Angiotensin-I converting enzyme (ACE) inhibitory and anti-hypertensive effect of protein hydrolysate from Actinopyga Iecanora (sea cucumber) in rats
Food protein hydrolysates are known to exhibit angiotensin converting enzyme (ACE) inhibitory properties and can be used as a novel functional food for prevention of hypertension. This study evaluated the ACE inhibitory potentials of Actinopyga lecanora proteolysate (ALP) in vivo. The pre-fed rats w...
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| Format: | Article |
| Language: | English |
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MDPI
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/55065/ http://psasir.upm.edu.my/id/eprint/55065/1/Angiotensin-I%20Converting%20Enzyme%20%28ACE%29%20Inhibitory.pdf |
| _version_ | 1848852703107612672 |
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| author | Vishkaei, Mahdokht Sadegh Ebrahimpour, Afshin Abdul-Hamid, Azizah Ismail, Amin Saari, Nazamid |
| author_facet | Vishkaei, Mahdokht Sadegh Ebrahimpour, Afshin Abdul-Hamid, Azizah Ismail, Amin Saari, Nazamid |
| author_sort | Vishkaei, Mahdokht Sadegh |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Food protein hydrolysates are known to exhibit angiotensin converting enzyme (ACE) inhibitory properties and can be used as a novel functional food for prevention of hypertension. This study evaluated the ACE inhibitory potentials of Actinopyga lecanora proteolysate (ALP) in vivo. The pre-fed rats with ALP at various doses (200, 400, 800 mg/kg body weight) exhibited a significant (p ≤ 0.05) suppression effect after inducing hypertension. To determine the optimum effective dose that will produce maximal reduction in blood pressure, ALP at three doses was fed to the rats after inducing hypertension. The results showed that the 800 mg/kg body weight dose significantly reduced blood pressure without noticeable negative physiological effect. In addition, there were no observable changes in the rats’ heart rate after oral administration of the ALP. It was concluded that Actinopyga lecanora proteolysate could potentially be used for the development of functional foods and nutraceuticals for prevention and treatment of hypertension. |
| first_indexed | 2025-11-15T10:42:17Z |
| format | Article |
| id | upm-55065 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:42:17Z |
| publishDate | 2016 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-550652018-07-13T09:00:13Z http://psasir.upm.edu.my/id/eprint/55065/ Angiotensin-I converting enzyme (ACE) inhibitory and anti-hypertensive effect of protein hydrolysate from Actinopyga Iecanora (sea cucumber) in rats Vishkaei, Mahdokht Sadegh Ebrahimpour, Afshin Abdul-Hamid, Azizah Ismail, Amin Saari, Nazamid Food protein hydrolysates are known to exhibit angiotensin converting enzyme (ACE) inhibitory properties and can be used as a novel functional food for prevention of hypertension. This study evaluated the ACE inhibitory potentials of Actinopyga lecanora proteolysate (ALP) in vivo. The pre-fed rats with ALP at various doses (200, 400, 800 mg/kg body weight) exhibited a significant (p ≤ 0.05) suppression effect after inducing hypertension. To determine the optimum effective dose that will produce maximal reduction in blood pressure, ALP at three doses was fed to the rats after inducing hypertension. The results showed that the 800 mg/kg body weight dose significantly reduced blood pressure without noticeable negative physiological effect. In addition, there were no observable changes in the rats’ heart rate after oral administration of the ALP. It was concluded that Actinopyga lecanora proteolysate could potentially be used for the development of functional foods and nutraceuticals for prevention and treatment of hypertension. MDPI 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/55065/1/Angiotensin-I%20Converting%20Enzyme%20%28ACE%29%20Inhibitory.pdf Vishkaei, Mahdokht Sadegh and Ebrahimpour, Afshin and Abdul-Hamid, Azizah and Ismail, Amin and Saari, Nazamid (2016) Angiotensin-I converting enzyme (ACE) inhibitory and anti-hypertensive effect of protein hydrolysate from Actinopyga Iecanora (sea cucumber) in rats. Marine Drugs, 14 (176). pp. 1-14. ISSN 1660-3397; ESSN:1660-3397 10.3390/md14100176 |
| spellingShingle | Vishkaei, Mahdokht Sadegh Ebrahimpour, Afshin Abdul-Hamid, Azizah Ismail, Amin Saari, Nazamid Angiotensin-I converting enzyme (ACE) inhibitory and anti-hypertensive effect of protein hydrolysate from Actinopyga Iecanora (sea cucumber) in rats |
| title | Angiotensin-I converting enzyme (ACE) inhibitory and anti-hypertensive effect of protein hydrolysate from Actinopyga Iecanora (sea cucumber) in rats |
| title_full | Angiotensin-I converting enzyme (ACE) inhibitory and anti-hypertensive effect of protein hydrolysate from Actinopyga Iecanora (sea cucumber) in rats |
| title_fullStr | Angiotensin-I converting enzyme (ACE) inhibitory and anti-hypertensive effect of protein hydrolysate from Actinopyga Iecanora (sea cucumber) in rats |
| title_full_unstemmed | Angiotensin-I converting enzyme (ACE) inhibitory and anti-hypertensive effect of protein hydrolysate from Actinopyga Iecanora (sea cucumber) in rats |
| title_short | Angiotensin-I converting enzyme (ACE) inhibitory and anti-hypertensive effect of protein hydrolysate from Actinopyga Iecanora (sea cucumber) in rats |
| title_sort | angiotensin-i converting enzyme (ace) inhibitory and anti-hypertensive effect of protein hydrolysate from actinopyga iecanora (sea cucumber) in rats |
| url | http://psasir.upm.edu.my/id/eprint/55065/ http://psasir.upm.edu.my/id/eprint/55065/ http://psasir.upm.edu.my/id/eprint/55065/1/Angiotensin-I%20Converting%20Enzyme%20%28ACE%29%20Inhibitory.pdf |