2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase

QR Code

2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase

In the present study, a series of 2-benzoyl-6-benzylidenecyclohexanone analogs have been synthesized and evaluated for their anti-cholinesterase activity. Among the forty-one analogs, four compounds (38, 39, 40 and 41) have been identified as lead compounds due to their highest inhibition on both AC...

Full description

Bibliographic Details
Main Authors:	Sze, Wei Leong, Abas, Faridah, Kok, Wai Lam, Shaari, Khozirah, Lajis, Nordin
Format:	Article
Language:	English
Published:	Elsevier 2016
Online Access:	http://psasir.upm.edu.my/id/eprint/54802/ http://psasir.upm.edu.my/id/eprint/54802/1/2-Benzoyl-6-benzylidenecyclohexanone%20analogs%20as%20potent%20dual%20inhibitors%20of%20acetylcholinesterase%20and%20butyrylcholinesterase.pdf

Similar Items

Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives
by: Leong, Sze Wei, et al.
Published: (2015)

Hierarchical And Fragment Based Virtual Screening Approaches In The Discovery Of Potent Acetylcholinesterase Inhibitor
by: Muhammad, Erma Fatiha
Published: (2022)

New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights
by: Akhtar, Muhammad Nadim, et al.
Published: (2011)

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
by: Taha, Muhammad, et al.
Published: (2019)

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
by: Taha, Muhammad, et al.
Published: (2019)

Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of Î-Glucuronidase and in silico study
by: Muhammad Taha, et al.
Published: (2021)

Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor
by: Chean, Hui Ng, et al.
Published: (2014)

Hits-to-lead optimization of the natural compound 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX Inhibitor: synthesis, structure-activity relationship (SAR) study and computational assignment
by: Ng, Chean Hui, et al.
Published: (2018)

In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor
by: Leong, Sze Wei, et al.
Published: (2018)

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions
by: Drinkwater, Nyssa, et al.
Published: (2016)

Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice
by: Ong, Hui Ming, et al.
Published: (2016)

Novel 2-benzoyl-6-(2,3- dimethoxybenzylidene)-cyclohexenol confers selectivity toward human MLH1 defective cancer cells through synthetic lethality
by: Song, Dedrick Soon Seng, et al.
Published: (2019)

Leukotriene inhibitor and method for producing the same
by: Shaari, Khozirah, et al.
Published: (2010)

Study on acetylcholinesterase inhibitor derived from Datura metel L. / Hani Shuhaireen Mohamad Hanafiah
by: Hani Shuhaireen , Mohamad Hanafiah
Published: (2017)

Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II)
by: Wang, Jia, et al.
Published: (2018)

Acetylcholinesterase studies as colonic pseudo-obstruction inhibitor on quercitrin from neem leaf extract (Azadirachta indica)
by: Abdul Ghani, Nur Hamizah, et al.
Published: (2023)

The Use of Peptide-Membrane Interactions in the Design of Selective and Potent Sodium Channel Inhibitors
by: Schroeder, C., et al.
Published: (2018)

Design and Synthesis of Chalcone Derivatives as Potent Tyrosinase Inhibitors and Their Structural Activity Relationship
by: Akhtar, Muhammad Nadeem, et al.
Published: (2015)

Hyperchaos in acetylcholinesterase enzyme systems
by: Ibrahim, Gamal, et al.
Published: (1997)

Novel phospholipase A2 inhibitors from python serum are potent peptide antibiotics
by: Samy, R., et al.
Published: (2015)

Dual sampling sigma delta analog to digital converter
by: Mohd Isa, Maryam, et al.
Published: (2012)

Synthesis And Biological Activity Of Benzimidazole Analogs As Sirtuin Enzyme Inhibitors
by: Yeong, Keng Yoon
Published: (2016)

In vitro inhibition of acetylcholinesterase by acephate and methamidophos
by: Mohamad, Rosli
Published: (1990)

Silica Supported Indium Heterogeneous Catalyst In Benzylation And Benzoylation Of Toluene
by: Sek, Kei Lin
Published: (2013)

Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease
by: Batson, Jennifer, et al.
Published: (2017)

Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A
by: Altamimi, Abdul Malek S., et al.
Published: (2018)

Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study
by: Zaman, Khalid, et al.
Published: (2019)

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor
by: Whittaker, Steven R., et al.
Published: (2018)

Conventional Organic Solvents And Ionic Liquid Mediated Synthesis Of New Azomethine Compounds As Potent Cholinesterase Inhibitors
by: M. Abd Razik, Basma
Published: (2016)

Use of the curcumin analog BHMC in the treatment of endothelial dysfunction and related disorders
by: Israf Ali, Daud Ahmad, et al.
Published: (2012)

4-Carbethoxy-1-[4-(N,N-dimethylamino)benzoyl]thiosemicarbazide
by: Bera, H., et al.
Published: (2010)

Antinociceptive activities of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, and its possible mechanisms of action in mice
by: Ong, Hui Ming, et al.
Published: (2021)

Acetylcholinesterase activity measurement and clinical features of delirium
by: Jackson, T.A., et al.
Published: (2017)

Development Of An Inhibitive Acetylcholinesterase-Based Assay For Insecticides
by: Tham, Lik Gin
Published: (2008)

Molecular docking analysis of curcumin analogues as human neutrophil elastase inhibitors
by: Narayanaswamy, Radhakrishnan, et al.
Published: (2014)

The comparison between betaglucuronidase (BG) with plasma butyrylcholinesterase (BChE) as biomarker of low-level organophosphate insecticide among vector control operators / Muhamad Ashraf Rostam
by: Rostam, Muhamad Ashraf
Published: (2012)

Bioassay-guided isolation of a potent platelet-activating factor antagonist alkenylresorcinol from Ardisia elliptica
by: Jalil, Juriyati, et al.
Published: (2004)

Synthesis and optimization of palmitoyl-chitosan nanoparticles as a potent dual antioxidant carrier with hydrophobic and hydrophilic compounds
by: Othman, Nurhanisah
Published: (2022)

Discovery of highly potent and selective phosphatidylinositol 3-kinase-δ inhibitors for the treatment of blood cancers and autoimmune diseases
by: Buzrieda, Anas
Published: (2021)

Acetylcholinesterase from Puntius javanicus for the detection of carbamates and organophosphates
by: Sabullah, Mohd Khalizan, et al.
Published: (2015)