Anti-cancer activity of three terminalia species and preliminary phytochemical
This study evaluated anticancer potential of three Terminalia species, Terminalia muelleri, Terminalia bellerica, and Terminalia laxiflora and also their phytochemical content were determined. Anticancer potential of the plant extracts was measured according to MTT assay. The results showed that T....
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| Format: | Article |
| Language: | English |
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University of Jordan
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/55078/ http://psasir.upm.edu.my/id/eprint/55078/1/Anti-cancer%20activity%20of%20three%20terminalia%20species%20and%20preliminary%20phytochemical%20.pdf |
| _version_ | 1848852706368684032 |
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| author | Rashed, Khaled Esa, Norhaizan Ismail, Salmiah |
| author_facet | Rashed, Khaled Esa, Norhaizan Ismail, Salmiah |
| author_sort | Rashed, Khaled |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This study evaluated anticancer potential of three Terminalia species, Terminalia muelleri, Terminalia bellerica, and Terminalia laxiflora and also their phytochemical content were determined. Anticancer potential of the plant extracts was measured according to MTT assay. The results showed that T. muelleri methanolic extract was active against breast cancer cell line with IC50 40 µg/mL. T. bellerica methanolic extract exerted cytotoxic effects only against colon cancer and liver cancer cell lines with IC50 of 50 and 15µg/mL, respectively. While T. laxiflora methanolic extract did not inhibit the proliferation of all cancer cell lines tested. Phytochemical investigation of the three plant species proved the presence of carbohydrates, flavonoids, tannins, and triterpenes. The methanolic extracts of T. muelleri and T. bellerica had a significant anticancer activity and so further phytochemical study to isolate and identify the bioactive molecules responsible for the observed anticancer activity is necessary. |
| first_indexed | 2025-11-15T10:42:20Z |
| format | Article |
| id | upm-55078 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:42:20Z |
| publishDate | 2016 |
| publisher | University of Jordan |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-550782018-08-13T07:55:40Z http://psasir.upm.edu.my/id/eprint/55078/ Anti-cancer activity of three terminalia species and preliminary phytochemical Rashed, Khaled Esa, Norhaizan Ismail, Salmiah This study evaluated anticancer potential of three Terminalia species, Terminalia muelleri, Terminalia bellerica, and Terminalia laxiflora and also their phytochemical content were determined. Anticancer potential of the plant extracts was measured according to MTT assay. The results showed that T. muelleri methanolic extract was active against breast cancer cell line with IC50 40 µg/mL. T. bellerica methanolic extract exerted cytotoxic effects only against colon cancer and liver cancer cell lines with IC50 of 50 and 15µg/mL, respectively. While T. laxiflora methanolic extract did not inhibit the proliferation of all cancer cell lines tested. Phytochemical investigation of the three plant species proved the presence of carbohydrates, flavonoids, tannins, and triterpenes. The methanolic extracts of T. muelleri and T. bellerica had a significant anticancer activity and so further phytochemical study to isolate and identify the bioactive molecules responsible for the observed anticancer activity is necessary. University of Jordan 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/55078/1/Anti-cancer%20activity%20of%20three%20terminalia%20species%20and%20preliminary%20phytochemical%20.pdf Rashed, Khaled and Esa, Norhaizan and Ismail, Salmiah (2016) Anti-cancer activity of three terminalia species and preliminary phytochemical. Jordan Journal of Pharmaceutical Sciences, 9 (3). pp. 175-180. ISSN 1995-7157 |
| spellingShingle | Rashed, Khaled Esa, Norhaizan Ismail, Salmiah Anti-cancer activity of three terminalia species and preliminary phytochemical |
| title | Anti-cancer activity of three terminalia species and preliminary phytochemical |
| title_full | Anti-cancer activity of three terminalia species and preliminary phytochemical |
| title_fullStr | Anti-cancer activity of three terminalia species and preliminary phytochemical |
| title_full_unstemmed | Anti-cancer activity of three terminalia species and preliminary phytochemical |
| title_short | Anti-cancer activity of three terminalia species and preliminary phytochemical |
| title_sort | anti-cancer activity of three terminalia species and preliminary phytochemical |
| url | http://psasir.upm.edu.my/id/eprint/55078/ http://psasir.upm.edu.my/id/eprint/55078/1/Anti-cancer%20activity%20of%20three%20terminalia%20species%20and%20preliminary%20phytochemical%20.pdf |