Stem cells therapy for treatment of ocular disorders
Sustenance of visual function is the ultimate focus of ophthalmologists. Failure of complete recovery of visual function and complications that follow conventional treatments have shifted search to a new form of therapy using stem cells. Stem cell progenitors play a major role in replenishing degene...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/53893/ http://psasir.upm.edu.my/id/eprint/53893/1/Stem%20cells%20therapy%20for%20treatment%20of%20ocular%20disorders.pdf |
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| author | Sivan, Padma Priya Syed, Sakinah Mok, Pooi Ling Higuchi, Akon Murugan, Kadarkarai A. Alarfaj, Abdullah Munusamy, Murugan A. Hamat, Rukman Awang Umezawa, Akihiro Kumar, Suresh |
| author_facet | Sivan, Padma Priya Syed, Sakinah Mok, Pooi Ling Higuchi, Akon Murugan, Kadarkarai A. Alarfaj, Abdullah Munusamy, Murugan A. Hamat, Rukman Awang Umezawa, Akihiro Kumar, Suresh |
| author_sort | Sivan, Padma Priya |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Sustenance of visual function is the ultimate focus of ophthalmologists. Failure of complete recovery of visual function and complications that follow conventional treatments have shifted search to a new form of therapy using stem cells. Stem cell progenitors play a major role in replenishing degenerated cells despite being present in low quantity and quiescence in our body. Unlike other tissues and cells, regeneration of new optic cells responsible for visual function is rarely observed. Understanding the transcription factors and genes responsible for optic cells development will assist scientists in formulating a strategy to activate and direct stem cells renewal and differentiation. We review the processes of human eye development and address the strategies that have been exploited in an effort to regain visual function in the preclinical and clinical state. The update of clinical findings of patients receiving stem cell treatment is also presented. |
| first_indexed | 2025-11-15T10:37:32Z |
| format | Article |
| id | upm-53893 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:37:32Z |
| publishDate | 2016 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-538932018-02-20T08:52:03Z http://psasir.upm.edu.my/id/eprint/53893/ Stem cells therapy for treatment of ocular disorders Sivan, Padma Priya Syed, Sakinah Mok, Pooi Ling Higuchi, Akon Murugan, Kadarkarai A. Alarfaj, Abdullah Munusamy, Murugan A. Hamat, Rukman Awang Umezawa, Akihiro Kumar, Suresh Sustenance of visual function is the ultimate focus of ophthalmologists. Failure of complete recovery of visual function and complications that follow conventional treatments have shifted search to a new form of therapy using stem cells. Stem cell progenitors play a major role in replenishing degenerated cells despite being present in low quantity and quiescence in our body. Unlike other tissues and cells, regeneration of new optic cells responsible for visual function is rarely observed. Understanding the transcription factors and genes responsible for optic cells development will assist scientists in formulating a strategy to activate and direct stem cells renewal and differentiation. We review the processes of human eye development and address the strategies that have been exploited in an effort to regain visual function in the preclinical and clinical state. The update of clinical findings of patients receiving stem cell treatment is also presented. Hindawi Publishing Corporation 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/53893/1/Stem%20cells%20therapy%20for%20treatment%20of%20ocular%20disorders.pdf Sivan, Padma Priya and Syed, Sakinah and Mok, Pooi Ling and Higuchi, Akon and Murugan, Kadarkarai and A. Alarfaj, Abdullah and Munusamy, Murugan A. and Hamat, Rukman Awang and Umezawa, Akihiro and Kumar, Suresh (2016) Stem cells therapy for treatment of ocular disorders. Stem Cells International, 2016. art. no. 8304879. pp. 1-18. ISSN 1687-966X; ESSN: 1687-9678 https://www.hindawi.com/journals/sci/2016/8304879/abs/ Stem cells therapy; Ocular disorders 10.1155/2016/8304879 |
| spellingShingle | Stem cells therapy; Ocular disorders Sivan, Padma Priya Syed, Sakinah Mok, Pooi Ling Higuchi, Akon Murugan, Kadarkarai A. Alarfaj, Abdullah Munusamy, Murugan A. Hamat, Rukman Awang Umezawa, Akihiro Kumar, Suresh Stem cells therapy for treatment of ocular disorders |
| title | Stem cells therapy for treatment of ocular disorders |
| title_full | Stem cells therapy for treatment of ocular disorders |
| title_fullStr | Stem cells therapy for treatment of ocular disorders |
| title_full_unstemmed | Stem cells therapy for treatment of ocular disorders |
| title_short | Stem cells therapy for treatment of ocular disorders |
| title_sort | stem cells therapy for treatment of ocular disorders |
| topic | Stem cells therapy; Ocular disorders |
| url | http://psasir.upm.edu.my/id/eprint/53893/ http://psasir.upm.edu.my/id/eprint/53893/ http://psasir.upm.edu.my/id/eprint/53893/ http://psasir.upm.edu.my/id/eprint/53893/1/Stem%20cells%20therapy%20for%20treatment%20of%20ocular%20disorders.pdf |