Methanolic extract of Clinacanthus nutans exerts antinociceptive activity via the opioid/nitric oxide-mediated, but cGMP-independent, pathways
The objectives of the present study were to determine the mechanisms of antinociceptive effect of methanol extract of Clinacanthus nutans (Acanthaceae) leaves (MECN) using various animal nociceptive models. The antinociceptive activity of orally administered 10% DMSO, 100 mg/kg acetylsalicylic acid...
| Main Authors: | Abdul Rahim, Mohammad Hafiz, Zakaria, Zainul Amiruddin, Mohd Sani, Mohd Hijaz, Omar, Maizatul Hasyima, Yakob, Yusnita, Singh, Manraj, Cheema, Ching, Siew Mooi, Ahmad, Zuraini, Abdul Kadir, Arifah |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
2016
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/54798/ http://psasir.upm.edu.my/id/eprint/54798/1/Methanolic%20extract%20of%20Clinacanthus%20nutans%20exerts%20antinociceptive%20activity.pdf |
Similar Items
Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway
by: Zakaria, Zainul Amiruddin, et al.
Published: (2019)
by: Zakaria, Zainul Amiruddin, et al.
Published: (2019)
Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways.
by: Perimal, Enoch Kumar, et al.
Published: (2011)
by: Perimal, Enoch Kumar, et al.
Published: (2011)
Antinociceptive activity of methanolic extract of Clinacanthus nutans leaves: possible mechanisms of action involved
by: Zakaria, Zainul Amiruddin, et al.
Published: (2018)
by: Zakaria, Zainul Amiruddin, et al.
Published: (2018)
SFRP4 signalling of apoptosis and angiostasis uses nitric oxide-cGMP-permeability axis of endothelium
by: Saran, U., et al.
Published: (2017)
by: Saran, U., et al.
Published: (2017)
Antinoceptive activity of methanolic extract of Clinacanthus nutans leaves : possible mechanisms of action involved
by: Zakaria, Zainul Amiruddin, et al.
Published: (2018)
by: Zakaria, Zainul Amiruddin, et al.
Published: (2018)
Acute and sub-chronic oral toxicity studies of methanol extract of Clinacanthus nutans in mice
by: Zakaria, Zainul Amiruddin, et al.
Published: (2016)
by: Zakaria, Zainul Amiruddin, et al.
Published: (2016)
Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model
by: Zulazmi, Nurul Atiqah, et al.
Published: (2017)
by: Zulazmi, Nurul Atiqah, et al.
Published: (2017)
The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model
by: Hui, Ming Ong, et al.
Published: (2021)
by: Hui, Ming Ong, et al.
Published: (2021)
Antinociceptive effects and mechanisms of action of Clinacanthus nutans Lindau leaf methanolic and petroleum ether extracts in mice
by: Abdul Rahim, Mohammad Hafiz
Published: (2017)
by: Abdul Rahim, Mohammad Hafiz
Published: (2017)
Development of an optimal xeno-free cGMP growth medium for the culture of corneal stroma-derived mesenchymal stem cells
by: Ekrem, Melis
Published: (2020)
by: Ekrem, Melis
Published: (2020)
Bixa orellana leaf extract suppress histamine-induced endothelial hyperpermeability via the PLC-NO-cGMP signaling cascade
by: Yong, Yoke Keong, et al.
Published: (2015)
by: Yong, Yoke Keong, et al.
Published: (2015)
Clinacanthus nutans aqueous extract exerts anti-allergic activity in preclinical anaphylactic models via alternative IgG pathway
by: Kow, Audrey Siew Foong, et al.
Published: (2023)
by: Kow, Audrey Siew Foong, et al.
Published: (2023)
Src family tyrosine kinase Lyn mediates VWF GPIb-IX induced platelet activation via the cGMP signaling pathway
by: Yin, H., et al.
Published: (2008)
by: Yin, H., et al.
Published: (2008)
Infrared drying of Clinacanthus nutans leaves
by: Abdullah, Sriyana, et al.
Published: (2022)
by: Abdullah, Sriyana, et al.
Published: (2022)
Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of the possible mechanisms
by: Zakaria, Zainul Amiruddin, et al.
Published: (2014)
by: Zakaria, Zainul Amiruddin, et al.
Published: (2014)
A review on anticancer and biochemical properties of Clinacanthus nutans
by: Zakaria, Khairun Najwa, et al.
Published: (2016)
by: Zakaria, Khairun Najwa, et al.
Published: (2016)
A review of anticancer, antitumor, and antioxidant of clinacanthus nutans
by: Zakaria, Khairun Najwa, et al.
Published: (2017)
by: Zakaria, Khairun Najwa, et al.
Published: (2017)
Ultrasonic extraction of Clinacanthus nutans and its antioxidant activity
by: Nik Fatima, Nek Kamarzaman
Published: (2013)
by: Nik Fatima, Nek Kamarzaman
Published: (2013)
Assessing potential for heavy metal phytoremediation in Clinacanthus nutans
by: Mohd Sapri, Nurul Aisyah
Published: (2018)
by: Mohd Sapri, Nurul Aisyah
Published: (2018)
Immunomodulatory and cell cycle regulatory effects of clinacanthus nutans
by: Ghazali, Wan Afiqah Syahirah Wan @ Wan Azmi
Published: (2018)
by: Ghazali, Wan Afiqah Syahirah Wan @ Wan Azmi
Published: (2018)
Clinacanthus nutans: a review of the medicinal uses, pharmacology and phytochemistry
by: Alam, Md Ariful, et al.
