Basir, Rusliza |
| author_facet | Hassan, Haniza Adam, Siti Khadijah Othman, Fauziah Shamsuddin, Ahmad Fuad Basir, Rusliza |
| author_sort | Hassan, Haniza |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Poor bioavailability of acyclovir in the treatment of viral infections remains one of the major drug delivery concerns of pharmaceutical manufacturers and researchers. Nanoparticulate systems have been exploited with the aim of improving the current pharmacological limitations of acyclovir administration. In fact, nanoparticles do offer many advantages, especially in terms of their physicochemical stability and sustained-release properties. Besides, they are made of biocompatible materials, which are nontoxic to cells. Acyclovir has been a focus since the last decade as one of the low bioavailability drug models loaded in various types of newly synthesized drug delivery vehicles. In this review, compositions and formulations of nanosized acyclovir particles, as well as their stability and pharmacokinetic profile, are discussed in further detail. |
| first_indexed | 2025-11-15T10:42:25Z |
| format | Article |
| id | upm-55096 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:42:25Z |
| publishDate | 2016 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-550962018-01-19T03:04:38Z http://psasir.upm.edu.my/id/eprint/55096/ Antiviral nanodelivery systems: current trends in acyclovir administration Hassan, Haniza Adam, Siti Khadijah Othman, Fauziah Shamsuddin, Ahmad Fuad Basir, Rusliza Poor bioavailability of acyclovir in the treatment of viral infections remains one of the major drug delivery concerns of pharmaceutical manufacturers and researchers. Nanoparticulate systems have been exploited with the aim of improving the current pharmacological limitations of acyclovir administration. In fact, nanoparticles do offer many advantages, especially in terms of their physicochemical stability and sustained-release properties. Besides, they are made of biocompatible materials, which are nontoxic to cells. Acyclovir has been a focus since the last decade as one of the low bioavailability drug models loaded in various types of newly synthesized drug delivery vehicles. In this review, compositions and formulations of nanosized acyclovir particles, as well as their stability and pharmacokinetic profile, are discussed in further detail. Hindawi Publishing Corporation 2016 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/55096/1/Antiviral%20nanodelivery%20systems%20current%20trends%20in%20acyclovir%20administration.pdf Hassan, Haniza and Adam, Siti Khadijah and Othman, Fauziah and Shamsuddin, Ahmad Fuad and Basir, Rusliza (2016) Antiviral nanodelivery systems: current trends in acyclovir administration. Journal of Nanomaterials. art. no. 4591634. pp. 1-8. ISSN 1687-4110; ESSN: 1687-4129 https://www.hindawi.com/journals/JNM/index.html 10.1155/2016/4591634 |
| spellingShingle | Hassan, Haniza Adam, Siti Khadijah Othman, Fauziah Shamsuddin, Ahmad Fuad Basir, Rusliza Antiviral nanodelivery systems: current trends in acyclovir administration |
| title | Antiviral nanodelivery systems: current trends in acyclovir administration |
| title_full | Antiviral nanodelivery systems: current trends in acyclovir administration |
| title_fullStr | Antiviral nanodelivery systems: current trends in acyclovir administration |
| title_full_unstemmed | Antiviral nanodelivery systems: current trends in acyclovir administration |
| title_short | Antiviral nanodelivery systems: current trends in acyclovir administration |
| title_sort | antiviral nanodelivery systems: current trends in acyclovir administration |
| url | http://psasir.upm.edu.my/id/eprint/55096/ http://psasir.upm.edu.my/id/eprint/55096/ http://psasir.upm.edu.my/id/eprint/55096/ http://psasir.upm.edu.my/id/eprint/55096/1/Antiviral%20nanodelivery%20systems%20current%20trends%20in%20acyclovir%20administration.pdf |