Metabolic and biochemical changes in streptozotocin inducedobese-diabetic rats treated with Phyllanthus niruri extract
Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabe...
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| Format: | Article |
| Language: | English |
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Elsevier
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/54790/ http://psasir.upm.edu.my/id/eprint/54790/1/Metabolic%20and%20biochemical%20changes%20in%20streptozotocin%20induced%20obese-diabetic%20rats%20treated%20with%20Phyllanthus%20niruri%20extract.pdf |
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| author | Mediani, Ahmed Abas, Faridah M., Maulidiani Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin |
| author_facet | Mediani, Ahmed Abas, Faridah M., Maulidiani Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin |
| author_sort | Mediani, Ahmed |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabetes in Sprague–Dawley rats was achieved by a low dose of streptozotocin (STZ) (25 mg/kg bw). Here, we evaluated the in vivo antidiabetic properties of two concentrations (250 and 500 mg/kg bw) of P. niruri via metabolomics approach. The administration of 500 mg/kg bw of P. niruri extract caused the metabolic disorders of obese diabetic rats to be improved towards the normal state. The extract also clearly decreased the serum glucose level and improved the lipid profile in obese diabetic rats. The results of this study may contribute towards better understanding the molecular mechanism of this medicinal plant in managing diabetes mellitus. |
| first_indexed | 2025-11-15T10:41:08Z |
| format | Article |
| id | upm-54790 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:41:08Z |
| publishDate | 2016 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-547902018-04-24T04:52:18Z http://psasir.upm.edu.my/id/eprint/54790/ Metabolic and biochemical changes in streptozotocin inducedobese-diabetic rats treated with Phyllanthus niruri extract Mediani, Ahmed Abas, Faridah M., Maulidiani Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabetes in Sprague–Dawley rats was achieved by a low dose of streptozotocin (STZ) (25 mg/kg bw). Here, we evaluated the in vivo antidiabetic properties of two concentrations (250 and 500 mg/kg bw) of P. niruri via metabolomics approach. The administration of 500 mg/kg bw of P. niruri extract caused the metabolic disorders of obese diabetic rats to be improved towards the normal state. The extract also clearly decreased the serum glucose level and improved the lipid profile in obese diabetic rats. The results of this study may contribute towards better understanding the molecular mechanism of this medicinal plant in managing diabetes mellitus. Elsevier 2016-09 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/54790/1/Metabolic%20and%20biochemical%20changes%20in%20streptozotocin%20induced%20obese-diabetic%20rats%20treated%20with%20Phyllanthus%20niruri%20extract.pdf Mediani, Ahmed and Abas, Faridah and M., Maulidiani and Khatib, Alfi and Tan, Chin Ping and Ismail, Intan Safinar and Shaari, Khozirah and Ismail, Amin and Lajis, Nordin (2016) Metabolic and biochemical changes in streptozotocin inducedobese-diabetic rats treated with Phyllanthus niruri extract. Journal of Pharmaceutical and Biomedical Analysis, 128. pp. 302-312. ISSN 0731-7085; ESSN: 1873-264X https://www.sciencedirect.com/science/article/pii/S073170851630320X?via%3Dihub 10.1016/j.jpba.2016.06.003 |
| spellingShingle | Mediani, Ahmed Abas, Faridah M., Maulidiani Khatib, Alfi Tan, Chin Ping Ismail, Intan Safinar Shaari, Khozirah Ismail, Amin Lajis, Nordin Metabolic and biochemical changes in streptozotocin inducedobese-diabetic rats treated with Phyllanthus niruri extract |
| title | Metabolic and biochemical changes in streptozotocin inducedobese-diabetic rats treated with Phyllanthus niruri extract |
| title_full | Metabolic and biochemical changes in streptozotocin inducedobese-diabetic rats treated with Phyllanthus niruri extract |
| title_fullStr | Metabolic and biochemical changes in streptozotocin inducedobese-diabetic rats treated with Phyllanthus niruri extract |
| title_full_unstemmed | Metabolic and biochemical changes in streptozotocin inducedobese-diabetic rats treated with Phyllanthus niruri extract |
| title_short | Metabolic and biochemical changes in streptozotocin inducedobese-diabetic rats treated with Phyllanthus niruri extract |
| title_sort | metabolic and biochemical changes in streptozotocin inducedobese-diabetic rats treated with phyllanthus niruri extract |
| url | http://psasir.upm.edu.my/id/eprint/54790/ http://psasir.upm.edu.my/id/eprint/54790/ http://psasir.upm.edu.my/id/eprint/54790/ http://psasir.upm.edu.my/id/eprint/54790/1/Metabolic%20and%20biochemical%20changes%20in%20streptozotocin%20induced%20obese-diabetic%20rats%20treated%20with%20Phyllanthus%20niruri%20extract.pdf |