$Modulation of hydrogen peroxide-induced oxidative stress in human neuronal cells by Thymoquinone-rich fraction and Thymoquinone via transcriptomic regulation of antioxidant and apoptotic signaling genes$
QR Code

QR Code

Modulation of hydrogen peroxide-induced oxidative stress in human neuronal cells by Thymoquinone-rich fraction and Thymoquinone via transcriptomic regulation of antioxidant and apoptotic signaling genes

Nigella sativa Linn. (N. sativa) and its bioactive constituent Thymoquinone (TQ) have demonstrated numerous pharmacological attributes. In the present study, the neuroprotective properties of Thymoquinone-rich fraction (TQRF) and TQ against hydrogen peroxide- (H2O2-) induced neurotoxicity in differe...

Full description

Bibliographic Details
Main Authors:	Ismail, Norsharina, Ismail, Maznah, Azmi, Nur Hanisah, Abu Bakar, Muhammad Firdaus, Basri, Hamidon, Abdullah, Maizaton Atmadini
Format:	Article
Language:	English
Published:	Hindawi Publishing Corporation 2016
Online Access:	http://psasir.upm.edu.my/id/eprint/53316/ http://psasir.upm.edu.my/id/eprint/53316/1/Modulation%20of%20hydrogen%20peroxide-induced%20oxidative%20stress.pdf

Similar Items

Neuroprotective effects of thymoquinone-rich fraction and thymoquinone nanoemulsions in sporadic alzheimer’s disease rat model
by: Ismail, Norsharina
Published: (2019)

Thymoquinone rich fraction from Nigella sativa and thymoquinone are cytotoxic towards colon and leukemic carcinoma cell lines.
by: Ismail, Norsharina, et al.
Published: (2011)

Regulation of Apolipoprotein A-1 and Apolipoprotein B100 Genes by Thymoquinone Rich Fraction and Thymoquinone in HEPG2 Cells.
by: Al Naqeeb, Ghanya, et al.
Published: (2009)

Extraction of fixed oil and thymoquinone rich fractions (TQRF)
by: Ismail, Maznah, et al.
Published: (2014)

Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high fat/cholesterol diet-induced rats
by: Ismail, Norsharina, et al.
Published: (2017)

Thymoquinone prevents β-amyloid neurotoxicity in primary cultured cerebellar granule neurons
by: Ismail, Norsharina, et al.
Published: (2013)

Extraction, Gene Regulation and Hypocholesterolemic Effects, and Antioxidative Activity of Thymoquinone Rich Fraction and Thymoquinone from Nigella Sativa (pdf incomplete)
by: Al-Naqeeb, Ghanya Naji
Published: (2009)

Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats
by: Tubesha, Zaki, et al.
Published: (2013)

Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by thymoquinone-rich fraction and thymoquinone in HepG2 cells
by: Al-Naqeep, Ghanya, et al.
Published: (2009)

Effects of thymoquinone rich fraction and thymoquinone on plasma lipoprotein levels and hepatic low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase genes expression.
by: Al-Naqeep, Ghanya, et al.
Published: (2009)

Cytotoxic and apoptotic effects of curcumin and thymoquinone on HSC-2 cell line
by: Saleem, Khadeeja
Published: (2021)

Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats.
by: Ismail , Maznah, et al.
Published: (2010)

Development, characterization and anti-diabetic properties of thymoquinone rich fraction nanoemulsion obtained from black cumin
by: Tubesha, Zaki A.H.
Published: (2013)

Mechanistic basis for protection of differentiated SH-SY5Y cells by oryzanol-rich fraction against hydrogen peroxide-induced neurotoxicity
by: Ismail, Norsharina, et al.
Published: (2014)

Effect of thymoquinone and thymoquinone-loaded nanostructured lipid carrier in in vitro wound healing model
by: Alexander, Henna Roshini
Published: (2019)

Apoptotic activities of thymoquinone, an active ingredient of black seed (nigella sativa), in cervical cancer cell lines
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2014)

