Nanoemulsified gamma-oryzanol rich fraction blend regulates hepatic cholesterol metabolism and cardiovascular disease risk in hypercholesterolaemic rats
We have reported that a bioactive-rich fraction, called EORY, from a combination of supercritical fluid-extracted rice bran oil and palm oil has abundant gamma-oryzanol, tocopherols and tocotrienol. Moreover, EORY has balanced composition of polyunsaturated:saturated fatty acids, with the potential...
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| Format: | Article |
| Language: | English |
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Elsevier BV
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/53359/ http://psasir.upm.edu.my/id/eprint/53359/1/Nanoemulsified%20gamma-oryzanol%20rich%20fraction%20blend%20regulates%20hepatic%20cholesterol%20metabolism%20and%20cardiovascular%20disease%20risk%20in%20hypercholesterolaemic%20rats.pdf |
| _version_ | 1848852261680185344 |
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| author | Ishaka, Aminu Imam, Mustapha Umar Ismail, Maznah Mahmud, Rozi Zakaria Abu Bakar, Zuki |
| author_facet | Ishaka, Aminu Imam, Mustapha Umar Ismail, Maznah Mahmud, Rozi Zakaria Abu Bakar, Zuki |
| author_sort | Ishaka, Aminu |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | We have reported that a bioactive-rich fraction, called EORY, from a combination of supercritical fluid-extracted rice bran oil and palm oil has abundant gamma-oryzanol, tocopherols and tocotrienol. Moreover, EORY has balanced composition of polyunsaturated:saturated fatty acids, with the potential for hypocholesterolaemic and antioxidant effects. However, the bioactive compounds in EORY are lipophilic and therefore pose bioavailability problems. This study evaluated the cardioprotective effects of orally-administered EORY emulsion and its nanoemulsion (NEORY) on diet-induced hypercholesterolaemic rats. NEORY reduced body weight gain, heart weight, lipid parameters and oxidised LDL, and improved HDL better than EORY and simvastatin. NEORY also significantly increased hepatic mRNA expression of HMGCoA reductase, apolipoprotein A1 and LDLR, and lowered apolipoprotein B and LPL. The effects of NEORY on lipid parameters, lipid peroxidation markers and hepatic cholesterol metabolism suggested that it could regulate the risk of cardiovascular disease, possibly due to increased absorption of gamma-oryzanol, tocopherols and tocotrienol. |
| first_indexed | 2025-11-15T10:35:16Z |
| format | Article |
| id | upm-53359 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:35:16Z |
| publishDate | 2016 |
| publisher | Elsevier BV |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-533592017-10-24T02:22:54Z http://psasir.upm.edu.my/id/eprint/53359/ Nanoemulsified gamma-oryzanol rich fraction blend regulates hepatic cholesterol metabolism and cardiovascular disease risk in hypercholesterolaemic rats Ishaka, Aminu Imam, Mustapha Umar Ismail, Maznah Mahmud, Rozi Zakaria Abu Bakar, Zuki We have reported that a bioactive-rich fraction, called EORY, from a combination of supercritical fluid-extracted rice bran oil and palm oil has abundant gamma-oryzanol, tocopherols and tocotrienol. Moreover, EORY has balanced composition of polyunsaturated:saturated fatty acids, with the potential for hypocholesterolaemic and antioxidant effects. However, the bioactive compounds in EORY are lipophilic and therefore pose bioavailability problems. This study evaluated the cardioprotective effects of orally-administered EORY emulsion and its nanoemulsion (NEORY) on diet-induced hypercholesterolaemic rats. NEORY reduced body weight gain, heart weight, lipid parameters and oxidised LDL, and improved HDL better than EORY and simvastatin. NEORY also significantly increased hepatic mRNA expression of HMGCoA reductase, apolipoprotein A1 and LDLR, and lowered apolipoprotein B and LPL. The effects of NEORY on lipid parameters, lipid peroxidation markers and hepatic cholesterol metabolism suggested that it could regulate the risk of cardiovascular disease, possibly due to increased absorption of gamma-oryzanol, tocopherols and tocotrienol. Elsevier BV 2016-10 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/53359/1/Nanoemulsified%20gamma-oryzanol%20rich%20fraction%20blend%20regulates%20hepatic%20cholesterol%20metabolism%20and%20cardiovascular%20disease%20risk%20in%20hypercholesterolaemic%20rats.pdf Ishaka, Aminu and Imam, Mustapha Umar and Ismail, Maznah and Mahmud, Rozi and Zakaria Abu Bakar, Zuki (2016) Nanoemulsified gamma-oryzanol rich fraction blend regulates hepatic cholesterol metabolism and cardiovascular disease risk in hypercholesterolaemic rats. Journal of Functional Foods, 26. pp. 338-349. ISSN 1756-4646; ESSN: 2214-9414 http://www.sciencedirect.com/science/article/pii/S1756464616302250 10.1016/j.jff.2016.08.015 |
| spellingShingle | Ishaka, Aminu Imam, Mustapha Umar Ismail, Maznah Mahmud, Rozi Zakaria Abu Bakar, Zuki Nanoemulsified gamma-oryzanol rich fraction blend regulates hepatic cholesterol metabolism and cardiovascular disease risk in hypercholesterolaemic rats |
| title | Nanoemulsified gamma-oryzanol rich fraction blend regulates hepatic cholesterol metabolism and cardiovascular disease risk in hypercholesterolaemic rats |
| title_full | Nanoemulsified gamma-oryzanol rich fraction blend regulates hepatic cholesterol metabolism and cardiovascular disease risk in hypercholesterolaemic rats |
| title_fullStr | Nanoemulsified gamma-oryzanol rich fraction blend regulates hepatic cholesterol metabolism and cardiovascular disease risk in hypercholesterolaemic rats |
| title_full_unstemmed | Nanoemulsified gamma-oryzanol rich fraction blend regulates hepatic cholesterol metabolism and cardiovascular disease risk in hypercholesterolaemic rats |
| title_short | Nanoemulsified gamma-oryzanol rich fraction blend regulates hepatic cholesterol metabolism and cardiovascular disease risk in hypercholesterolaemic rats |
| title_sort | nanoemulsified gamma-oryzanol rich fraction blend regulates hepatic cholesterol metabolism and cardiovascular disease risk in hypercholesterolaemic rats |
| url | http://psasir.upm.edu.my/id/eprint/53359/ http://psasir.upm.edu.my/id/eprint/53359/ http://psasir.upm.edu.my/id/eprint/53359/ http://psasir.upm.edu.my/id/eprint/53359/1/Nanoemulsified%20gamma-oryzanol%20rich%20fraction%20blend%20regulates%20hepatic%20cholesterol%20metabolism%20and%20cardiovascular%20disease%20risk%20in%20hypercholesterolaemic%20rats.pdf |