Metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults
The association between gut microbiota composition with pathogenesis of metabolic diseases namely obesity and type 2 diabetes are increasingly recognized. The aim of the study was to identify the diversity of gut microbiota phylum and families in the gut of healthy, obese and type 2 diabetes adults...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BioPublisher
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/54794/ http://psasir.upm.edu.my/id/eprint/54794/1/Metagenome.pdf |
| _version_ | 1848852631032692736 |
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| author | Kaliyappan, Roseni Amin Nordin, Syafinaz Mohd Yusof, Barakatun Nisak Sieo, Chin Chin Gan, Han Ming |
| author_facet | Kaliyappan, Roseni Amin Nordin, Syafinaz Mohd Yusof, Barakatun Nisak Sieo, Chin Chin Gan, Han Ming |
| author_sort | Kaliyappan, Roseni |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The association between gut microbiota composition with pathogenesis of metabolic diseases namely obesity and type 2 diabetes are increasingly recognized. The aim of the study was to identify the diversity of gut microbiota phylum and families in the gut of healthy, obese and type 2 diabetes adults with metagenomic approach. Six healthy subjects, five obese subjects and five type 2 diabetes subjects of similar inclusion and exclusion criteria were recruited. The different bacterial phyla and families in the stool sample were analyzed with metagenomic analysis. The median (IQR)% of relative abundance for each phylum and families were analyzed. The obese subjects had higher Bacteroidetes 63.50(21.55)% with lower Firmicutes 27.00(13.55)%, meanwhile, the type 2 diabetes subjects also had higher Bacteroidetes 66.50(39.00)% with lower Firmicutes 27.70(19.35)%. These findings shows that there are differences in the gut microbiota composition in the healthy, obese and type 2 diabetes adults which may influence the development of obesity and type 2 diabetes. |
| first_indexed | 2025-11-15T10:41:08Z |
| format | Article |
| id | upm-54794 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:41:08Z |
| publishDate | 2016 |
| publisher | BioPublisher |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-547942018-04-24T06:34:12Z http://psasir.upm.edu.my/id/eprint/54794/ Metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults Kaliyappan, Roseni Amin Nordin, Syafinaz Mohd Yusof, Barakatun Nisak Sieo, Chin Chin Gan, Han Ming The association between gut microbiota composition with pathogenesis of metabolic diseases namely obesity and type 2 diabetes are increasingly recognized. The aim of the study was to identify the diversity of gut microbiota phylum and families in the gut of healthy, obese and type 2 diabetes adults with metagenomic approach. Six healthy subjects, five obese subjects and five type 2 diabetes subjects of similar inclusion and exclusion criteria were recruited. The different bacterial phyla and families in the stool sample were analyzed with metagenomic analysis. The median (IQR)% of relative abundance for each phylum and families were analyzed. The obese subjects had higher Bacteroidetes 63.50(21.55)% with lower Firmicutes 27.00(13.55)%, meanwhile, the type 2 diabetes subjects also had higher Bacteroidetes 66.50(39.00)% with lower Firmicutes 27.70(19.35)%. These findings shows that there are differences in the gut microbiota composition in the healthy, obese and type 2 diabetes adults which may influence the development of obesity and type 2 diabetes. BioPublisher 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/54794/1/Metagenome.pdf Kaliyappan, Roseni and Amin Nordin, Syafinaz and Mohd Yusof, Barakatun Nisak and Sieo, Chin Chin and Gan, Han Ming (2016) Metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults. Genomics and Applied Biology, 7 (3). pp. 1-10. ISSN 1925-1602 http://biopublisher.ca/index.php/gab/article/html/2083/ 10.5376/gab.2016.07.0003 |
| spellingShingle | Kaliyappan, Roseni Amin Nordin, Syafinaz Mohd Yusof, Barakatun Nisak Sieo, Chin Chin Gan, Han Ming Metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults |
| title | Metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults |
| title_full | Metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults |
| title_fullStr | Metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults |
| title_full_unstemmed | Metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults |
| title_short | Metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults |
| title_sort | metagenome: differences in the gut microbiota among healthy, obese and type 2 diabetes adults |
| url | http://psasir.upm.edu.my/id/eprint/54794/ http://psasir.upm.edu.my/id/eprint/54794/ http://psasir.upm.edu.my/id/eprint/54794/ http://psasir.upm.edu.my/id/eprint/54794/1/Metagenome.pdf |