Evaluation of endothelial cell adhesion molecules and anti-C1q antibody in discriminating between active and non-active systemic lupus erythematosus
Background: Detecting the active state of systemic lupus erythematosus (SLE) is important but challenging. This study aimed to determine the diagnostic accuracy of serum endothelial cell adhesion molecules (ICAM-1 and VCAM-1) and anti-C1q antibody in discriminating between active and non-active SLE....
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Sains Malaysia
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/54211/ http://psasir.upm.edu.my/id/eprint/54211/1/Evaluation%20of%20endothelial%20cell%20adhesion%20molecules%20.pdf |
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| author | Mahayidin, Hasni Yahya, Nurul Khaiza Wan Ghazali, Wan Syamimee Mohd Ismail, Asmahan Wan Ab Hamid, Wan Zuraida |
| author_facet | Mahayidin, Hasni Yahya, Nurul Khaiza Wan Ghazali, Wan Syamimee Mohd Ismail, Asmahan Wan Ab Hamid, Wan Zuraida |
| author_sort | Mahayidin, Hasni |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Detecting the active state of systemic lupus erythematosus (SLE) is important but challenging. This study aimed to determine the diagnostic accuracy of serum endothelial cell adhesion molecules (ICAM-1 and VCAM-1) and anti-C1q antibody in discriminating between active and non-active SLE. Methods: Using SELENA-SLE disease activity index (SLEDAI), 95 SLE patients (45 active and 50 non-active) were assessed. A score above five was considered indicative of active SLE. The blood samples were tested for serum ICAM-1, VCAM-1 and anti-C1q antibody using enzyme-linked immunosorbent assay (ELISA). Results: The levels of serum VCAM-1 and anti-C1q antibody were significantly higher in active SLE patients. Both VCAM-1 and anti-C1q were able to discriminate between active and non-active SLE (p-value < 0.001 and 0.005, respectively). From the receiver operating characteristic curves (ROCs) constructed, the optimal cut-off values for VCAM-1 and anti-C1q antibody in discriminating between active and non-active SLE were 30.5 ng/mL (69.0% sensitivity, 60.0% specificity, PPV 58.5%, NPV 66.7%) and 7.86 U/mL (75.6% sensitivity, 80% specificity, PPV 77.3%, NPV 78.4%), respectively. However, serum ICAM-1 level was unable to discriminate between the two groups (p-value = 0.193). Conclusion: Anti-C1q antibody demonstrated the best diagnostic accuracy in discriminating between active and non-active SLE patients. |
| first_indexed | 2025-11-15T10:38:47Z |
| format | Article |
| id | upm-54211 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:38:47Z |
| publishDate | 2016 |
| publisher | Penerbit Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-542112018-03-06T08:19:01Z http://psasir.upm.edu.my/id/eprint/54211/ Evaluation of endothelial cell adhesion molecules and anti-C1q antibody in discriminating between active and non-active systemic lupus erythematosus Mahayidin, Hasni Yahya, Nurul Khaiza Wan Ghazali, Wan Syamimee Mohd Ismail, Asmahan Wan Ab Hamid, Wan Zuraida Background: Detecting the active state of systemic lupus erythematosus (SLE) is important but challenging. This study aimed to determine the diagnostic accuracy of serum endothelial cell adhesion molecules (ICAM-1 and VCAM-1) and anti-C1q antibody in discriminating between active and non-active SLE. Methods: Using SELENA-SLE disease activity index (SLEDAI), 95 SLE patients (45 active and 50 non-active) were assessed. A score above five was considered indicative of active SLE. The blood samples were tested for serum ICAM-1, VCAM-1 and anti-C1q antibody using enzyme-linked immunosorbent assay (ELISA). Results: The levels of serum VCAM-1 and anti-C1q antibody were significantly higher in active SLE patients. Both VCAM-1 and anti-C1q were able to discriminate between active and non-active SLE (p-value < 0.001 and 0.005, respectively). From the receiver operating characteristic curves (ROCs) constructed, the optimal cut-off values for VCAM-1 and anti-C1q antibody in discriminating between active and non-active SLE were 30.5 ng/mL (69.0% sensitivity, 60.0% specificity, PPV 58.5%, NPV 66.7%) and 7.86 U/mL (75.6% sensitivity, 80% specificity, PPV 77.3%, NPV 78.4%), respectively. However, serum ICAM-1 level was unable to discriminate between the two groups (p-value = 0.193). Conclusion: Anti-C1q antibody demonstrated the best diagnostic accuracy in discriminating between active and non-active SLE patients. Penerbit Universiti Sains Malaysia 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/54211/1/Evaluation%20of%20endothelial%20cell%20adhesion%20molecules%20.pdf Mahayidin, Hasni and Yahya, Nurul Khaiza and Wan Ghazali, Wan Syamimee and Mohd Ismail, Asmahan and Wan Ab Hamid, Wan Zuraida (2016) Evaluation of endothelial cell adhesion molecules and anti-C1q antibody in discriminating between active and non-active systemic lupus erythematosus. Malaysian Journal of Medical Sciences, 23 (3). pp. 22-31. ISSN 1394-195X; ESSN: 2180-4303 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934715/ Cell adhesion molecules; Intercellular adhesion molecule-1 (ICAM-1); Vascular cell adhesion molecule-1 (VCAM-1); Anti-C1q antibody; Systemic lupus erythematosus |
| spellingShingle | Cell adhesion molecules; Intercellular adhesion molecule-1 (ICAM-1); Vascular cell adhesion molecule-1 (VCAM-1); Anti-C1q antibody; Systemic lupus erythematosus Mahayidin, Hasni Yahya, Nurul Khaiza Wan Ghazali, Wan Syamimee Mohd Ismail, Asmahan Wan Ab Hamid, Wan Zuraida Evaluation of endothelial cell adhesion molecules and anti-C1q antibody in discriminating between active and non-active systemic lupus erythematosus |
| title | Evaluation of endothelial cell adhesion molecules and anti-C1q antibody in discriminating between active and non-active systemic lupus erythematosus |
| title_full | Evaluation of endothelial cell adhesion molecules and anti-C1q antibody in discriminating between active and non-active systemic lupus erythematosus |
| title_fullStr | Evaluation of endothelial cell adhesion molecules and anti-C1q antibody in discriminating between active and non-active systemic lupus erythematosus |
| title_full_unstemmed | Evaluation of endothelial cell adhesion molecules and anti-C1q antibody in discriminating between active and non-active systemic lupus erythematosus |
| title_short | Evaluation of endothelial cell adhesion molecules and anti-C1q antibody in discriminating between active and non-active systemic lupus erythematosus |
| title_sort | evaluation of endothelial cell adhesion molecules and anti-c1q antibody in discriminating between active and non-active systemic lupus erythematosus |
| topic | Cell adhesion molecules; Intercellular adhesion molecule-1 (ICAM-1); Vascular cell adhesion molecule-1 (VCAM-1); Anti-C1q antibody; Systemic lupus erythematosus |
| url | http://psasir.upm.edu.my/id/eprint/54211/ http://psasir.upm.edu.my/id/eprint/54211/ http://psasir.upm.edu.my/id/eprint/54211/1/Evaluation%20of%20endothelial%20cell%20adhesion%20molecules%20.pdf |