Ethyl acetate extract of germinated brown rice attenuates hydrogen peroxide-induced oxidative stress in human SH-SY5Y neuroblastoma cells: role of anti-apoptotic, pro-survival and antioxidant genes
by: Azmi, Nur Hanisah, et al.
Published: (2013)

Characterization and stability evaluation of thymoquinone nanoemulsions prepared by high-pressure homogenization
by: Tubesha, Zaki, et al.
Published: (2013)

Cytotoxicity of thymoquinone and thymoquinone-loaded nanostrustured lipid carrier on cervical cancer cells (SiHa and HeLa)
by: Ng, Wei Keat
Published: (2015)

Thymoquinone: Potential cure for inflammatory disorders and cancer
by: Woo, C., et al.
Published: (2012)

Thymoquinone and its pharmacological perspective: A review
by: Tabassum, Shabana, et al.
Published: (2021)

Migration and proliferation effects of Thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) and Thymoquinone (TQ) on in vitro wound healing models
by: Alexander, Henna Roshini, et al.
Published: (2019)

Effects of thymoquinone and thymoquinone-loaded nanostructured lipid carrier on hepatocellular carcinoma cell models, Hep3B and HepG2
by: Haron, Aminah Suhaila
Published: (2017)

Receptor mechanisms of Thymoquinone-induced hypotension in normotensive rats
by: Mizher, Hussam A., et al.
Published: (2014)

Thymoquinone content in marketed black seed oil in Malaysia
by: Alkhatib, Hamzeh, et al.
Published: (2020)

Hypotensive receptor mechanisms of Thymoquinone-treated ormotensive rats
by: Azzubaidi, Marwan Saad, et al.
Published: (2014)

Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
by: Mizher, Hussam A., et al.
Published: (2014)

Extraction of pharmacologically active thymoquinone in nigella sativa L.
by: Nazeri, Nasaruddin
Published: (2006)

Thymoquinone, an active ingredient of Black Seed (Nigela saliva) induces distinct apoptotic pathways in C33A and Siha Cervical Cancer Cell Lines)
by: Ichwan, Solachuddin JA, et al.
Published: (2012)

Antihypertensive and antihyperlipidemic activities of thymoquinone in l-name hypertensive rats
by: Azzubaidi, Marwan Saad, et al.
Published: (2015)

Effects of thymoquinone supplementation on cyclophosphamide toxicity of mouse embryo in vitro
by: Abdul Rahman, Suzanah, et al.
Published: (2014)

Acrylated vegetable oil nanoparticle as a carrier and controlled release of the anticancer drug-thymoquinone
by: Tajau, Rida, et al.

Cytotoxicity of Thymoquinone (TQ) from Nigella sativa towards human cervical carcinoma cells (HeLa).
by: Saiful Yazan, Latifah, et al.
Published: (2009)

y-tocotrienol protecs against hydrogen peroxide-induced replicative senescence by regulating apoptotic pathway and modulating telomerase activity
by: Norhazira AR,, et al.
Published: (2011)

Effects on mouse spermatogenesis and DNA fragmentation following exposure to cyclophosphamide and thymoquinone
by: Saheera, Kamarzaman, et al.
Published: (2013)

Synthesis and optimization of chitosan nanoparticles loaded with l-ascorbic acid and thymoquinone
by: Othman, Nurhanisah, et al.
Published: (2018)

Thymoquinone loaded nanostructured lipid carriers (TQ-NLC) and uses thereof
by: Saiful Yazan, Latifah, et al.
Published: (2012)

Lycopene-rich fractions derived from pink guava by-product and their potential activity towards hydrogen peroxide-induced cellular and DNA damage.
by: Kong , Kin Weng, et al.
Published: (2010)

Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein
by: Ng, Wei Keat, et al.
Published: (2011)

The chemopreventive effects of Nigella sativa extract and Thymoquinone in a paternal toxicity study
by: Abdul Samat, Nadia Hanis, et al.
Published: (2015)