Expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes
Endothelial dysfunction appears to be an early sign indicating vascular damage and predicts the progression of atherosclerosis and cardiovascular disorders. Extensive clinical and experimental evidence suggests that endothelial dysfunction occurs in Type 2 Diabetes Mellitus (T2DM) and prediabetes pa...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/54249/ http://psasir.upm.edu.my/id/eprint/54249/1/Expression%20profiling%20of%20genes%20related%20to%20endothelial%20cells%20biology.pdf |
| _version_ | 1848852493393461248 |
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| author | Moradipoor, Sara Ismail, Patimah Etemad, Ali Wan Sulaiman, Wan Aliaa Ahmadloo, Salma |
| author_facet | Moradipoor, Sara Ismail, Patimah Etemad, Ali Wan Sulaiman, Wan Aliaa Ahmadloo, Salma |
| author_sort | Moradipoor, Sara |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Endothelial dysfunction appears to be an early sign indicating vascular damage and predicts the progression of atherosclerosis and cardiovascular disorders. Extensive clinical and experimental evidence suggests that endothelial dysfunction occurs in Type 2 Diabetes Mellitus (T2DM) and prediabetes patients. This study was carried out with an aim to appraise the expression levels in the peripheral blood of 84 genes related to endothelial cells biology in patients with diagnosed T2DM or prediabetes, trying to identify new genes whose expression might be changed under these pathological conditions. The study covered a total of 45 participants. The participants were divided into three groups: group 1, patients with T2DM; group 2, patients with prediabetes; group 3, control group. The gene expression analysis was performed using the Endothelial Cell Biology RT2 Profiler PCR Array. In the case of T2DM, 59 genes were found to be upregulated, and four genes were observed to be downregulated. In prediabetes patients, increased expression was observed for 49 genes, with two downregulated genes observed. Our results indicate that diabetic and prediabetic conditions change the expression levels of genes related to endothelial cells biology and, consequently, may increase the risk for occurrence of endothelial dysfunction. |
| first_indexed | 2025-11-15T10:38:57Z |
| format | Article |
| id | upm-54249 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:38:57Z |
| publishDate | 2016 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-542492018-03-08T07:39:37Z http://psasir.upm.edu.my/id/eprint/54249/ Expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes Moradipoor, Sara Ismail, Patimah Etemad, Ali Wan Sulaiman, Wan Aliaa Ahmadloo, Salma Endothelial dysfunction appears to be an early sign indicating vascular damage and predicts the progression of atherosclerosis and cardiovascular disorders. Extensive clinical and experimental evidence suggests that endothelial dysfunction occurs in Type 2 Diabetes Mellitus (T2DM) and prediabetes patients. This study was carried out with an aim to appraise the expression levels in the peripheral blood of 84 genes related to endothelial cells biology in patients with diagnosed T2DM or prediabetes, trying to identify new genes whose expression might be changed under these pathological conditions. The study covered a total of 45 participants. The participants were divided into three groups: group 1, patients with T2DM; group 2, patients with prediabetes; group 3, control group. The gene expression analysis was performed using the Endothelial Cell Biology RT2 Profiler PCR Array. In the case of T2DM, 59 genes were found to be upregulated, and four genes were observed to be downregulated. In prediabetes patients, increased expression was observed for 49 genes, with two downregulated genes observed. Our results indicate that diabetic and prediabetic conditions change the expression levels of genes related to endothelial cells biology and, consequently, may increase the risk for occurrence of endothelial dysfunction. Hindawi Publishing Corporation 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/54249/1/Expression%20profiling%20of%20genes%20related%20to%20endothelial%20cells%20biology.pdf Moradipoor, Sara and Ismail, Patimah and Etemad, Ali and Wan Sulaiman, Wan Aliaa and Ahmadloo, Salma (2016) Expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes. BioMed Research International, 2016. art. no. 1845638. pp. 1-12. ISSN 2314-6133; ESSN: 2314-6141 https://www.hindawi.com/journals/bmri/2016/1845638/abs/ Profiling of genes; Endothelial cells biology; Type 2 diabetes; Pre-diabetes 10.1155/2016/1845638 |
| spellingShingle | Profiling of genes; Endothelial cells biology; Type 2 diabetes; Pre-diabetes Moradipoor, Sara Ismail, Patimah Etemad, Ali Wan Sulaiman, Wan Aliaa Ahmadloo, Salma Expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes |
| title | Expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes |
| title_full | Expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes |
| title_fullStr | Expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes |
| title_full_unstemmed | Expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes |
| title_short | Expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes |
| title_sort | expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes |
| topic | Profiling of genes; Endothelial cells biology; Type 2 diabetes; Pre-diabetes |
| url | http://psasir.upm.edu.my/id/eprint/54249/ http://psasir.upm.edu.my/id/eprint/54249/ http://psasir.upm.edu.my/id/eprint/54249/ http://psasir.upm.edu.my/id/eprint/54249/1/Expression%20profiling%20of%20genes%20related%20to%20endothelial%20cells%20biology.pdf |