Role of microglia in embryonic neurogenesis
Microglia begin colonizing the developing brain as early as embryonic day 9, prior to the emergence of neurons and other glia. Their ontogeny is also distinct from other central nervous system cells, as they derive from yolk sac hematopoietic progenitors and not neural progenitors. In this review, w...
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| Format: | Article |
| Language: | English |
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Sage Publications
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/52912/ http://psasir.upm.edu.my/id/eprint/52912/1/Role%20of%20microglia%20in%20embryonic%20neurogenesis.pdf |
| _version_ | 1848852174443905024 |
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| author | Tong, Chih Kong Vidyadaran, Sharmili |
| author_facet | Tong, Chih Kong Vidyadaran, Sharmili |
| author_sort | Tong, Chih Kong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Microglia begin colonizing the developing brain as early as embryonic day 9, prior to the emergence of neurons and other glia. Their ontogeny is also distinct from other central nervous system cells, as they derive from yolk sac hematopoietic progenitors and not neural progenitors. In this review, we feature these unique characteristics of microglia and assess the spatiotemporal similarities between microglia colonization of the central nervous system and embryonic neurogenesis. We also infer to existing evidence for microglia function from embryonic through to postnatal neurodevelopment to postulate roles for microglia in neurogenesis. |
| first_indexed | 2025-11-15T10:33:53Z |
| format | Article |
| id | upm-52912 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T10:33:53Z |
| publishDate | 2016 |
| publisher | Sage Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-529122022-03-16T08:33:14Z http://psasir.upm.edu.my/id/eprint/52912/ Role of microglia in embryonic neurogenesis Tong, Chih Kong Vidyadaran, Sharmili Microglia begin colonizing the developing brain as early as embryonic day 9, prior to the emergence of neurons and other glia. Their ontogeny is also distinct from other central nervous system cells, as they derive from yolk sac hematopoietic progenitors and not neural progenitors. In this review, we feature these unique characteristics of microglia and assess the spatiotemporal similarities between microglia colonization of the central nervous system and embryonic neurogenesis. We also infer to existing evidence for microglia function from embryonic through to postnatal neurodevelopment to postulate roles for microglia in neurogenesis. Sage Publications 2016 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/52912/1/Role%20of%20microglia%20in%20embryonic%20neurogenesis.pdf Tong, Chih Kong and Vidyadaran, Sharmili (2016) Role of microglia in embryonic neurogenesis. Experimental Biology and Medicine, 241 (15). pp. 1669-1675. ISSN 1535-3702; ESSN: 1535-3699 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995495/ 10.1177/1535370216664430 |
| spellingShingle | Tong, Chih Kong Vidyadaran, Sharmili Role of microglia in embryonic neurogenesis |
| title | Role of microglia in embryonic neurogenesis |
| title_full | Role of microglia in embryonic neurogenesis |
| title_fullStr | Role of microglia in embryonic neurogenesis |
| title_full_unstemmed | Role of microglia in embryonic neurogenesis |
| title_short | Role of microglia in embryonic neurogenesis |
| title_sort | role of microglia in embryonic neurogenesis |
| url | http://psasir.upm.edu.my/id/eprint/52912/ http://psasir.upm.edu.my/id/eprint/52912/ http://psasir.upm.edu.my/id/eprint/52912/ http://psasir.upm.edu.my/id/eprint/52912/1/Role%20of%20microglia%20in%20embryonic%20neurogenesis.pdf |