Safety assessment of two new lactobacillus strains as probiotic for human using a rat model
Two previously isolated Lactobacillus strains (L. fermentum HM3 from human milk and L. buchneri FD2 from fermented dates), intended as probiotic for human, were assessed for their safety using acute and subacute oral toxicity tests in rats. In addition, their effects on cecal microflora and harmful...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/52920/ http://psasir.upm.edu.my/id/eprint/52920/1/Safety%20assessment%20of%20two%20new%20lactobacillus%20strains%20as%20probiotic%20for%20human%20using%20a%20rat%20model.pdf |
| _version_ | 1848852175527084032 |
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| author | Shokryazdan, Parisa Jahromi, Mohammad Faseleh Liang, Juan Boo Kalavathy, Ramasamy Sieo, Chin Chin Ho, Yin Wan |
| author_facet | Shokryazdan, Parisa Jahromi, Mohammad Faseleh Liang, Juan Boo Kalavathy, Ramasamy Sieo, Chin Chin Ho, Yin Wan |
| author_sort | Shokryazdan, Parisa |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Two previously isolated Lactobacillus strains (L. fermentum HM3 from human milk and L. buchneri FD2 from fermented dates), intended as probiotic for human, were assessed for their safety using acute and subacute oral toxicity tests in rats. In addition, their effects on cecal microflora and harmful bacterial enzymes (β-glucuronidase and β-glucosidase) of the tested animals were also determined. The results showed that L. buchneri FD2, L. fermentum HM3, or a mixture of them were safe up to a level of 1010 CFU/kg BW/day in a 14-day or 28-day treatment period. Both strains were well tolerated and there were no observed adverse effects on growth, feed consumption, cellular blood components and vital organs of the treated animals. The Lactobacillus strains were also able to reduce harmful intestinal bacterial enzymes, and decrease pathogenic bacterial populations while increasing beneficial bacterial populations. These results suggest that the two Lactobacillus strains are safe and could be potential probiotic for human. |
| first_indexed | 2025-11-15T10:33:54Z |
| format | Article |
| id | upm-52920 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:33:54Z |
| publishDate | 2016 |
| publisher | Public Library of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-529202022-03-18T04:28:07Z http://psasir.upm.edu.my/id/eprint/52920/ Safety assessment of two new lactobacillus strains as probiotic for human using a rat model Shokryazdan, Parisa Jahromi, Mohammad Faseleh Liang, Juan Boo Kalavathy, Ramasamy Sieo, Chin Chin Ho, Yin Wan Two previously isolated Lactobacillus strains (L. fermentum HM3 from human milk and L. buchneri FD2 from fermented dates), intended as probiotic for human, were assessed for their safety using acute and subacute oral toxicity tests in rats. In addition, their effects on cecal microflora and harmful bacterial enzymes (β-glucuronidase and β-glucosidase) of the tested animals were also determined. The results showed that L. buchneri FD2, L. fermentum HM3, or a mixture of them were safe up to a level of 1010 CFU/kg BW/day in a 14-day or 28-day treatment period. Both strains were well tolerated and there were no observed adverse effects on growth, feed consumption, cellular blood components and vital organs of the treated animals. The Lactobacillus strains were also able to reduce harmful intestinal bacterial enzymes, and decrease pathogenic bacterial populations while increasing beneficial bacterial populations. These results suggest that the two Lactobacillus strains are safe and could be potential probiotic for human. Public Library of Science 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/52920/1/Safety%20assessment%20of%20two%20new%20lactobacillus%20strains%20as%20probiotic%20for%20human%20using%20a%20rat%20model.pdf Shokryazdan, Parisa and Jahromi, Mohammad Faseleh and Liang, Juan Boo and Kalavathy, Ramasamy and Sieo, Chin Chin and Ho, Yin Wan (2016) Safety assessment of two new lactobacillus strains as probiotic for human using a rat model. PLoS one, 11 (7). pp. 1-17. ISSN 1932-6203 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965145/ 10.1371/journal.pone.0159851 |
| spellingShingle | Shokryazdan, Parisa Jahromi, Mohammad Faseleh Liang, Juan Boo Kalavathy, Ramasamy Sieo, Chin Chin Ho, Yin Wan Safety assessment of two new lactobacillus strains as probiotic for human using a rat model |
| title | Safety assessment of two new lactobacillus strains as probiotic for human using a rat model |
| title_full | Safety assessment of two new lactobacillus strains as probiotic for human using a rat model |
| title_fullStr | Safety assessment of two new lactobacillus strains as probiotic for human using a rat model |
| title_full_unstemmed | Safety assessment of two new lactobacillus strains as probiotic for human using a rat model |
| title_short | Safety assessment of two new lactobacillus strains as probiotic for human using a rat model |
| title_sort | safety assessment of two new lactobacillus strains as probiotic for human using a rat model |
| url | http://psasir.upm.edu.my/id/eprint/52920/ http://psasir.upm.edu.my/id/eprint/52920/ http://psasir.upm.edu.my/id/eprint/52920/ http://psasir.upm.edu.my/id/eprint/52920/1/Safety%20assessment%20of%20two%20new%20lactobacillus%20strains%20as%20probiotic%20for%20human%20using%20a%20rat%20model.pdf |