Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis
Cytochrome P450s constitute the largest family of enzymatic proteins in plants acting on various endogenous and xenobiotic molecules. They are monooxygenases that insert one oxygen atom into inert hydrophobic molecules to make them more reactive and hydro-soluble. Besides for physiological functions...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer Verlag
2016
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/53598/ http://psasir.upm.edu.my/id/eprint/53598/1/Plant%20cytochrome%20P450s.pdf |
| _version_ | 1848852325468209152 |
|---|---|
| author | Rasool, Saiema Mohamed, Rozi |
| author_facet | Rasool, Saiema Mohamed, Rozi |
| author_sort | Rasool, Saiema |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Cytochrome P450s constitute the largest family of enzymatic proteins in plants acting on various endogenous and xenobiotic molecules. They are monooxygenases that insert one oxygen atom into inert hydrophobic molecules to make them more reactive and hydro-soluble. Besides for physiological functions, the extremely versatile cytochrome P450 biocatalysts are highly demanded in the fields of biotechnology, medicine, and phytoremediation. The nature of reactions catalyzed by P450s is irreversible, which makes these enzymes attractions in the evolution of plant metabolic pathways. P450s are prime targets in metabolic engineering approaches for improving plant defense against insects and pathogens and for production of secondary metabolites such as the anti-neoplastic drugs taxol or indole alkaloids. The emerging examples of P450 involvement in natural product synthesis in traditional medicinal plant species are becoming increasingly interesting, as they provide new alternatives to modern medicines. In view of the divergent roles of P450s, we review their classification and nomenclature, functions and evolution, role in biosynthesis of secondary metabolites, and use as tools in pharmacology. |
| first_indexed | 2025-11-15T10:36:17Z |
| format | Article |
| id | upm-53598 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:36:17Z |
| publishDate | 2016 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-535982017-11-14T05:19:31Z http://psasir.upm.edu.my/id/eprint/53598/ Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis Rasool, Saiema Mohamed, Rozi Cytochrome P450s constitute the largest family of enzymatic proteins in plants acting on various endogenous and xenobiotic molecules. They are monooxygenases that insert one oxygen atom into inert hydrophobic molecules to make them more reactive and hydro-soluble. Besides for physiological functions, the extremely versatile cytochrome P450 biocatalysts are highly demanded in the fields of biotechnology, medicine, and phytoremediation. The nature of reactions catalyzed by P450s is irreversible, which makes these enzymes attractions in the evolution of plant metabolic pathways. P450s are prime targets in metabolic engineering approaches for improving plant defense against insects and pathogens and for production of secondary metabolites such as the anti-neoplastic drugs taxol or indole alkaloids. The emerging examples of P450 involvement in natural product synthesis in traditional medicinal plant species are becoming increasingly interesting, as they provide new alternatives to modern medicines. In view of the divergent roles of P450s, we review their classification and nomenclature, functions and evolution, role in biosynthesis of secondary metabolites, and use as tools in pharmacology. Springer Verlag 2016-09 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/53598/1/Plant%20cytochrome%20P450s.pdf Rasool, Saiema and Mohamed, Rozi (2016) Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis. Protoplasma, 253 (5). pp. 1197-1209. ISSN 0033-183X; ESSN: 1615-6102 https://link.springer.com/article/10.1007%2Fs00709-015-0884-4 10.1007/s00709-015-0884-4 |
| spellingShingle | Rasool, Saiema Mohamed, Rozi Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis |
| title | Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis |
| title_full | Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis |
| title_fullStr | Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis |
| title_full_unstemmed | Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis |
| title_short | Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis |
| title_sort | plant cytochrome p450s: nomenclature and involvement in natural product biosynthesis |
| url | http://psasir.upm.edu.my/id/eprint/53598/ http://psasir.upm.edu.my/id/eprint/53598/ http://psasir.upm.edu.my/id/eprint/53598/ http://psasir.upm.edu.my/id/eprint/53598/1/Plant%20cytochrome%20P450s.pdf |