Graphene oxide-gallic acid nanodelivery system for cancer therapy
Despite the technological advancement in the biomedical science, cancer remains a life-threatening disease. In this study, we designed an anticancer nanodelivery system using graphene oxide (GO) as nanocarrier for an active anticancer agent gallic acid (GA). The successful formation nanocomposite (G...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/54398/ http://psasir.upm.edu.my/id/eprint/54398/1/Graphene%20oxide-gallic%20acid%20nanodelivery%20system%20for%20cancer%20therapy.pdf |
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| author | Dorniani, Dena Saifullah, Bullo Barahuie, Farahnaz Arulselvan, Palanisamy Hussein, Mohd Zobir Fakurazi, Sharida Twyman, Lance J. |
| author_facet | Dorniani, Dena Saifullah, Bullo Barahuie, Farahnaz Arulselvan, Palanisamy Hussein, Mohd Zobir Fakurazi, Sharida Twyman, Lance J. |
| author_sort | Dorniani, Dena |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Despite the technological advancement in the biomedical science, cancer remains a life-threatening disease. In this study, we designed an anticancer nanodelivery system using graphene oxide (GO) as nanocarrier for an active anticancer agent gallic acid (GA). The successful formation nanocomposite (GOGA) was characterized using XRD, FTIR, HRTEM, Raman, and UV/Vis spectroscopy. The release study shows that the release of GA from the designed anticancer nanocomposite (GOGA) occurs in a sustained manner in phosphate-buffered saline (PBS) solution at pH 7.4. In in vitro biological studies, normal fibroblast (3T3) and liver cancer cells (HepG2) were treated with different concentrations of GO, GOGA, and GA for 72 h. The GOGA nanocomposite showed the inhibitory effect to cancer cell growth without affecting normal cell growth. The results of this research are highly encouraging to go further for in vivo studies. |
| first_indexed | 2025-11-15T10:39:36Z |
| format | Article |
| id | upm-54398 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:39:36Z |
| publishDate | 2016 |
| publisher | SpringerOpen |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-543982018-03-15T03:55:18Z http://psasir.upm.edu.my/id/eprint/54398/ Graphene oxide-gallic acid nanodelivery system for cancer therapy Dorniani, Dena Saifullah, Bullo Barahuie, Farahnaz Arulselvan, Palanisamy Hussein, Mohd Zobir Fakurazi, Sharida Twyman, Lance J. Despite the technological advancement in the biomedical science, cancer remains a life-threatening disease. In this study, we designed an anticancer nanodelivery system using graphene oxide (GO) as nanocarrier for an active anticancer agent gallic acid (GA). The successful formation nanocomposite (GOGA) was characterized using XRD, FTIR, HRTEM, Raman, and UV/Vis spectroscopy. The release study shows that the release of GA from the designed anticancer nanocomposite (GOGA) occurs in a sustained manner in phosphate-buffered saline (PBS) solution at pH 7.4. In in vitro biological studies, normal fibroblast (3T3) and liver cancer cells (HepG2) were treated with different concentrations of GO, GOGA, and GA for 72 h. The GOGA nanocomposite showed the inhibitory effect to cancer cell growth without affecting normal cell growth. The results of this research are highly encouraging to go further for in vivo studies. SpringerOpen 2016-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/54398/1/Graphene%20oxide-gallic%20acid%20nanodelivery%20system%20for%20cancer%20therapy.pdf Dorniani, Dena and Saifullah, Bullo and Barahuie, Farahnaz and Arulselvan, Palanisamy and Hussein, Mohd Zobir and Fakurazi, Sharida and Twyman, Lance J. (2016) Graphene oxide-gallic acid nanodelivery system for cancer therapy. Nanoscale Research Letters, 11 (491). pp. 1-9. ISSN 1931-7573; ESSN: 1556-276X https://link.springer.com/article/10.1186/s11671-016-1712-2 Drug delivery systems; Graphene oxide; Gallic acid; Controlled-release; Cytotoxicity 10.1186/s11671-016-1712-2 |
| spellingShingle | Drug delivery systems; Graphene oxide; Gallic acid; Controlled-release; Cytotoxicity Dorniani, Dena Saifullah, Bullo Barahuie, Farahnaz Arulselvan, Palanisamy Hussein, Mohd Zobir Fakurazi, Sharida Twyman, Lance J. Graphene oxide-gallic acid nanodelivery system for cancer therapy |
| title | Graphene oxide-gallic acid nanodelivery system for cancer therapy |
| title_full | Graphene oxide-gallic acid nanodelivery system for cancer therapy |
| title_fullStr | Graphene oxide-gallic acid nanodelivery system for cancer therapy |
| title_full_unstemmed | Graphene oxide-gallic acid nanodelivery system for cancer therapy |
| title_short | Graphene oxide-gallic acid nanodelivery system for cancer therapy |
| title_sort | graphene oxide-gallic acid nanodelivery system for cancer therapy |
| topic | Drug delivery systems; Graphene oxide; Gallic acid; Controlled-release; Cytotoxicity |
| url | http://psasir.upm.edu.my/id/eprint/54398/ http://psasir.upm.edu.my/id/eprint/54398/ http://psasir.upm.edu.my/id/eprint/54398/ http://psasir.upm.edu.my/id/eprint/54398/1/Graphene%20oxide-gallic%20acid%20nanodelivery%20system%20for%20cancer%20therapy.pdf |