Published: (2016)
by: Alam, Md Ariful, et al.
Published: (2016)
Investigation of immunomodulatory effects of phytosterols isolated from Clinacanthus nutans
by: Liew, Crystal Xiao-Qi
Published: (2025)
by: Liew, Crystal Xiao-Qi
Published: (2025)
Belalai gajah (clinacanthus nutans) scientific evidence of cancer prevention
by: Hazrulrizawati, Hamid, et al.
Published: (2020)
by: Hazrulrizawati, Hamid, et al.
Published: (2020)
Isolation and characterization of apoptosis-inducing compounds from Clinacanthus nutans
by: Hazrulrizawati, Abd Hamid
Published: (2014)
by: Hazrulrizawati, Abd Hamid
Published: (2014)
Chemical constituents from the butanol fraction of Clinacanthus nutans leaves
by: Zolkeflee, Nur Khaleeda Zulaikha, et al.
Published: (2022)
by: Zolkeflee, Nur Khaleeda Zulaikha, et al.
Published: (2022)
Influence of fresh and thermoxidized carotino oil on Cyclic Guanosine Monophosphate (cGMP) in erythrocytes from Sprague dawley rats / Mohd Fakharul Zaman Raja Yahya and Athifah Najwani Shahidan
by: Raja Yahya, Mohd Fakharul Zaman, et al.
Published: (2012)
by: Raja Yahya, Mohd Fakharul Zaman, et al.
Published: (2012)
Enhanced antinociceptive effects of mitragynine in combination with morphine via opioid receptors activation
by: Abdul Rahman, Shamima
Published: (2014)
by: Abdul Rahman, Shamima
Published: (2014)
Fabrication of face cream containing enriched fraction of protocatechuic acid from Clinacanthus nutans (C. Nutans) leaves
by: Zamery, Muhammad 'Izzuddin, et al.
Published: (2017)
by: Zamery, Muhammad 'Izzuddin, et al.
Published: (2017)
Pharmacological activities and comprehensive metabolite profiling of Clinacanthus nutans extract and fractions
by: Alam, Md. Ariful, et al.
Published: (2016)
by: Alam, Md. Ariful, et al.
Published: (2016)
Extraction of protocatechuic acid enriched fraction from Clinacanthus nutans leaves
by: Zamery, Muhammad 'Izzuddin, et al.
Published: (2017)
by: Zamery, Muhammad 'Izzuddin, et al.
Published: (2017)
The Effects of Clinacanthus nutans Leaf Extract Towards Tyrosinase and Collagenase Activities
by: Lim, She Yan
Published: (2017)
by: Lim, She Yan
Published: (2017)
A review of therapeutic potentials of Clinacanthus nutans as source for alternative medicines
by: Zainol Haida,, et al.
Published: (2019)
by: Zainol Haida,, et al.
Published: (2019)
Biogenic silver nanoparticles of Clinacanthus nutans as antioxidant with antimicrobial and cytotoxic effects
by: Hock, Ing Chiu, et al.
Published: (2021)
by: Hock, Ing Chiu, et al.
Published: (2021)
Cytotoxic, mutagenic and oral pathogen related antimicrobial properties of clinacanthus nutans
by: Alim, A'attiyyah Ab
Published: (2018)
by: Alim, A'attiyyah Ab
Published: (2018)
Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors
by: Chung, Pui Ping, et al.
Published: (2018)
by: Chung, Pui Ping, et al.
Published: (2018)
Antinociceptive effects of cardamonin in mice: Possible involvement of TRPV1, glutamate and opioid receptors
by: Chung, Pui Ping, et al.
Published: (2018)
by: Chung, Pui Ping, et al.
Published: (2018)
Antidiabetic and antioxidants activities of Clinacanthus
nutans (Burm F.) Lindau leaves extracts
by: Murugesu, Suganya, et al.
Published: (2019)
by: Murugesu, Suganya, et al.
Published: (2019)
Antidiabetic and antioxidants activities of Clinacanthus nutans(Burm F.) Lindau leaves extracts
by: S., Murugesu, et al.
Published: (2019)
by: S., Murugesu, et al.
Published: (2019)
Antidiabetic and antioxidants activities of Clinacanthus nutans (Burm F.) Lindau leaves extracts
by: Murugesu, Suganya, et al.
Published: (2019)
by: Murugesu, Suganya, et al.
Published: (2019)
Cytotoxicity Of Clinacanthus Nutans Methanol-Water Extract On Huh-7 Cell Line
by: Chuah, Jia Jun
Published: (2017)
by: Chuah, Jia Jun
Published: (2017)
Similar Items
-
Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway
by: Zakaria, Zainul Amiruddin, et al.
Published: (2019) -
Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways.
by: Perimal, Enoch Kumar, et al.
Published: (2011) -
Antinociceptive activity of methanolic extract of Clinacanthus nutans leaves: possible mechanisms of action involved
by: Zakaria, Zainul Amiruddin, et al.
Published: (2018) -
SFRP4 signalling of apoptosis and angiostasis uses nitric oxide-cGMP-permeability axis of endothelium
by: Saran, U., et al.
Published: (2017) -
Antinoceptive activity of methanolic extract of Clinacanthus nutans leaves : possible mechanisms of action involved
by: Zakaria, Zainul Amiruddin, et al.
Published: (2018)