Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets

This research was conducted aiming to assess the flow and physicochemical properties of fruit powder and their relationship with the dissolution of tablets containing effervescent agents. Commercial pitaya, pineapple, mango and guava fruit powders were used as samples in this research. Fruit powder...

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Main Authors: Saifullah, M., Yusof, Yus Aniza, Chin, Nyuk Ling, Aziz, M. G.
Format: Article
Language:English
Published: Elsevier 2016
Online Access:http://psasir.upm.edu.my/id/eprint/53575/
http://psasir.upm.edu.my/id/eprint/53575/1/Physicochemical%20and%20flow%20properties%20of%20fruit%20powder%20and%20their%20effect%20on%20the%20dissolution%20of%20fast%20dissolving%20fruit%20powder%20tablets.pdf
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author Saifullah, M.
Yusof, Yus Aniza
Chin, Nyuk Ling
Aziz, M. G.
author_facet Saifullah, M.
Yusof, Yus Aniza
Chin, Nyuk Ling
Aziz, M. G.
author_sort Saifullah, M.
building UPM Institutional Repository
collection Online Access
description This research was conducted aiming to assess the flow and physicochemical properties of fruit powder and their relationship with the dissolution of tablets containing effervescent agents. Commercial pitaya, pineapple, mango and guava fruit powders were used as samples in this research. Fruit powder tablets were prepared by using direct compaction method. Powder properties of individual fruits as well as their tablet formulation (fruit powder + effervescent agent + artificial sweeteners) analysed using standard methods were found significantly different at P < 0.001. The flowability and cohesiveness as determined by Carr index and Hausner ratio of individual fruit powders and their formulation were also different but in the range of passable class. The relationship of total dissolution time with moisture, protein, fat content and porosity of fruit powder tablets was polynomial as determined by multiple regression analysis. Dissolution rate of effervescent fruit powder tablets was much higher compared to normal fruit powder tablets in both dissolution medium (water and simulated saliva fluid). Among the fruit powder tablets, pitaya powder tablet went for fast dissolution (6 min) in simulated saliva fluid whereas guava powder tablets took the longest time (90 min) for complete dissolution in water. Based on this study, a better understanding of the physicochemical properties of fruit powder and their relationship with the dissolution rate and the effect of effervescent agents on the dissolution rate has been obtained, which is essential for processing and handling of fruit powder and tablet preparation as well as for the improvement of the dissolution rate.
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institution Universiti Putra Malaysia
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spelling upm-535752017-11-08T04:47:08Z http://psasir.upm.edu.my/id/eprint/53575/ Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets Saifullah, M. Yusof, Yus Aniza Chin, Nyuk Ling Aziz, M. G. This research was conducted aiming to assess the flow and physicochemical properties of fruit powder and their relationship with the dissolution of tablets containing effervescent agents. Commercial pitaya, pineapple, mango and guava fruit powders were used as samples in this research. Fruit powder tablets were prepared by using direct compaction method. Powder properties of individual fruits as well as their tablet formulation (fruit powder + effervescent agent + artificial sweeteners) analysed using standard methods were found significantly different at P < 0.001. The flowability and cohesiveness as determined by Carr index and Hausner ratio of individual fruit powders and their formulation were also different but in the range of passable class. The relationship of total dissolution time with moisture, protein, fat content and porosity of fruit powder tablets was polynomial as determined by multiple regression analysis. Dissolution rate of effervescent fruit powder tablets was much higher compared to normal fruit powder tablets in both dissolution medium (water and simulated saliva fluid). Among the fruit powder tablets, pitaya powder tablet went for fast dissolution (6 min) in simulated saliva fluid whereas guava powder tablets took the longest time (90 min) for complete dissolution in water. Based on this study, a better understanding of the physicochemical properties of fruit powder and their relationship with the dissolution rate and the effect of effervescent agents on the dissolution rate has been obtained, which is essential for processing and handling of fruit powder and tablet preparation as well as for the improvement of the dissolution rate. Elsevier 2016-11 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/53575/1/Physicochemical%20and%20flow%20properties%20of%20fruit%20powder%20and%20their%20effect%20on%20the%20dissolution%20of%20fast%20dissolving%20fruit%20powder%20tablets.pdf Saifullah, M. and Yusof, Yus Aniza and Chin, Nyuk Ling and Aziz, M. G. (2016) Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets. Powder Technology, 301. pp. 396-404. ISSN 0032-5910; ESSN: 1873-328X http://www.sciencedirect.com/science/article/pii/S0032591016303746 10.1016/j.powtec.2016.06.035
spellingShingle Saifullah, M.
Yusof, Yus Aniza
Chin, Nyuk Ling
Aziz, M. G.
Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets
title Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets
title_full Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets
title_fullStr Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets
title_full_unstemmed Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets
title_short Physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets
title_sort physicochemical and flow properties of fruit powder and their effect on the dissolution of fast dissolving fruit powder tablets
url http://psasir.upm.edu.my/id/eprint/53575/
http://psasir.upm.edu.my/id/eprint/53575/
http://psasir.upm.edu.my/id/eprint/53575/
http://psasir.upm.edu.my/id/eprint/53575/1/Physicochemical%20and%20flow%20properties%20of%20fruit%20powder%20and%20their%20effect%20on%20the%20dissolution%20of%20fast%20dissolving%20fruit%20powder%20tablets.pdf